The NS1 antigen test is developed to detect dengue virus infection during the acute phase, a stage marked by various hematological abnormalities. An increase in hemoglobin levels greater than 20% can support the diagnosis of Dengue Hemorrhagic Fever (DHF), often caused by hemoconcentration due to plasma leakage, which also raises erythrocyte levels in the bloodstream. This study aimed to examine the relationship between NS1 test results and hemoglobin, hematocrit, leukocyte, platelet, and erythrocyte levels in pediatric DHF patients at Dr. Soedarso Regional Hospital. Using a cross-sectional design with total sampling, 203 samples were collected from suspected pediatric DHF patients between May and July 2023. Data included NS1 results and hematology parameters. The analysis showed a significant association between positive NS1 results and hemoglobin levels (p = 0.025) as well as platelet counts (p = 0.035), but no significant relationship with hematocrit (p = 0.872), leukocytes (p = 0.269), or erythrocytes (p = 0.060). In conclusion, NS1 positivity is significantly associated with hemoglobin levels and platelet count, but not with hematocrit, leukocytes, or erythrocytes in pediatric DHF patients.
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