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Jurnal Riset Kefarmasian Indonesia
Published by Asosiasi Pendidikan Diploma Farmasi Indonesia
ISSN : 2656131x     EISSN : 26558289     DOI : https://doi.org/10.33759/jrki
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health
JURNAL RISET KEFARMASIAN INDONESIA adalah jurnal yang diterbitkan online dan diterbitkan dalam bentuk cetak. Jurnal ini diterbitkan 3 kali dalam 1 tahun (Januari, Mei dan September) Jurnal ini diterbitkan oleh APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia) Lingkup jurnal ini mencakup Organisasi Farmasi, Kedokteran, Kimia Organik Sintetis, Kimia Organik Bahan Alami, Biokimia, Analisis Kimia, Kimia Fisik, Biologi, Mikrobiologi, Kultur Jaringan, Botani dan hewan yang terkait dengan produk farmasi, Keperawatan, Kebidanan, Analis Kesehatan, Nutrisi dan Kesehatan Masyarakat.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 215 Documents
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OPTIMASI KOMBINASI COCOA BUTTER DAN MILK BUTTER SEBAGAI BASIS BODY BUTTER EKSTRAK ETANOL DAUN JAMBU BIJI (Psidium guajava Linn) Suradnyana, I Gede Made; Mahardika, I Komang Gede; Siada, Nyoman Budiartha
Jurnal Riset Kefarmasian Indonesia Vol. 4 No. 2 (2022): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v4i2.242

Abstract

Guava leaf extract is known to contain flavonoids, a class of flavone compounds that have very strong antioxidant activity. The antioxidant activity of guava leaf ethanol extract as measured by the DPPH method showed an IC50 value of 72 µg/ml. Body butter preparations have a better ability to nourish and maintain skin moisture because they contain high oil components. Cocoa butter and milk butter are the bases that are widely used in body butter formulas and are able to maintain skin health. This study aims to determine the area of optimum composition of the combination of cocoa butter and milk butter in body butter preparations of guava leaf ethanol extract (Psidium guajava L.). This study used a factorial design with two factors, namely cocoa butter and milk butter and two levels, namely 2% and 4% for cocoa butter and 2% and 15% for milk butter. The observed responses were pH and spreadibility with data analysis using Design Expert and SPSS software. Based on the results of the research, the optimum area for the combination of cocoa butter and milk butter with the pH equation is Y = 6.00000 – 1.77504(X1) – 4.73345 (X2) + 1.8336(X1X2) and the dispersion equation is Y = 3 ,77692+0,366667(X1) – 0,005128(X2) + 0.033333(X1X2). The optimal composition area of cocoa butter and milk butter has been validated on the combination of 3% cocoa butter and 8,5% milk butter.
FORMULASI SEDIAAN SABUN CAIR EKSTRAK LIDAH BUAYA (Aloe vera L.) Mahayuni, Made Galih Dwi; Putra, I Gusti Ngurah Agung Windra Wartana; Wintariani, Ni Putu
Jurnal Riset Kefarmasian Indonesia Vol. 5 No. 1 (2023): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v5i1.309

Abstract

Skin is the external part of body which protects internal organs from external interference, such as bacteria, viruses, cold air, hot sun, exposure to UV radiation, pressure, etc. Maintain clean skin is an important thing to do to prevent skin diseases. The way to keep our skin clean is use a mild soap which is good for the skin. Soap is one of the preparations commonly used in daily life. The ingredients of liquid soap are made up of surfactants, thickeners, preservatives and pH regulators. The presence of surface-active agents in soap is important for cleansing the dirt from the skin. Thickeners are important in the soap to obtain the required viscosity of the formulation. The aim of this study was to determine the characteristics of aloe vera (Aloe Vera L.) liquid soap. This type of research is an experimental study with a completely randomized design. The formula will be tested for physical and chemical properties which include organoleptic tests, viscosity tests, specific gravity tests, foam stability tests, and pH tests. Aloe vera liquid soap in all formulas has physical and chemical characteristics that meet the standards where the viscosity values obtained are 2616-4188 cP, specific gravity 1.067-1.082, foam resistance 61-70%, and pH 6.1-7
PENGARUH VARIASI KONSENTRASI HPMC TERHADAP SIFAT FISIK GEL EKSTRAK KULIT PISANG AGUNG SEMERU (Musa paradisiaca L.) Eryani, Mikhania Christiningtyas; Siddiq, Hadi Barru Hakam Fajar; Rashati, Dewi; Safitri, Risma Khoiro
Jurnal Riset Kefarmasian Indonesia Vol. 5 No. 1 (2023): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v5i1.320

Abstract

The aims of this study was to determine the effect of HPMC variation concentration to the physical properties of Semeru Agung banana (Musa paradisiaca L.) skin extract gel. Gel was formulated with various HPMC concentration namely F1 (2%), F2 (3%) and F3 (4%). Gel was evaluated organoleptic, homogeinity, pH, viscosity, spreadbility and adhesion value. The results showed that F2 meet the organoleptic requirements while F1 and F3 did not meet. All formulas are homogeneous. The results of the pH test showed that the pH value of F1 was 5.9 ± 0; F2 of 5.8± 0 ; F3 of 5.9 ± 0. The results of the viscosity test showed that the viscosity value of F1 was 150 ± 0 dPas; F2 of 250 ± 0 dPas; F3 of 300 ± 0 dPas. The results of the dispersion test showed that the dispersion value of F1 was 5.6 ± 0.06 cm; F2 of 5.3 ± 0.29 cm ; F3 is 4.0 ± 0.12 cm. The results of the adhesion test showed that the value of the F1 adhesiveness was 11.04 ± 0.43 seconds; F2 of 17.4 ± 1.47 seconds; F3 is 24.2 ± 2.44 seconds. It is known that variations in HPMC concentration affect gel texture, viscosity, spreadability and adhesion, and have no effect on gel smell, color and pH.
ANALISIS DESKRIPTIF TERKAIT PENGETAHUAN PENGGUNAAN ANTIBIOTIK PADA WARGA RW 009 KELURAHAN DUREN SAWIT PERIODE MEI-JUNI 2022 Fidia, Fachdiana; Tuahuns, Farida; Niode, Harum Andini Putri
Jurnal Riset Kefarmasian Indonesia Vol. 5 No. 1 (2023): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v5i1.323

Abstract

Infectious diseases remain one of the world's public health concerns, particularly in developing countries. Excessive and inappropriate antibiotics use can lead to the emergence of bacterial resistance and increase the economic burden of health care; additionally. According to a preliminary survey conducted on residents of 009 Community Unit, Duren Sawit Sub-district aged 17-65 in January 2022, it demonstrated that 60% residents believed that antibiotics could treat fever and could be purchased without a prescription 40%. This research aimed to describe the knowledge of antibiotic use in the residents of 009 Community Unit, Duren Sawit Village. The study employed a descriptive quantitative type, where data collection was performed using a questionnaire. This research comprised 237 respondents, who were selected employing the proportional random sampling technique and required the inclusion criteria. The study’s findings indicated that out of 237 respondents, 99 individuals (42%) had good comprehension, 88 individuals (37%) had sufficient comprehension, and 50 individuals (21%) had inadequate comprehension. In summary, suppose described in each indicator, the level of public knowledge for the three indicators was as follows: 118 respondents (50%) have a good understanding of the meaning of antibiotics,104 respondents (44%) have a good understanding of the use of antibiotics, and 140 respondents (59%) had a good understanding of the undesirable effects of the use of antibiotics. The 4 most consumed antibiotics were Amoxicillin (55.7%), Fg Troches (14.3%), Cefixime (8.4%) and Azithromycin (8.4%). While the dose of taking antibiotics ranges from 1x to 4x a day, depends on the type of antibiotics.
HUBUNGAN LAMA KERJASAMA TERHADAP KEPERCAYAAN PELANGGAN PBF BINA PRIMA SEJATI Brahmono, Umul Angga; Saragi, Sahat; Andayani, Nurita
Jurnal Riset Kefarmasian Indonesia Vol. 5 No. 1 (2023): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v5i1.324

Abstract

The large number of pharmacies is not proportional to the number of PBF in DKI Jakarta, causing intense competition in drug distribution activities to pharmacies. The main concept of partnership or cooperation with customers is trust. Building trust will have an impact on bringing loyalty to continue working with the company. This study aims to determine the effect of the length of cooperation between PBF and pharmacies on customer trust. This research was conducted by survey and observation methods. The sampling technique was carried out by Probability Sampling with a Proportionate Stratified Random Sampling approach in order to obtain 69 pharmacies. The results showed that the length of cooperation from 69 pharmacies was 7-12 months for 1 pharmacy, 13-24 months for 8 pharmacies and >24 months for 60 pharmacies. The highest pharmacy confidence level is 85.51%, moderate is 13.04% and low is 1.45%. Based on the results of the Pearson correlation test, a sig value of >0.05 indicates that there is no relationship between length of cooperation and customer trust in PBF. This shows that there is no relationship between the length of time of cooperation with the level of trust the Pharmacy has in PBF Bina Prima Sejati.
UJI AKTIVITAS ANTIBAKTERI NANOPARTIKEL EKSTRAK ETANOL DAUN MATOA (Pometia pinnata J.R. Forst & G. Forst) TERHADAP BAKTERI Streptococcus mutans Fahira, Nelsa; Rahayu, Yayuk Putri; Nasution, Haris Munandar; Nasution, M Pandapotan
Jurnal Riset Kefarmasian Indonesia Vol. 5 No. 1 (2023): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v5i1.327

Abstract

Streptococcus mutans is one of the bacteria that plays an important role in the formation of dental caries. One of the plants known to have antibacterial compounds are matoa leaves (Pometia pinnata J.R. Forst & G. Forst) family Sapindaceae. The objective of this research was to determine the antibacterial activity of matoa leaves ethanolic extract nanoparticles is better than matoa leaves ethanolic extract against S. mutans bacteria. The research method was carried out experimentally. Free variables, namely the concentration of matoa leaf ethanol extract (KEDM 25% ; KEDM 50%; and KEDM 75%) and the concentration of nanoparticles of matoa leaf ethanol extract (KNDM 2.5%; KNDM 5%; and KNDM 7.5%). Bound variables are antibacterial activity of ethanol extract and nanoparticles of matoa leaf ethanol extract against S. mutans bacteria. The nanoparticle size of the extract was characterized using a Particle Size Analyzer (PSA). Test of antibacterial activity of ethanol extract and matoa leaf ethanol extract nanoparticles against S. mutans using the diffusion method to Kirby Bauer. The result of the extract nanoparticle size characterization was 324.97 nm. Zone of Inhibition (ZOI) values of antibacterial ethanol extract of matoa leaves against S. mutans were 12.00 mm (KEDM 25%), 12.50 mm (KEDM 50%), and 12.60 mm (KEDM 75%). The antibacterial ZOI values of matoa leaf ethanol extract nanoparticles against S. mutans were 8.00 mm (KNDM 2.5%), 9.06 mm (KNDM 5%), and 10.10 mm (KNDM 7.5%). The conclusion is that ethanol extract of matoa leaves can be used as extract nanoparticles, where the extract nanoparticle concentration of 7.5% already has the ability of antibacterial activity that is close to the concentration of 25% ethanol extract, so that it can be said that the extract nanoparticle preparation can reduce the dose of a drug even though it is in the resistant category compared to Amoxicillin 25 g with the susceptible category.
UJI AKTIVITAS ANTIBAKTERI NANOPARTIKEL EKSTRAK ETANOL DAUN MATOA (Pometia pinnata J.R. Forst & G. Forst) TERHADAP BAKTERI Escherichia coli Siregar, Huzeila Nisa; Rahayu, Yayuk Putri; Nasution, Haris Munandar; Nasution, M Pandapotan
Jurnal Riset Kefarmasian Indonesia Vol. 5 No. 1 (2023): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v5i1.329

Abstract

Escherichia coli was one of the bacteria that causes diarrhea. Matoa leaves (Pometia pinnata J.R. Forst & G. Forst) ) is a plant from the Sapindaceae family and is known to have antibacterial compounds. This study aims to make ethanol extract of matoa leaves into extract nanoparticles and to determine the antibacterial activity of ethanol extract nanoparticles better than ethanol extract of matoa leaves against E. coli bacteria. This research was conducted experimentally with free variables, namely the concentration of matoa leaf ethanol extract (KEDM 25%; KEDM 50%; and KEDM 75%), and the nanoparticle concentration of matoa leaf ethanol extract (KNDM 2.5%; KNDM 5%; and KNDM 7.5%). The bound variable was the antibacterial activity of ethanol extract and nanoparticles of ethanol extract of matoa leaves against E. coli bacteria. Nanoparticle manufacturing uses the ionic glassing method with chitosan 0.1% and Na-TPP 0.1% (1:1). The nanoparticle size characterization of the extract used a Particle Size Analyzer (PSA). Antibacterial activity test using the diffusion method of Kirby Bauer's agar. The result of the characterization of the extract nanoparticles obtained a size of 324.97 nm. The value of the antibacterial Zone Of Inhibition (ZOI) of matoa leaf ethanol extract was 13.9 mm (KEDM 25%); 14.6 mm (KEDM 50%); and 18 mm (KEDM 75%). The antibacterial ZOI value of the ethanol extract nanoparticles was 6.6 mm (KNDM 2.5%); 7.2 mm (KNDM 5%); and 7.7 mm (KNDM 7.5%). The conclusion of this research was that matoa leaf ethanol extract can be used as an extract nanoparticle, where with a concentration of 2.5% extract nanoparticles already has antibacterial activity capability which is equivalent to half the dose of 25% ethanol extract concentration of matoa leaves, so it can be said that the extract nanoparticle preparation can reduce the dose of a drug by up to half the dose, even though it is in the resistant category compared to Tetracycline 30 μg.
FORMULASI DAN UJI STABILITAS SEDIAAN TONER WAJAH EKSTRAK BUAH PARE (Momordica charantia L) SEBAGAI ANTI JERAWAT DENGAN VARIASI SURFAKTAN Noor, Muhammad; Malahayati, Siti; Nastiti, Kunti
Jurnal Riset Kefarmasian Indonesia Vol. 5 No. 1 (2023): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v5i1.330

Abstract

Bitter gourd extract (Momordica charantia L) contains secondary metabolites such as flavonoids, alkaloids, and saponins that can be antibacterial against acne-causing bacteria (Propionibacterium acnes). Momordica charantia L., could make into facial toner preparations to prevent the emergence and worsen acne. It is formulated with various concentrations of polysorbate 20 and performs stability testing. This study aimed at the optimal formula and analyzed the variations in the concentration effect of polysorbate 20 on the bitter gourd extract facial toner preparation. Bitter gourd extract would make into facial toner preparation with variations in the concentration of polysorbate 20. The accelerated stability test with the cycling test method includes before and after organoleptic, homogeneity, viscosity, and pH tests. The organoleptic stability result shows both stable formulas had the same liquid form, clear brown color, and characteristic rose odor. All formulations are stable on homogeneity, in which the particles are evenly mixed. The Formula I viscosity value is constantly stabilized and meets the parameters, while formula II is not but meets the parameters. The pH stability values of both formulas are stable and meet the parameters. Formula I is more optimal than formula II and the difference in surfactant concentration of polysorbate 20 has no effect on organoleptic, homogeneity, and pH but will affect viscosity.
EVALUASI FISIK KRIM ANTIINFLAMASI EKSTRAK KULIT BAWANG MERAH DENGAN VARIASI KONSENTRASI TRIETANOLAMIN DAN ASAM STEARAT Nuraini, April; Puspitasari, Dianita Rahayu; Rokhani, Ratri
Jurnal Riset Kefarmasian Indonesia Vol. 5 No. 1 (2023): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v5i1.338

Abstract

Inflammation is the body's defense function against the entry of organisms and other disturbances. The drugs used often have an effect on gastrointestinal disorders, so other alternative treatments are being developed that can minimize side effects. The quarcetin content of shallot skin extract, which has anti-inflammatory activity, is formulated in a cream dosage form. The emulsifiers in the m/a cream formula are stearic acid and triethanolamine (TEA). This study aims to determine the physical evaluation of an anti-inflammatory cream containing shallot skin extract with variations in concentrations of TEA and stearic acid. The method used in this study is the experimental method. Formulations I, II, and III with varying concentrations of TEA and stearic acid (2:8%, 3:10%, and 4:12%) were used. Tests carried out included organoleptic tests, homogeneity, pH, spreadability, and adhesion. The cream formula passed the organoleptic test with a distinctive shallot smell, semi-solid form, brownish red color, all formulas were homogeneous, pH 5.264-6.417, spreadability 3.849-6.251 cm, and adhesion 83-132 seconds. Higher concentrations of TEA and stearic acid had an effect on adhesion and spreadability but had no effect on organoleptic properties, homogeneity, or pH. Onion skin extract cream with a concentration of TEA:2%:8% stearic acid gave the best physical quality.
PROFIL PENGETAHUAN PENDUDUK TERHADAP OBAT GENERIK, MEREK DAN PATEN Rissa, Mexsi Mutia; Puspita, Nabila Ayu
Jurnal Riset Kefarmasian Indonesia Vol. 5 No. 1 (2023): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v5i1.339

Abstract

Republic of Indonesia Law Number 36 of 2009 states that medicine is a combination of ingredients, including biological products that are used to affect or investigate physiological systems or pathological conditions in the framework of establishing a diagnosis, prevention, cure, recovery, health promotion and contraception for humans. Generic drugs are drugs whose patents have expired, so all pharmaceutical companies can produce them without the need to pay for patents. Branded drugs are drugs that are marketed under certain trade names registered by the manufacturer. Patented drugs are drugs that have just been produced and marketed by a pharmaceutical company that has had patents for 20 years. The purpose of this study was to determine the profile of the population's knowledge of generic drugs, branded drugs, and patent drugs. The descriptive observational research method by collecting primary data through questionnaires. The results of the study showed that 45 respondents (64.70%) had enough knowledge and 25 respondents (35.70%) had less knowledge. This shows that the profile of the population's knowledge of generic drugs, branded drugs, and patent drugs is considered quite good. The conclusion of this study is that the population's knowledge profile of generic drugs, branded drugs, and patented drugs is included in the sufficient category, namely 64.70%.

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