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All Journal Medula Juke Berkala Kedokteran SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Prosiding Seminar Nasional Pakar JK Unila (Jurnal Kedokteran Universitas Lampung) Majority JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Soraya Rahmanisa
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Control & Systems Engineering Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Steroid Sex Hormone And It's Implementation to Reproductive Function Soraya Rahmanisa
JUKE Unila Vol 4, No 07 (2014)
Publisher : Fakultas Kedokteran Universitas Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (340.268 KB)

Abstract

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The Effect of Ethanol Extract 96% o Brown Rice Bran to the Number and Viability of White Rat (Rattus norvegicus) Spermatozoa Sprague dawley Strains Induced by Clove Cigarette Smoke Soraya Rahmanisa; Natasya Hayatillah; Evi Kurniawaty
Berkala Kedokteran Vol 14, No 2 (2018)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (410.169 KB) | DOI: 10.20527/jbk.v14i2.5327

Abstract

Abstract: Indonesia has the greatest number of smokers in Southeast Asia dominated by male consume kretek cigarette. Cigarette’s smoke is source of free radicals that can cause oxidative stress to sperm and lead it to infertility. Red rice bran extract has lot of potential antioxidants to stop oxidatif stress. This study was experimental within 30 days. The 25 Sprague dawley male rats divided into 5 groups: K1 wasn’t treated, K2,P1,P2, and P3 exposed to smokes of 2 kretek cigarettes, given 96% ethanol extract of red rice bran dosage 100 mg/Kg (P1), 200 mg/Kg (P2) and 400 mg/Kg (P3). Spermatozoa number and viability was observed. Data tested with One Way Anova. There was significant effect from red rice bran extract toward sperm number and viability (p=0,00). Average spermatozoa number was 91.90±7.72 (K1), 39.68±7,51 (K2), 79.88±8.63 (P1), 86.40±10.5 (P2), 86.00±5.78 (P3). Average viability was  65.00±6.85 (K1), 29.6±5.85 (K2), 51.4±3.50 (P1), 60.00±6.67 (P2), 61,00±2.91 (P3). The increasing of number and viability has been achived at dose 100mg/Kg and best at 400 mg/KgBB. The 96% ethanol extract of  red rice bran can prevent the decreasing number and viability of rat spermatozoa exposed by kretek cigarette. Keywords: Clove cigarette, spermatozoa, rice bran extract
PERBANDINGAN TINGKAT KESEMBUHAN LUKA SAYAT TERBUKA ANTARA PEMBERIAN ETAKRIDIN LAKTAT DAN PEMBERIAN PROPOLIS SECARA TOPIKAL PADA TIKUS PUTIH (Rattus norvegicus) Evi Kurniawaty; Charla Gutri Farmitali; Soraya Rahmanisa; Silvia Andriani
Prosiding Seminar Nasional Pakar Prosiding Seminar Nasional Pakar 2018 Buku I
Publisher : Lembaga Penelitian Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25105/pakar.v0i0.2657

Abstract

Luka merupakan salah satu proses hilangnya komponen jaringan secaraspesifik yang mengenai bagian tubuh tertentu, contohnya luka sayat(Vulnus scisum) adalah salah satu jenis trauma yang sering terjadi, berbagaimacam cara penyembuhan luka salah satunya dengan penggunaan ethakridinlaktat dan propolis. Penelitian ini bertujuan untuk mengetahui perbandingantingkat kesembuhan luka sayat antara pemberian ethakridin laktat denganpemberian propolis pada tikus putih (Rattus norvegicus). Penelitianeksprimental ini menggunakan metode rancangan acak terkontrol denganpola test only controlled group design terhadap 12 ekor tikus putih yang diberi 3perlakuan selama 7 hari, perlakuan ini terdiri atas kelompok kontrol,kelompok ethakridin laktat, dan kelompok propolis. Hasil yangdidapat merupakan gambaran klinis dan histopatologi. Hasil penelitianmenunjukan uji Pairwise Comparisons pada pemeriksaan mikroskopik danklinis bermakna <0,05 (0,001) antara propolis dan Ethakridin laktat.Kesimpulan penelitian ini adalah terdapat perbedaan yang bermakna antarapemberian ethakridin laktat dan propolis yaitu tingkat kesembuhan propolis,yaitu lebih cepat dibanding ethakridin laktat.
Efek Protektif Pemberian Kombinasi Zinc dan Tomat (Solanum Lycopersicum L) terhadap Histologi Hepar Tikus Putih (Rattus Norvegicus) Galur Sprague Dawley Akibat Stres yang Terpapar Gelombang Elektromagnetik Ponsel Soraya Rahmanisa1, Neza Ukhalima Hafia Sudrajat1 Soraya Rahmanisa; Neza Ukhalima Hafia Sudrajat
Jurnal Kedokteran Universitas Lampung Vol 1, No 3 (2017): JK UNILA
Publisher : Fakultas Kedokteran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jk unila.v1i3.1713

Abstract

Paparan radiasi gelombang elektromagnetik ponsel dapat menyebabkan stres oksidatif yang akan menimbulkan kerusakan sel hepar. Zinc dan tomat memiliki khasiat sebagai antioksidan. Penelitian ini bertujan untuk mengetahui efek protektif kombinasi zinc dan tomat terhadap gambaran histologi hepar tikus putih (Rattus norvegicus) galur Sprague dawley akibatstres yang terpapar gelombang elektromagnetik ponsel. Penelitian eksperimental dengan menggunakan 25 ekor tikus yang dibagi menjadi 5 kelompok. Kelompok kontrol 1 (K1) hanya diberi makan dan minum, kelompok kontrol 2 (K2) diinduksi paparan ponsel, kelompok perlakuan (P1), (P2), (P3) diberikan kombinasi zinc dan tomat dengan dosis (P1): tomat 1,85g dan zinc 0,54mg; (P2): tomat 3,7g dan zinc 0,27mg; (P3): tomat 7,4g dan zinc 0,135mg; dan diinduksi paparan ponsel 2 jam/hari selama 35 hari. Rerata kerusakan sel hepatosit yang mengalami degenerasi bengkak keruh pada K1=0,4; K2=3,36; P1=1,2; P2=1,52; P3=1,8. Data diuji dengan uji One Way ANOVA dan didapatkan hasil p=0,006 (p<0,05). Selanjutnya, dengan uji Post Hoc didapatkan p antara K1 vs K2= 0,003; K2 vs P1= 0,049; K2 vs P2= 0,140; K2 VS P3= 0,336. Pemberian kombinasi zinc dan tomat dapat memperbaiki gambaran histologi hepar tikus putih pada kelompok P1. Kata kunci: gelombang elektromagnetik, hepar, tomat, zinc
Pengaruh Pemberian Ekstrak Kulit Batang Bakau Minyak (Rhizophora apiculata) Etanol 95 % terhadap Arteri Koronaria Tikus Putih (Rattus novergicus) Jantan Galur Sprague dawley yang Dipaparkan Asap Rokok Syazili Mustofa; Nicholas Alfa; Anggraeni Janar Wulan; Soraya Rahmanisa
Jurnal Kedokteran Universitas Lampung Vol 3, No 1 (2019): JK Unila
Publisher : Fakultas Kedokteran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jk unila.v3i1.2200

Abstract

Indonesia menenmpati peringkat pertama sebagai negara dengan jumlah perokok terbesar di kawasan ASEAN. Hal ini tentunya sangat memprihatinkan 2 dari 3 orang Indoneisa merupakan seorang perokok. Penyakit jantung koroner (PJK) merupakan penyebab kematian tertinggi di Indonesia setelah stroke, yakni 12,9%. Rhizophora apiculata memiliki kandungan tanin, alkaloid, dan flavonoid yang dapat mencegah radikal bebas. Dari uraian diatas, penulis ingin menggali potensi antioksidan yang terdapat dalam bakau dengan mempelajari pengaruh pemberian ekstrak kulit bakau minyak (Rhizophora apiculata) dalam melindungi arteri koroner tikus dari paparan asap rokok. Penelitian ini adalah penelitan eksperimental. Sampel yang digunakan adalah tikus putih jantan (Rattus novergicus) galur Sprague dawley yang terdiri dari 5 kelompok, masing masing kelompok terdiri dari 5 ekor tikus dan 1 cadangan. Dosis ekstrak bakau yang digunakan pada P1 adalah 28,275 mg/kgbb, P2: 56,55 mg/kgbb, P3: 113,1 mg/kgbb. Analisis statistik yang digunakan yaitu uji One Way Anova dengan post hoc Bonferroni. Rerata tebal dinding arteri koronaria memiliki hasil bermakna pada semua kelompok perlakuan. Ekstrak kulit batang bakau minyak (Rhizophora apiculata) mampu melindungi arteri koronaria tikus putih jantan (Rattus novergicus) galur Sprague dawley yang dipaparkan asap rokok. Dosis optimal ekstrak kulit batang bakau minyak (Rhizophora apiculata) dalam mencegah penebalan arteri koronaria tikus putih jantan yang dipaparkan asap rokok adalah 56,55 mg/kgbb. Kata kunci: antioksidan, arteri koronaria, asap rokok, bakau minyak Effect of Giving Mangrove (Rhizophora apiculata)
Hubungan Beban Kerja Mental terhadap kejadian Abortus pada Pekerja Bruruh Pabrik di PT. Great Giant Pineapple Ratna Dewi Puspita Sari; Soraya Rahmanisa; Evriana Citra
Jurnal Kedokteran Universitas Lampung Vol 3, No 1 (2019): JK Unila
Publisher : Fakultas Kedokteran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jk unila.v3i1.2214

Abstract

Abortus merupakan salah satu penyebab kematian ibu, Komplikasi abortus berupa perdarahan atau infeksi dapat menyebabkan kematian. Abortus didefinisikan sebagai ancaman pengeluaran janin sebelum janin bisa hidup di luar kandungan dengan usia kehamilan kurang dari 20 minggu serta berat janin 500 gram. Salah satu faktor penyebab abortus adalah aktifitas yaitu aktifitas fisik dan mental, aktifitas mental dapat menimbulkan beban kerja yaitu beban kerja mental. Tujuan penelian ini adalah untuk mengetahui adanya hubungan beban kerja mental terhadap kejadian abortus. Beban kerja mental dapat menimbulkan stress kerja, Stres dapat mempengaruhi sistem kekebalan tubuh dan endokrin dengan secara langsung mempengaruhi pertumbuhan janin hingga menyebabkan abortus. Penelitian ini merupakan analitik observasional dengan ranncangan cross sectional, Instrumen penelitian adalah kuisioner beban kerja mental NASA tlx. Hasil penelitian berdasarkan uji chi square menunjukkan bahwa p=0,000. Ini menunjukkan bahwa terjadi peningkatan resiko untuk terjadi abortus pada pekerja dengan beban kerja mental yang berat. Disimpulkan bahwa Terdapat hubungan antara beban kerja mental terhadap kejadian abortus pada pekerja buruh pabrik di PT. Grat Giant Pineapple.Kata kunci : Abortion, Mental workload.
Pengaruh Pemberian Ekstrak Kulit BatangMangrove (Bruguiera gymnorrhiza) Dalam Proses Penyembuhan Luka Sayat pada Tikus Putih Jantan (Rattus norvegicus) Galur Wistar Lia Qelina; Soraya Rahmanisa; Rasmi Zakiah Oktarlina
MAJORITY Vol 10 No 1 (2021): MAJORITY
Publisher : Majority

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Wounds are damage or loss of body tissue due to a factor that interferes with the body's protection system. These factors include trauma, temperature changes, chemicals, explosions, electric shock, or animal bites. mangroves can be used for medicine because there are several compounds such as alkanoids, flavonoids, steroids, difenoid and sapronin.This study used 30 rats divided into five groups, namely K-groups were only given normal saline, K + was given silver sulfadiazine, P1, P2 and P3 were given mangrove extract with concentrations of 20%, 40% and 80% respectively. This research was conducted for 14 days. Before the mice were given cuts on the back and then treated. The wound healing process macroscopically between the administration of silver sulfadiazine with extracts of mangrove bark with various concentrations of 20%, 40% and 80% in Wistar strain male rats (Rattus norvegicus), concluded that the administration of magrove bark extract (Buguiera gymnorrizha) has an effect on the healing process of wounds in male white mice (Rattus norvegicus) wistar strain because the value of p = 0,000 was obtained pvalue
Penerapan DNA Rekombinan Dalam Terapi Gen Ardandi, Rofi Yoga; Nurhaliza, Suci; Poty, Pitha Maykania; Sha, Nindy Putri; Rahmanisa, Soraya
Medula Vol 14 No 5 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i5.930

Abstract

Recombinant DNA technology is the fusion of genetic material from two different sources. Recombinant DNA refers to combining genetic material from two different sources to create a new organism or to produce a specific protein. The main purpose of genetic recombination is to produce more evolved and adapted organisms, as well as develop biotechnology strategies, such as recombinant protein production. This technology is applied in clinical and medicine such as vaccines. Recombinant vaccines are made by utilizing recombinant DNA technology, which is a gene cloning technique that is modified to produce the specific protein product sought. Gene cloning is a procedure by which foreign DNA or genes are inserted into a host cell using a vector. Gene cloning involves the insertion of a gene of interest into a vector, resulting in the creation of recombinant DNA that can replicate within the host cell, an example being the SARS-CoV-2 DNA vaccine. Oncolytic virus, Gendicine, Modified Virus Ankara (MVA) are recombinant DNA technologies for cancer therapy. The advantages of this therapy are its ability to form new combinations of genetic material by insertion of molecules; DNA recombination technology allows the production of large quantities of certain protein molecules, which can be used in the manufacture of drugs; the production of therapeutic substances by strains of organisms can be achieved through the use of recombinant DNA technology; drugs that have unique properties that are difficult or impossible to obtain through traditional approaches can be made through DNA recombination; and DNA recombination plays an important role in drug manufacturing by facilitating the synthesis of therapeutic molecules important for human health. The disadvantages are that it has a negative impact on the environment, requires strict supervision to ensure safety and security, and ethical controversies. This technology has many benefits, but it is necessary to consider some of the disadvantages and adverse effects that can be caused.
Diabetes Mellitus Tipe 1 Fauziani, Andra Nabila; Adelia, Anggi; Ardika, Okta Besti; Himayani, Rani; Rahmanisa, Soraya
Medula Vol 14 No 3 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i3.946

Abstract

Diabetes mellitus (DM) is a chronic condition with an increasing incidence worldwide. Not only does it occur in adults, but the incidence rate in children is also quite high. Type-1 DM is an autoimmune disease characterized by absolute insulin deficiency due to pancreatic gland cell damage. Although it can occur at any age, type-1 DM most commonly appears in adolescence with a peak onset around puberty. Diabetes mellitus is often caused by genetic factors and a person's lifestyle. Symptoms of Type 1 DM in children are the same as in adults: polyphagia, polydipsia, polyuria and nocturia, weight loss, and about a third suffer from diabetic ketoacidosis. Complications of diabetes can be divided into microvascular and macrovascular. Microvascular complications include nervous system damage (neuropathy), renal system damage (nephropathy) and eye damage (retinopathy), but can also affect cognitive function, heart and other organs. HbA1c screening is recommended every 3 to 6 months. HbA1c levels reflect glycemic control over the previous 2-3 months. The target HbA1c is generally <7.0%. Other laboratory tests include lipid profile, serum creatinine, eGFR, and urine albumin to creatinine ratio. Management of Type 1 DM includes insulin injection, blood sugar monitoring, nutrition, physical activity, and education. The goal of insulin therapy is to ensure that insulin levels in the body are sufficient for 24 hours to meet metabolic needs due to the glycemic effect of food.
Review Literature: Relationship of Food Intake and the Incidence of Dyspepsia Syndrome in Medical Students Napitupulu, Cindy Cecilia Anasthasya; Rahmanisa, Soraya; Happy, Terza Aflika; Sari, Ratna Dewi Puspita
Medula Vol 15 No 1 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i1.1443

Abstract

Dyspepsia syndrome is a digestive disorder characterized by symptoms such as epigastric pain, burning, bloating and nausea. In Indonesia, the prevalence is high, with most cases classified as functional dyspepsia. In medical students, poor and irregular diets are common due to academic pressure, busy schedules, and unhealthy lifestyles, which are thought to be the main risk factors for dyspepsia. These habits are further exacerbated by the consumption of unhealthy foods, such as fast food, as well as the habit of eating at irregular times. This study aimed to evaluate the relationship between diet and the incidence of dyspepsia syndrome in medical students in Indonesia through a literature review. A literature search was conducted online using Google Scholar with the keywords “dyspepsia syndrome,” “medical student dyspepsia syndrome,” and “medical student diet.” Of the 635 articles found, 16 were screened based on relevance of content, availability of full text, use of Indonesian language, and time of publication within the last 5 years. Five relevant articles were selected for further review. The review showed a significant association between disordered eating patterns and the incidence of dyspeptic syndrome. Habitual skipping of breakfast, consumption of fast food, eating under stressful conditions, and lack of balanced nutritional intake contributed to the risk of dyspepsia. This conclusion emphasizes the importance of health education on regular diet, stress management, and healthy lifestyle to prevent dyspepsia syndrome and improve the quality of life of medical students.
Co-Authors Adelia, Anggi Anggraeni Janar Wulan Ardandi, Rofi Yoga Ardika, Okta Besti Charla Gutri Farmitali Dian Isti Angraini Eka Putri Rahmadhani Evi Kurniawaty Evriana Citra Fauziani, Andra Nabila Giska Tri Putri Happy, Terza Aflika Husnandari, Aqila Leni Amelia Lia Qelina Napitupulu, Cindy Cecilia Anasthasya Natasya Hayatillah Neza Ukhalima Hafia Sudrajat Nicholas Alfa Novita Carolia Nurhaliza, Suci Poty, Pitha Maykania Ramadhana Komala Rani Himayani Rasmi Zakiah Oktarlina Ratna Dewi Puspita Sari Reni Zuraida Sha, Nindy Putri Silvia Andriani Sofyan Musyabiq Wijaya Syazili Mustofa Wiwi Febriani Yunianto, Andi Eka