Diabetes mellitus is a syndrome of impaired carbohydrate, fat, and protein metabolism caused by a lack of insulin secretion or reduced tissue sensitivity to insulin. In general, there are several types of diabetes mellitus, one of which is type 2 diabetes mellitus. Depression is a condition of human mood disorders that can affect mind and physical health, characterized by  lack of energy, sadness, insomnia, and an inability to enjoy life. The purpose of this study was to describe the level of depression in patients with type 2 diabetes mellitus at the Endocrine Clinic of Central Public Hospital Dr. M. Djamil Padang.  This study used a quantitative descriptive design. Sampling was done by consecutive sampling technique. Sample in this study were patients diagnosed with type 2 diabetes mellitus who were treated at the Endocrine Polyclinic of Endocrine Clinic of Central Public Hospital Dr. M. Djamil Padang with  total of 60 people. Data were obtained from interviews and medical records of type 2 diabetes mellitus patients in 2023. Data were analyzed univariately.  The result of this study showed the characteristics of T2DM patients, where samples most commonly found in middle adulthood (53,3%), men (56,7%), senior high school (46,7%), housewives (35%), and married status (83,3%). The result also showed that 61,7% of T2DM patients had a normal level of depression, 18,3% of patients had mild depression, 11,7% with moderate depression, and 8,3% with severe depression. Depression mostly occurred in middle adulthood (60,8%), women (65,2%), moderate levels of education (47,8%), housewife (52,2%), married status (73,9%), obese (39,1%), patients with comorbid (69,6%), patients with duration of diagnosis >5 years (69,6%), and patients with complication (52,2%).  The conclusion of this study is that most of the T2DM patients experience normal levels of depression, the highest level of depression found in middle adulthood, women, moderate levels of education, housewife, married status, obese, patients with duration of diagnosis >5 years, and patients with comorbid and complication.
                        
                        
                        
                        
                            
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