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All Journal MEDICA (International Medical Scientific Journal)
Herlinda Djohan
Department of Medical Laboratory Technology, Politeknik Kesehatan Kementerian Kesehatan Pontianak, Pontianak, West Kalimantan, Indonesia
Chemistry Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Exploring C-Reactive Protein Levels in Menstruating Female Students: A Descriptive Study Agiesa Khoirunzia; Herlinda Djohan; Linda Triana; Etiek Nurhayati
MEDICA (International Medical Scientific Journal) Vol. 7 No. 1 (2025): MEDICA (International Medical Scientific Journal)
Publisher : Borneo Scientific Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53770/medica.v7i1.482

Abstract

During menstruation, prostaglandins induce uterine contractions, which contribute to the thickening of the endometrial mucosa and the constriction of blood vessels. Elevated levels of prostaglandins may influence C-Reactive Protein (CRP) levels, a marker that increases in response to inflammation or infection as part of the body's immune response. This study aimed to examine CRP levels in female students during menstruation. A descriptive research design was employed to assess CRP levels in menstruating female students. The sample consisted of blood serum collected from 30 students at Madrasah Aliyah Pondok Pesantren Pembangunan Ushuluddin in Singkawang City. The results showed that among the participants, 5 students aged 16 and 1 student aged 15 exhibited positive CRP levels. Regarding the duration of menstruation, positive CRP levels were detected in 4 students on the first day, 1 student on the second day, and 1 student on the third day. Overall, 20% of the students showed positive CRP levels, while 80% had negative CRP levels. The conclusion indicates that a subset of menstruating female students exhibited elevated CRP levels, particularly during the early days of menstruation. This suggests that menstruation, likely through prostaglandin-induced inflammation, may be associated with an increase in CRP levels in some individuals.
The Relationship Between NS1 Examination and the Examination of Hemoglobin, Hematocrit, Leukocytes, Platelets, and Erythrocytes in Dengue Fever Patients in The Pediatric Ward Agus Dimas Ratulangi; Herlinda Djohan; Laila Kamilla
MEDICA (International Medical Scientific Journal) Vol. 7 No. 1 (2025): MEDICA (International Medical Scientific Journal)
Publisher : Borneo Scientific Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53770/medica.v7i1.486

Abstract

The NS1 antigen test is developed to detect dengue virus infection during the acute phase, a stage marked by various hematological abnormalities. An increase in hemoglobin levels greater than 20% can support the diagnosis of Dengue Hemorrhagic Fever (DHF), often caused by hemoconcentration due to plasma leakage, which also raises erythrocyte levels in the bloodstream. This study aimed to examine the relationship between NS1 test results and hemoglobin, hematocrit, leukocyte, platelet, and erythrocyte levels in pediatric DHF patients at Dr. Soedarso Regional Hospital. Using a cross-sectional design with total sampling, 203 samples were collected from suspected pediatric DHF patients between May and July 2023. Data included NS1 results and hematology parameters. The analysis showed a significant association between positive NS1 results and hemoglobin levels (p = 0.025) as well as platelet counts (p = 0.035), but no significant relationship with hematocrit (p = 0.872), leukocytes (p = 0.269), or erythrocytes (p = 0.060). In conclusion, NS1 positivity is significantly associated with hemoglobin levels and platelet count, but not with hematocrit, leukocytes, or erythrocytes in pediatric DHF patients.
Phytochemical Identification and Antioxidant Activity Test of Acetone Extract of Celery Leaves (Apium graveolens L.) Using the DPPH (2,2-diphenyl-1-picrylhydrazyl) Method Riska Auliannisa; Gervacia Jenny; Herlinda Djohan
MEDICA (International Medical Scientific Journal) Vol. 6 No. 3 (2024): MEDICA (International Medical Scientific Journal)
Publisher : Borneo Scientific Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53770/medica.v6i3.488

Abstract

Free radicals are formed in the body through oxidation processes and cell combustion during breathing, metabolism, excessive physical activity, as well as exposure to external pollution. Antioxidants play an important role in protecting the body from oxidative damage. Celery leaves (Apium graveolens L.), which are rich in flavonoid compounds, have the potential to be a natural source of antioxidants. This study aims to identify the secondary metabolite content and measure the antioxidant activity of acetone extract of celery leaves based on IC50 values using the DPPH (2,2-diphenyl-1-picrylhydrazyl) method. The study uses a quasi-experimental design with purposive sampling techniques. The antioxidant activity of acetone extract of celery leaves at concentrations of 30 ppm, 50 ppm, 70 ppm, and 90 ppm was tested using a UV-VIS spectrophotometer at a wavelength of 516 nm. The results showed the presence of secondary metabolite compounds such as alkaloids, flavonoids, phenols, triterpenoids, saponins, and tannins in the acetone extract of celery leaves. The IC50 value of the acetone extract of celery leaves was 115.09490 ppm, indicating moderate antioxidant activity (IC50 value between 100–250 ppm). These findings conclude that acetone extract of celery leaves has potential to be used as a natural antioxidant source.
Co-Authors Agiesa Khoirunzia Agus Dimas Ratulangi Etiek Nurhayati Laila Kamilla Linda Triana Ratnawaty, Gervacia Jenny Riska Auliannisa