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All Journal Sainstek Jambura FIsh Processing Journal Jurnal Ilmu Kefarmasian Indonesia Journal Syifa Sciences and Clinical Research (JSSCR) Jurnal Sibermas (Sinergi Pemberdayaan Masyarakat) Journal of Experimental and Clinical Pharmacy (JECP) Indonesian Journal of Pharmaceutical Education Jurnal Pengabdian Masyarakat Farmasi : Pharmacare Society Jurnal Farmasi Teknologi Sediaan dan Kosmetika (JFTSK) Journal of Pharmacology and Natural Products
Robert Tungadi
UNIVERSITAS NEGERI GORONTALO
Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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EVALUASI KESTABILAN FISIK KRIM TABIR SURYA DARI BAHAN ALAM YANG MENGGUNAKAN KOMBINASI SURFAKTAN ANIONIK DAN NONIONIK Tungadi, Robert
Sainstek Vol 6, No 3, 2011
Publisher : Jurnal Sainstek

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (8.854 KB)

Abstract

Telah dilakukan uji kestabilan fisik krim tabir surya dari bahan alam yaitu rimpang kencur, rimpang temu giring dan daun teh yang diformulasikan dengan menggunakan surfaktan anionik (trietanolamin-stearat) dengan konsentrasi 0,5%, 1%, 1,5%, 2%, dan 2,5% yang dikombinasi masing-masing dengan surfaktan nonionik (span 60-tween60) dengan konsentrasi 2,5%, 2%, 1,5%, 1% dan 0,5%. Tujuan penelitian ini untuk mendapatkan formulasi krim tabir surya dari bahan alam tipe emulsi m/a yang paling stabil. Evaluasi yang dilakukan meliputi pengamatan perubahan organoleptis yaitu perubahan warna dan bau serta evaluasi kestabilan krim meliputi volume kriming, perubahan kekentalan dan ukuran tetes terdispersi serta inversi fase yang dilakukan sebelum dan setelah krim diberi kondisi penyimpanan dipercepat selama 12 jam secara bergantian pada 5o dan 35oC sebanyak 10 siklus. Hasil pengamatan organoleptis memperlihatkan terjadi perubahan warna dan bau pada kombinasi surfaktan anionik 2% dengan nonionik 1%, dan pada kombinasi surfaktan anionik 2,5% dengan nonionik 0,5%. Pengukuran kekentalan menunjukkan terjadi perubahan kekentalan sebelum dan setelah kondisi penyimpanan dipercepat. Analisis statistik menunjukkan adanya pengaruh yang nyata konsentrasi kombinasi surfaktan anionik-nonionik terhadap kekentalan krim tetapi menunjukkan pengaruh yang tidak nyata terhadap ukuran tetes terdispersi. Hasil pengamatan menunjukkan tidak adanya volume kriming dan inversi fase pada semua formula krim. Krim tabir surya tipe emulsi m/a yang paling stabil adalah krim dengan kombinasi surfaktan anionik 1,5% dan surfaktan nonionik 1,5%. The study concerning the pyhsical stability test of sunscreen cream from natural sources i.e Kaempheriae Rhizoma, Curcumae Heyneanae Rhizoma and Theae Folium which formulated with using anionic surfactan (Triethanolamin-stearic) at 0.5%. 1%. 1.5%, 2% and 2.5% and combined with nonionic surfactant t 2.5%, 2%, 1.5%, 1% and 0.5% respectively. The aim of this research were to get the most stable o/w type emulsion sunscreen cream formulation from natural sources. Cream evaluation including organoleptic changes in colour and odor, and also physical stability of cream i.e creaming volume, viscosity changes, droplets dispersed size changes and phase inversion were evaluated before and after stress condotion which was conducted between 5oC and 35oC alternately, every 12 hours for 10 cycles. The organoleptic observation indicated that there were changes of colour and odor from cream within combination anionic surfactant at 2% nonionic surfactant at 1% and combination anionic surfactant at 2.5% nonionic surfactant at 0.5%. The measurement of viscosity showed there were viscosity changes before and after stress condition. The statistical analysis showed there were significantly different of combination anionic-nonionic surfactant concentration toward the viscosity of cream, but showed unsignificantly different toward the dispersed droplets size. The observation showed there was not creaming and phase inversion to all of the cream. The most stable o/w type emulsion of sunscreen creams were cream using combination of anionic surfactant 1.5% and nonionic surfactant 1.5%.
Formulasi, Karakterisasi, Dan Evaluasi Drops Liquid Self Nano-Emulsifying Drug Delivery System (SNEDDS) Astaxanthin Robert Tungadi; Nur Ain Thomas; Wanda Gita Van Gobel
Indonesian Journal of Pharmaceutical Education Vol 1, No 3 (2021): September-Desember 2021
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v1i3.11400

Abstract

SNEDDS are isotropic mixtures of oil, surfactant, and cosurfactant that produce spontaneous nanoemulsions once they make contact with gastric juices in order to increase the solubility of active pharmaceutical ingredients. One of the active pharmaceutical ingredients with low solubility is Astaxanthin. This research aims at formulating, characterizing, and evaluating SNEDDS containing Astaxanthin in the form of droplets. This research is a laboratory experiment. SNEDDS containing Astaxanthin droplets are made in 3 formulas using the ratio of surfactants and co-surfactants which are characterized to produce F1, F2, and F3 transmittance values of 91%, 90%, and 95%, respectively. Furthermore, the F1 particle size value of 183.75 nm obtains a PDI value of 0.272, the F2 particle sizevalue of 195.25 nm obtains a PDI value of 0.341, and the F3 particle size value of 105.75 nm obtains a PDI value of 0.392. This signifies that the absorption efficiency of F1, F2, and F3 are 94.62%, 94.35%, and 95.57%, respectively. The evaluation reveals the insignificant changes in the emulsion viscosities of SNEDDS containing Astaxanthin liquid drop after having received a stability test for 28 days using Paired T. Test data analysis (p0.05). The research findings show that the F3 of 72% surfactant and 18% co-surfactant concentrations are the best formula in producing SNEDDS. It concludes thar the higher the surfactant concentration produced, the greater the ability to, oil droplets resulting in obtaining small partidles and high absorption efficiency.
BIOSINTESIS NANOPARTIKEL PERAK EKSTRAK ETANOL 96% DAUN KELOR (Moringa oleifera) DAN UJI AKTIVITASNYA SEBAGAI ANTIOKSIDAN Fujiana Abd Karim; Robert Tungadi; Nur Ain Thomas
Indonesian Journal of Pharmaceutical Education Vol 2, No 1 (2022): Januari-April 2022
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v2i1.11725

Abstract

Moringa leaf potentially has a high antioxidant becouse it contains secondary metabolite, one of which is quercetin. Therefore, to avoid harmful chemicals in the synthesis of silver nanoparticles, it is made by using a bio reductant of Moringa leaf extract. This study aims to know the optimal temperature in the formation of silver nanoparticles, to characterize the nanoparticle, and to rest the antioxidant AgNPs of Moringa leaf by using the DPPH method. This is a laboratory experimental study. The synthesis of nanoparticles uses a concentration of 0,4% Moringa leaf extract, which is reacted to AgNO3 with a concentration of 1 mM in a ratio of 1:9 at various temperatures of 60oC, 70oC, and 80oC for 30 minutes. The formed nanoparticles are characterized by using UV-VIS spectrophotometry and showing the optimum temperature for nanoparticles formation, which is 80oC. It is then continued to characterize using PSA and showing the average size of nanoparticles at a temperature of 80oC, which is 82,9 nm with a PDI value of 0,225. The result of the calculation of IC50 AgNPs shows that Moringa leaf obtains a value of 61.78 ppm, which is included in the strong category, meanwhile the thick extract of Moringa leaf without the addition of silver nanoparticles obtain a value of 124.41 ppm, which is included in the weak category.
Potensi Ikan Gabus (Ophiocephalus Striatus) Dalam Mempercepat Penyembuhan Luka Robert Tungadi
Jambura Fish Processing Journal VOLUME 1 NOMOR 1, JANUARI 2019
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jfpj.v1i1.4505

Abstract

Ikan gabus (Ophiocephalus striatus) merupakan jenis ikan yang hidup di air tawar dan sudah banyak dikenal oleh masyarakat. Khasiat dan kegunaan ikan gabus telah terbukti secara ilmiah dapat meningkatkan kadar albumin dan daya tahan tubuh serta mempercepat proses penyembuhan luka pasca- operasi. Adapun kandungan gizi dari ikan gabus terdiri dari protein albumin, asam-asam amino, asam lemak tak jenuh dan mineral. Senyawa bioaktif yang berperan dalam mempercepat proses penyembuhan luka adalah albumin, glisin, dan seng (Zn). Penyembuhan luka sangat bergantung pada proses biokimia yang terjadi pada kulit yang melibatkan faktor intrinsik dan ekstrinsik. Proses penyembuhan ini akan dipercepat dengan bantuan dari ekstrak kering ikan gabus yang dirancang dalam bentuk topikal seperti krim atau gel. Baik albumin, glisin dan Zn ini penting untuk penyembuhan luka karena protein ini mampu mengikat Zn dan membawanya dalam plasma darah. Kekurangan Zn mengurangi proses penyembuhan luka. Karena nutrisi ini, dan vitamin lainnya, hadir dalam ekstrak ikan gabus sehingga dapat memicu pembentukan Sel Progenitor Endotel (EPC) dan mempercepat penyembuhan luka. Kehadiran Zn dalam ekstrak ikan gabus kemungkinan menjadi faktor kunci yang berperan dalam penyembuhan luka dan juga meningkatkan nafsu makan anak-anak. Zn adalah mineral penting dalam struktur dan fungsi membran sel. Suplementasi Zn dapat membatasi kerusakan membran yang disebabkan oleh radikal bebas selama peradangan. Selanjutnya, Zn juga terlibat dalam sistem kekebalan tubuh, mulai dari sistem pertahanan oleh kulit hingga regulasi gen dalam limfosit.
Percepatan Penyembuhan Luka oleh Krim Ikan Gabus (Ophiocephalus striatus) terhadap Luka Kulit Kelinci secara Histopatologi ROBERT TUNGADI; FAISAL ATTAMIMI; EVA FIRMINA SABU; EKO NUGRAHA
JURNAL ILMU KEFARMASIAN INDONESIA Vol 9 No 2 (2011): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (603.431 KB)

Abstract

The aims of the study were to investigate the effect of cream containing various concentrations of snakehead fish on the duration of wound recovery and skin histology as compared to control. Samples of the study were nine rabbits divided into three groups for treatment, i.e. group I (0.5%), group II (1%), and group III (2%). Each rabbit in each group was wounded with scalpel as wide as 4 cm2 on the left and right dorsal thigh. Wound on the left dorsal was applied with snakehead fish cream (accordingly to each concentration) and the right dorsal with basic cream as control. The observations were carried out on day 3, day 6 and day 12 by measuring the wound size and taking picture of the wounded area. On the day 12, skin incision were performed on each group to observe histopathology. The data were analyzed statistically by the SPSS 15 program of repeated measures test. The results indicated that group III (2%) had significant effect on wound recovery by decreasing the wound size every day (p < 0.05). The results were confirmed by observing the skin histopathology, indicating that cream containing 2% snakehead fish could faster improve the tissue granulation as compared to the 0,5% and 1% concentration. It can be concluded that the application of 2% snakehead fish cream for 12 days can accelerate the wound recovery.
Moringa Oleifera Leaf extract as anti-breast cancer: Narrative Review Magfirah Septiani Yusuf; Robert Tungadi
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.14218

Abstract

Breast cancer is a malignant tumor that attacks the cell tissue in the breast but breast cancer therapy can cause cancer cells to spread through the blood vessels to other parts. Ttherefore, there is a need for effective treatment to prevent the spread of cancer cells which is one of them by suppressing cancer cells sel. Moringa leaves contain flavonoid compounds that can be efficacious as anti-breast cancer. This review examines the potential of moringa oleifera as an anticancer of the breast in different concentrations. National and international literature studies include identification and data download of articles and scientific journals using internet sources from the PubMed, Google Scholar, PubMed, and Science Direct databases using keywords Breast Cancer, Flavonoids, Apoptosis, Moringa Leaf Extract. Although further pre-clinical studies still need to be done, the results of this review show Moringa Leaf Extract is effective against inhibiting cancer cell proliferation and triggering apoptosis.
Formulasi dan Evaluasi Sabun Padat Transparan dari Ekstrak Bunga Rosella (Hibiscus sabdariffa L.) Robert Tungadi; Madania Madania; Baiq Husnul Aini
Indonesian Journal of Pharmaceutical Education Vol 2, No 2 (2022): Mei-Agustus 2022
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v2i2.14060

Abstract

Rosella flower is a plant with an antioxidant effect because it contains anthocyanins included in the flavonoid group. Therefore, it is essential to develop rosella flower extract in the form of soap preparations. This present work formulated and evaluated transparent solid soap preparations with 70% ethanol extract. This laboratory experimental research analyzed transparent solid soap preparations that were made of three formulas with different concentrations of active substances, namely FI (0.5%), FII (1%), FIII (2%). In addition, the evaluation of solid soap preparations involved organoleptic observations (smell, color, shape), pH test, foam height test, and irritation test on volunteers' skin. The results of quality inspection of organoleptic preparations indicated that the higher the concentration of the active substance in solid soap preparations, the less transparent the soap looks; the pH test produced 10.63-11.43; the initial foam height test resulted in 80 mm, and the final rest got 70 mm, 60 mm, and 50 mm; skin irritation tested to volunteers showed a negative reaction. The formulation in this study was formula 1, which produced the best transparent soap. It is concluded that FI, FII, and FIII soap with 70% ethanol extract of rosella flowers can be formulated as transparent solid soap.
Pengaruh Variasi Konsentrasi Ekstrak Buah Mahkota Dewa (Phaleria macrocarpa) Terhadap Stabilitas Fisik Sediaan Krim Nur Ain Thomas; Robert Tungadi; Dizky Ramadani Putri Papeo; Andi Makkulawu; Yuni Sarah Manoppo
Indonesian Journal of Pharmaceutical Education Vol 2, No 2 (2022): Mei-Agustus 2022
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v2i2.13532

Abstract

God's crown is one of the plants with various components with flavonoid as one of these components, which is an abundant plant metabolite component in nature that significantly functions for the plant's growth and antioxidants. This study aimed to examine The Concentration Variation Effect of 70% Ethanol Extract from God's Crown (Phaleria Macrocarpa) Towards The Physical Stability of Cream Preparations by variating the extract concentration. The formula concentration on the extract consists of FI (1%), FII (3%), FIII (5%), by stearic acid, paraffin liquid, alcohol cetyl, paraben propyl for the oil phase, aquadest, triethanolamine (TEA), and methylparaben for the water phase. Further evaluations include organoleptic test (smell, color, texture), pH test, homogeneity test, viscosity test, distribution test, and adhesion test. Each evaluation result found changes as intended by the research purpose, which is the effect of the extract's concentration variation on the physical stability of the cream preparations.
Effect of HEC (Hydroxyethyl Cellulose) Polymer on Nanoemulsion-Based Curcumin Transdermal Patch Release Rahmatia Is. Kaluku; Robert Tungadi; Nur Ain Thomas
Indonesian Journal of Pharmaceutical Education Vol 2, No 3 (2022): September-Desember 2022
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v2i3.12025

Abstract

Curcumin a hydrophobic polyphenolic compound and water-insoluble that creates low systemic bioavailability inside the body, has broad pharmacological activity, including anti-inflammation. This study aims to formulate, characterize and evaluate the nanoemulsion based on curcumin through an in vitro transdermal patch preparation. This study starts from formulating a curcumin nanoemulsion solution and characterizing the particle size of curcumin through PSA (Particle Size Analyzer). Further, it formulates the transdermal patch preparation with the smallest curcumin particles within three concentrations (HEC 0,625%, 1,25%, and 2,5%) combined with HPMC 2,5% as polymer. Those formulations are evaluated through organoleptic, thickness, weight uniformity, humidity, and folding resistance tests. In the next step, this study examines the penetration through an in vitro by using a franz diffusion cell within 72 hours. The result shows increasing penetration on each formula where the best penetrations occur in the 15th and 24th hours. It also discovers that the formula containing HEC 2,5% (2c) creates the highest cumulative drug penetration (15,83%). Therefore, it deduces that curcumin nanoemulsion in the transdermal patch has good characteristics and is compatible between drug and polymer.
Edukasi Tentang Vaksin Covid-19 Pada Masyarakat Desa Buata, Bone Bolango, Provinsi Gorontalo Teti Sutriyati Tuloli; Robert Tungadi; Ariani Hutuba; Zulfiayu Sapiun
Jurnal Pengabdian Masyarakat Farmasi : Pharmacare Society Vol 1, No 2 (2022): Vol 1 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (515.114 KB) | DOI: 10.3731/phar.soc.v1i2.16814

Abstract

The World Health Organization (WHO) has declared COVID-19 as a Global Pandemic so must be handled in accordance with the legislation. Vaccination is the most effective and efficient public health effort in preventing some dangerous infectious diseases. Even though, it is undeniable that there are still many community groups who refuse vaccination due to a lack of public knowledge regarding the Covid-19 vaccine. This community service Program aims to increase public knowledge about Covid-19 through education with leaflets and and direct socialization to the Buata village community, Botupinge District, Bone Bolango Regency. The results of the Service Implementation show that the Buata village community is very interested in the information conveyed about Covid-19. This is indicated by the presence of various questions about what is the definition of a vaccine, what are the types of Covid-19 vaccines, and what are the side effects of the Covid-19 vaccine. This question has been answered properly and clearly so that the community feels satisfied and very enthusiastic during the implementation of community service programme.
Co-Authors Akhyar Akhyar Andi Makkulawu Andy, A Mu’thi Anggai, Rifka Anggraini Ariani H. Hutuba Awalludin Awalludin, Awalludin Ayu Maloho, Sity Nur Rahayu Maloho Baiq Husnul Aini Dr. Apt. Hamsidar Hasan S.Si.,M.Si EKO NUGRAHA Endah Nurrohwinta Djuwarno EVA FIRMINA SABU FAISAL ATTAMIMI Fika Nuzul Ramadhani Fujiana Abd Karim Hiola, Dewi Suryaningsi Hiola, Faramita Hutuba, Ariani H Kahar, Oktaviani Madania, Madania Madania, Madania Magfirah Septiani Yusuf Magfirah, Rima Mahdalena Sy Pakaya Mohamad Aprianto Paneo moito, salsa MUHAMMAD TAUFIK Muhammad Taupik Mumtazah, Naharil Njotowidjojo, Dyah Muliawati Nur Ain Thomas Nurkamiden, Firman Pakaya, Juniarista Jessica Papeo, Dizky Ramadani Putri priliya wati d.as&#039;ali Rahmatia Is. Kaluku Ramly Abudi Reski Manno, Mohamad Ruswandi, Edy Samsi, Khairun nisha Sapiun, Zulfiayu Suleman Ibrahim Suryadi, A. Mu'thi Andy Teti Sutriyati Tuloli Tomu, Anita Faradiana Pratiwi R. Wanda Gita Van Gobel Widy Susanti Abdulkadir Yuni Sarah Manoppo