Wounds are damage or loss of body tissue due to a factor that interferes with the body's protection system. These factors include trauma, temperature changes, chemicals, explosions, electric shock, or animal bites. mangroves can be used for medicine because there are several compounds such as alkanoids, flavonoids, steroids, difenoid and sapronin.This study used 30 rats divided into five groups, namely K-groups were only given normal saline, K + was given silver sulfadiazine, P1, P2 and P3 were given mangrove extract with concentrations of 20%, 40% and 80% respectively. This research was conducted for 14 days. Before the mice were given cuts on the back and then treated. The wound healing process macroscopically between the administration of silver sulfadiazine with extracts of mangrove bark with various concentrations of 20%, 40% and 80% in Wistar strain male rats (Rattus norvegicus), concluded that the administration of magrove bark extract (Buguiera gymnorrizha) has an effect on the healing process of wounds in male white mice (Rattus norvegicus) wistar strain because the value of p = 0,000 was obtained pvalue
                        
                        
                        
                        
                            
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