UJI ANTIINFLAMASI EKSTRAK ETANOL BIJI PETAI (PARKIA SPECIOSA HASSK.) TERHADAP MENCIT PUTIH (MUS MUSCULUS) JANTAN YANG DIINDUKSI KARAGENIN

Latipah Latipah (Program Studi S1 Farmasi, Universitas Muhammadiyah Banjarmasin)
Rizka Mulya Miranti (Fakultas Farmasi, Universitas Muhammadiyah Banjarmasin)
Tuty Mulyani (Fakultas Farmasi, Universitas Muhammadiyah Banjarmasin)

Journal of Innovation Research and Knowledge
Vol. 3 No. 9: Februari 2024

Petai seeds contain phenolic compounds, flavonoids, terpenoids, and steroids which are thought to have a role in anti-inflammatory effect. In this study, the anti-inflammatory effect of petai seed extract was tested using the paw edema method induced by 1% carrageenin. The test was carried out by dividing 5 groups, namely negative control, positive control and ethanol extract of petai seeds with doses of 100,200 and 300 mg/kgBW. In this study, there were 4 test parameters, namely the percent edema, AUC (Area Under Curve), the percent inhibition of inflammation, and the percent relative potential of anti-inflammatory power. The test data were analyzed by analysis of variance (ANOVA) then followed by the Post Hoc test using the LSD (Least Square Differences) method with a 95% confidence level to see the differences between treatments. Based on the results of these tests, the results stated that the administration of ethanol extract of petai seeds had anti-inflammatory power with the best dose of 300 mg/kgBB.