<![CDATA[Nosocomial infections are a serious issue in Indonesia, with a prevalence of 6–16%. These infections increase morbidity, mortality, hospital stays, and healthcare costs. Infection Prevention and Control (IPC) in hospitals is crucial to reducing the risk of transmission among patients, healthcare workers, and the community. However, IPC program implementation faces challenges such as limited resources, inadequate infrastructure, and noncompliance with protocols. This literature review analyzes the implementation of IPC programs, healthcare workers' adherence to hand hygiene, and factors influencing program success. Data were collected through journal searches using keywords “Nosocomial Infection Prevention,” AND “Infection Control in Hospitals,” OR “Hand Hygiene Compliance.” Findings indicate that Continuous Quality Improvement (CQI) programs and hand hygiene practices effectively reduce nosocomial infections. However, challenges persist in implementing and maintaining IPC programs. Factors such as knowledge, motivation, supervision, and workload play a critical role in determining the success of these initiatives in healthcare facilities]]>
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