The family is the closest unit to the patient, and is the main caregiver for the patient. Humans as social beings cannot live alone without the help of others. The purpose of this study was to determine the effect of family therapy on adherence to taking medication in patients with mental disorders with low self-esteem in the Salobulo Health Center Working Area, Sajoanging District. Social support is very important for the treatment and recovery of low self-esteem patients. If there is no social support, the patient cannot play a role according to the expectations of his environment, so that if the patient is declared cured and returns to his environment, he will be treated again on the grounds that his behavior is not accepted by his family and environment. This type of research uses quantitative research with a Cross Sectional Study approach to determine the relationship between family therapy and the level of compliance with taking medication in patients with low self-esteem mental disorders. The results showed that there was a relationship between family therapy and adherence to taking medication in patients with low self-esteem mental disorders in the Salobulo Health Center Working Area, Sajoanging District. This is based on the results of the Chi-Square test obtained p Value = 0.016 (p < ?), which means that Ha is accepted and H0 is rejected, namely there is a relationship between Family Therapy and Adherence to Taking Medication for Low Self Esteem Mental Disorder Patients. Suggestions for families who have family members suffering from mental disorders in order to help family members to continue treatment, increase knowledge about mental health, and improve health status and quality of life. Abstrak Keluarga merupakan unit paling dekat dengan penderita,dan merupakan perawat utama bagi penderita. Manusia sebagai makhluk sosial tidak dapat hidup sendirian tanpa bantuan orang lain. Tujuan penelitian ini adalah Untuk Mengetahui Pengaruh Terapi Keluarga Terhadap Kepatuhan Minum Obat Pada Pasien Gangguan Jiwa Harga Diri Rendah di Wilayah Kerja Puskesmas Salobulo Kecamatan Sajoanging. Dukungan sosial sangat penting terhadap pengobatan dan kesembuhan pasien harga diri rendah. Jika tidak ada dukungan sosial penderita tidak dapat berperan sesuai harapan lingkungannya, sehingga apabila pasien dinyatakan sembuh dan kembali ke lingkungannya akan kembali dirawat dengan alasan perilakunya tidak diterima keluarga dan lingkungannya. Jenis penelitian ini mengggunakan jenis penelitian kuantitatif dengan pendekatan Cross Sectional Study untuk mengetahui hubungan terapi keluarga dengan tingkat kepatuhan minum obat pada pasien gangguan jiwa harga diri rendah. Hasil penelitian menunjukkan bahwa ada hubungan Terapi Keluarga dengan Kepatuhan Minum Obat Pada Pasien Gangguan Jiwa Harga Diri Rendahdi Wilayah Kerja Puskesmas Salobulo Kecamatan Sajoanging. Hal tersebut berdasarkan hasil uji Chi-Square didapatkan p Value = 0.016 (p < ?),yang artinya Ha diterima dan H0 ditolak yakni ada hubungan Terapi Keluarga dengan Kepatuhan Minum Obat Pasien Gangguan Jiwa Harga Diri Rendah bisa membantu anggota keluarga untuk melanjutkan pengobatan, meningkatkan pengetahuan tentang kesehatan jiwa, serta meningkatkan status kesehatan dan kualitas hidup.
                        
                        
                        
                        
                            
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