Gut Microbiota in Human Immunodeficiency Virus Infection

Rudi Wisaksana (Division of Infectious and Tropical Disease, Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran/Hasan Sadikin General Hospital, Bandung)
Guntur Darmawan (Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran/Hasan Sadikin General Hospital, Bandung)
Nenny Agustanti (Division of Gastroentero-hepatology, Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran/Hasan Sadikin General Hospital, Bandung)
Dolvy Girawan (Division of Gastroentero-hepatology, Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran/Hasan Sadikin General Hospital, Bandung)

The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Vol 20, No 1 (2019): VOLUME 20, NUMBER 1, April 2019

Human microbiota, majority presents in human gastrointestinal tract, plays crucial role in body physiological functions, such as immune system. Human immunodeficiency virus (HIV) infection impairs gut barrier and alter the microbiota ecosystem, called dysbiosis. Different phase of HIV infection demonstrates different composition of gut microbiota. Antiretroviral treatment might improve the CD4 level, however, it inconsistently restore the gut ecosystem. Some studies in prebiotic and probiotic revealed the potential effect in reducing inflammation and restoring gut microbiota.