Jurnal Riset Kefarmasian Indonesia
Vol 5 No 1 (2023): Jurnal Riset Kefarmasian Indonesia

EVALUASI FISIK KRIM ANTIINFLAMASI EKSTRAK KULIT BAWANG MERAH DENGAN VARIASI KONSENTRASI TRIETANOLAMIN DAN ASAM STEARAT

April Nuraini (Stikes Ngudia Husada Madura)
Dianita Rahayu Puspitasari (Stikes Ngudia Husada Madura)
Ratri Rokhani (Stikes Ngudia Husada Madura)



Article Info

Publish Date
25 Jan 2023

Abstract

Inflammation is the body's defense function against the entry of organisms and other disturbances. The drugs used often have an effect on gastrointestinal disorders, so other alternative treatments are being developed that can minimize side effects. The quarcetin content of shallot skin extract, which has anti-inflammatory activity, is formulated in a cream dosage form. The emulsifiers in the m/a cream formula are stearic acid and triethanolamine (TEA). This study aims to determine the physical evaluation of an anti-inflammatory cream containing shallot skin extract with variations in concentrations of TEA and stearic acid. The method used in this study is the experimental method. Formulations I, II, and III with varying concentrations of TEA and stearic acid (2:8%, 3:10%, and 4:12%) were used. Tests carried out included organoleptic tests, homogeneity, pH, spreadability, and adhesion. The cream formula passed the organoleptic test with a distinctive shallot smell, semi-solid form, brownish red color, all formulas were homogeneous, pH 5.264-6.417, spreadability 3.849-6.251 cm, and adhesion 83-132 seconds. Higher concentrations of TEA and stearic acid had an effect on adhesion and spreadability but had no effect on organoleptic properties, homogeneity, or pH. Onion skin extract cream with a concentration of TEA:2%:8% stearic acid gave the best physical quality.

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Journal Info

Abbrev

jrki

Publisher

Subject

Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

Description

JURNAL RISET KEFARMASIAN INDONESIA adalah jurnal yang diterbitkan online dan diterbitkan dalam bentuk cetak. Jurnal ini diterbitkan 3 kali dalam 1 tahun (Januari, Mei dan September) Jurnal ini diterbitkan oleh APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia) Lingkup jurnal ini mencakup ...