Jurnal Farmasi Sains dan Komunitas
Vol 22, No 1 (2025)

Hematology Toxicities in Paclitaxel-Carboplatin Cancer Regiment

Meitasari, Annisa Diyan (Unknown)
Ermawati, Dian Eka (Unknown)
Rohmani, Sholichah (Unknown)
Sasongko, Heru (Unknown)
Zulpadly, Muhammad Fiqri (Unknown)
Utami, Diyah Tri (Unknown)
Susanto, Nindita Clourisa Amaris (Unknown)
Untari, Meta Kartika (Unknown)
Darojati, Ulfa Afrinurfadhilah (Unknown)



Article Info

Publish Date
25 Jun 2025

Abstract

Chemotherapy is one of therapy for patients with cancer. Treatment carboplatin paclitaxel regimen is usually use for cervix, breast, and ovarium cancer. But the data of ADRs in hematology toxicity caused paclitaxel-carboplatin regiment is minimal, so it is required to do research. The aim of this research is can give information about the hematology toxicity, incident, severity, relationship between risk factor due incident of myelosuppression, and relationship between pre post chemotherapy due the myelosuppression. The severity ADRs use CTCAE 5.0. The ADRs were evaluated by severity, descriptive statistics, and some bivariate analysis. Anemia (66.46%) has a highest incident and followed by leukopenia (18.18%), neutropenia (13.22%), and thrombocytopenia (9.09%). Type of cancer associate with incident of anemia, leukopenia, and thrombocytopenia. The number of cycle chemotherapy use carboplatin paclitaxel regiments affects significant with the incidence of anemia. Patients who use paclitaxel-carboplatin as a regimen chemotherapy confirmed decrease in hematologic data such as hemoglobin, leukocyte, and thrombocyte.

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Journal Info

Abbrev

JFSK

Publisher

Subject

Medicine & Pharmacology

Description

Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community / J Pharm Sci Community) firstly published in 2003, is a peer-reviewed, open access scientific journal that publishes research articles, review articles, as well as short communication in various pharmaceutical ...