The Relationship Between Anti-Tuberculosis Drug Therapy and Uric Acid and Creatinine Levels in Tuberculosis Patients in Kayong Utara District

Selvianty Selvianty (Department of Medical Laboratory Technology, Politeknik Kesehatan Kementerian Kesehatan Pontianak, Pontianak, West Kalimantan, Indonesia)
Ratih Indrawati (Department of Medical Laboratory Technology, Politeknik Kesehatan Kementerian Kesehatan Pontianak, Pontianak, West Kalimantan, Indonesia)
Maulidiyah Salim (Department of Medical Laboratory Technology, Politeknik Kesehatan Kementerian Kesehatan Pontianak, Pontianak, West Kalimantan, Indonesia)

MEDICA (International Medical Scientific Journal)
Vol. 7 No. 2 (2025): MEDICA (Internasional Medical Scientific Journal)

Pulmonary tuberculosis (TB) is a chronic infectious disease caused by Mycobacterium tuberculosis. TB treatment involves five essential drugs: isoniazid, streptomycin, ethambutol, rifampicin, and pyrazinamide. Among these, pyrazinamide and ethambutol are known to potentially increase uric acid and creatinine levels as side effects. This study aimed to examine the relationship between anti-TB drug (OAT) therapy and levels of uric acid and creatinine in TB patients in Kayong Utara District. Using a cross-sectional design and purposive sampling, data were collected from 31 TB patients across three community health centers with the highest TB incidence. Results showed that 54.8% of patients had elevated uric acid levels, while 45.2% had normal levels. For creatinine, 93.5% had normal levels, and 6.5% had elevated levels. Chi-square analysis indicated a significant association between OAT therapy and uric acid levels (p = 0.045), but no significant relationship was found with creatinine levels (p = 1.000). These findings suggest that OAT therapy may affect uric acid levels in TB patients, highlighting the need for monitoring during treatment.