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All Journal JURNAL FARMASIMED (JFM) Science Midwifery
S, Aminah.
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Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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DRP EVALUASI DRUNG RELATED PROBLEMS (DRPs) ANTIBIOTIK PADA PASIEN PNEUMONIA RAWAT INAP ANAK RUMAH SAKIT UMUM DAERAH DELI SERDANG Monica, Cindy; S, Aminah.; Dalilla, Siti
Jurnal FARMASIMED (JFM) Vol 3 No 2 (2021): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v3i2.574

Abstract

Background: Infection is one of the top ten diseases in Indonesia, so that antibiotic therapy is quite high. The increasing use of antibiotics may lead to an increase in the use of irrational antibiotics. Drug Related Problems (DRPs) are events that are not expected from the patient's experience or are suspected to be due to drug therapy so that they have the potential to interfere with the desired healing success. Objective: This study aims to determine the number of occurrences of DRPs which include dosage inaccuracy, namely under and over dose, indication without drug, drug without indication, potential interactions and inaccuracy of drug selection in inpatient pneumonia treatment for children at the Deli Serdang Regional public hospital. In 2019 Method: This study is retrospective in which data is obtained through secondary data in the form of patient medical records for the period January-December 2019 with a cross-sectional study design. The data collection technique was in the form of total sampling, obtained 50 samples that fit the inclusion criteria. Results: Drung Related Problems (DRPs) research that occurred in the under-dose category of drugs (4.0%), and excessive drug doses (2.0%) and no DRPs (94.0%). This shows that the role of pharmacists is important in monitoring patient drug therapy to minimize the occurrence of DRPs.
Effect of guazuma ulmifolia lamk. extract on interleukin-1 and interleukin-2 levels as immunomodulatory agent candidates Sihombing, Yanna Rotua; Marbun, Romauli Anna Teresia; S, Aminah.; Siska, Fitri
Science Midwifery Vol 12 No 4 (2024): October: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v12i4.1714

Abstract

The incidence of infections that attack the body's immunity is a major problem in various Country. In 2019, Indonesia was shocked by the occurrence of Coronavirus infection that requires an immediate therapeutic approach. The infection attacks the body's immunity in biological and physiologically there are defense mechanisms that can protect body. Indonesia has abundant biodiversity and become an opportunity in the exploration of natural medicinal ingredients. Guazuma ulmifolia Lamk. is a type of plant and a parasite that is widely found in the highlands and is widely found in Janji Maria Village, North Tapanuli Regency Traditionally, it used for overweight, cholesterol, cancer therapy by boiling and drink it. This study purpose to analyze the activity of extract on IL-1 and IL-2 levels using male rats as test animals by the enzyme-linked immunosorbent assay. The method used is experimentally by measuring IL-1 and IL-2 levels in serum isolated from blood rats that have been given Guazuma ulmifolia Lamk. extract. Guazuma ulmifolia Lamk. extract at doses of 50, 100, 200, and 400 mg/kgBW and quercetin as a marker agent. The levels of IL-1 and IL-2 also increased following treatment with Guazuma ulmifolia Lamk. Extract and quercetin in both groups as compared to the negative control group. The extract at dose of 400 mg/kg BW and quercetin showed higher immunostimulatory activity than levamisole as a positive control. It was concluded that Guazuma ulmifolia Lamk. exhibit immunomodulatory activity, acting as immunostimulatory agent and has potential to be developed as a therapeutic agent.
Co-Authors Cindy Monica, Cindy Dalilla, Siti Sihombing, Yanna Rotua Siska, Fitri