<![CDATA[The incidence of infections that attack the body's immunity is a major problem in various Country. In 2019, Indonesia was shocked by the occurrence of Coronavirus infection that requires an immediate therapeutic approach. The infection attacks the body's immunity in biological and physiologically there are defense mechanisms that can protect body. Indonesia has abundant biodiversity and become an opportunity in the exploration of natural medicinal ingredients. Guazuma ulmifolia Lamk. is a type of plant and a parasite that is widely found in the highlands and is widely found in Janji Maria Village, North Tapanuli Regency Traditionally, it used for overweight, cholesterol, cancer therapy by boiling and drink it. This study purpose to analyze the activity of extract on IL-1 and IL-2 levels using male rats as test animals by the enzyme-linked immunosorbent assay. The method used is experimentally by measuring IL-1 and IL-2 levels in serum isolated from blood rats that have been given Guazuma ulmifolia Lamk. extract. Guazuma ulmifolia Lamk. extract at doses of 50, 100, 200, and 400 mg/kgBW and quercetin as a marker agent. The levels of IL-1 and IL-2 also increased following treatment with Guazuma ulmifolia Lamk. Extract and quercetin in both groups as compared to the negative control group. The extract at dose of 400 mg/kg BW and quercetin showed higher immunostimulatory activity than levamisole as a positive control. It was concluded that Guazuma ulmifolia Lamk. exhibit immunomodulatory activity, acting as immunostimulatory agent and has potential to be developed as a therapeutic agent.]]>
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