Indonesian Journal of Pharmaceutical Education
Vol 3, No 1 (2023): Januari-April 2023

Formulasi dan Evaluasi Stabilitas Fisik Sediaan Krim Senyawa Astaxanthin

Robert Tungadi (Jurusan Farmasi, Fakultas Olahraga dan Kesehatan, Universitas Negeri Gorontalo, Gorontalo, Indonesia)
Mahdalena Sy. Pakaya (Jurusan Farmasi, Fakultas Olahraga dan Kesehatan, Universitas Negeri Gorontalo, Gorontalo, Indonesia)
priliya wati d.as'ali (Jurusan Farmasi, Fakultas Olahraga dan Kesehatan, Universitas Negeri Gorontalo, Gorontalo, Indonesia)



Article Info

Publish Date
08 Mar 2023

Abstract

This study aims to formulate and evaluate the preparation of an anti-aging cream made from astaxanthin. Astaxanthin has antioxidant activity, as well as other carotenoid compounds. Astaxanthin shows more significant antioxidant activity than ?-carotene; thus,developing astaxanthin compounds in cream preparations is necessary. This type of experimental laboratory research compares three different concentrations of astaxanthin compounds, including formula I (0.5%), formula II (0.75%), and formula III (1%). Evaluation of the astaxanthin compound cream preparations stability included organoleptic observations (smell, color, texture), pH test, homogeneity test, viscosity test, spreadability test, adhesion test, and freeze-thaw test. The results of the quality inspection of organoleptic preparations revealed no difference between the preparations in the form of color, smell, and texture.The homogeneity test showed a homogeneous preparation; the pH test produced was 5.5-5.8, the viscosity test of the preparation produced was 5140 Cp, 5250 Cp, and 7000 Cp, the adhesion test was 6.40-7.83 seconds, the dispersion test was 5-5.9 cm, and the Freeze-thaw test showed that there was no significant change in the pH test, organoleptic test, spreadability, adhesion, homogeneity, and viscosity. Thus, it can be concluded that the three astaxanthin compound cream formulas have good stability.

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Journal Info

Abbrev

ijpe

Publisher

Subject

Biochemistry, Genetics & Molecular Biology Chemistry Materials Science & Nanotechnology Medicine & Pharmacology

Description

ndonesian Journal of Pharmaceutical Education (IJPE) adalah junal resmi yang diterbitkan oleh Jurusan Farmasi Universitas Negeri Gorontalo yang bekerja sama dengan IAI (Ikatan Apoteker Indonesia) Provinsi Gorontalo. Artikel pada jurnal ini dapat diakses dan unduh secara online oleh publik (open ...