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All Journal Jurnal Ilmu Pertanian Indonesia Indonesian Journal of Cancer Chemoprevention Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Jurnal Farmasi Sains dan Komunitas ALCHEMY Jurnal Penelitian Kimia JKPK (Jurnal Kimia dan Pendidikan Kimia)
Annisa Diyan Meitasari
Department Of Pharmacy, Vocational College, Universitas Sebelas Maret Surakarta, Central Java, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Environmental Science Materials Science & Nanotechnology Medicine & Pharmacology

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Faktor-Faktor yang Mempengaruhi Kepatuhan Pasien Hipertensi Pasien Rujuk Balik di Kimia Farma Ponorogo Annisa Diyan Meitasari
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 21, No 1 (2024): Jurnal Ilmu Farmasi & Farmasi Klinik
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v21i1.8248

Abstract

Hipertensi merupakan salah satu faktor risiko utama penyebab gangguan jantung. Selain mengakibatkan gagal jantung, hipertensi dapat juga berakibat terjadinya gagal ginjal maupun penyakit serebrovaskular. Kepatuhan minum obat bagi pasien penyakit kronis seperti hipertensi sangat penting karena dengan minum obat secara teratur dapat mengontrol tekanan darah pasien. Penelitian ini bertujuan untuk menganalisis faktor apa saja yang mempengaruhi kepatuhan minum obat pasien hipertensi program rujuk balik BPJS di Apotek Kimia Farma Ponorogo. Jenis penelitian ini adalah penelitian observasional (non eksperimental) dengan pendekatan deskriptif survei dengan teknik pengambilan sampel secara accidental sampling. Penelitian ini dilakukan di Apotek Kimia Farma Ponorogo pada bulan Maret 2022. Responden dari penelitian ini berjumlah 184 responden yang termasuk kriteria inklusi. Pengambilan data menggunakan kuesioner MMAS-8 (Morisky Medication Adherence Scale). Pengolahan data dilakukakan dengan pendekatan cross-sectional dengan metode Chi-square. Hasil analisis hubungan kepatuhan dengan beberapa faktor adalah jenis kelamin, usia, pendidikan, jenis pekerjaan, lama waktu menderita hipertensi, dan jumlah obat tidak memiliki hubungan signifikan terhadap tingkat kepatuhan minum obat pasien. Sedangkan untuk faktor tekanan darah memiliki hubungan signifikan terhadap kepatuhan minum obat dengan P-value 0,00 (p < 0,05).
HPLC Analysis with Evaluation of Antioxidant and Antisenescence Activities of Parijoto (Medinilla speciosa Reinw. ex Bl.) Methanolic Extract in Vero Cells Anif Nur Artanti; Sholichah Rohmani; Diyah Tri Utami; Nindita Clourisa Amaris Susanto; M. Fiqri Zulpadly; Annisa Diyan Meitasari; Ulfa Afrinurfadhilah Darojati; Meta Kartika Untari; Heru Sasongko; Dian Eka Ermawati; Feri Setyawan
Indonesian Journal of Cancer Chemoprevention Vol 16, No 1 (2025)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev16iss1pp44-56

Abstract

Parijoto (Medinilla speciosa Reinw. ex Bl.) is a traditional medicinal plant rich in polyphenolic compounds that are associated with antioxidant and cytoprotective activities. The present study aims to investigate the phytochemical profile, antioxidant capacity, cytotoxicity, and anti-senescence effects of parijoto methanolic extract. The methanolic extract of parijoto (MEP) was subjected to qualitative thin-layer chromatography (TLC) for the detection of flavonoids, quantitative high-performance liquid chromatography (HPLC) for the determination of quercetin and naringin, and antioxidant activity assessment using the DPPH method. The mobile phase for quercetin analysis was water: acetonitrile (45:55), while for naringin, it was acetonitrile:water: formic acid (21:78.8:0.2). Cytotoxicity was evaluated in Vero cells using the MTT assay, while senescence in normal kidney cells was assessed by senescence-associated β-galactosidase (SA-β-gal) staining. Results showed that the extract contained quercetin (5.76±0.11 ppm). The extract exhibited strong antioxidant activity with an IC₅₀ value of 40.46 ppm. Cytotoxicity testing of MEP on Vero cells revealed low toxicity (529±0.77 μM) at physiologically relevant concentrations, supporting its safety for normal kidney cells. Moreover, in normal kidney cells, the extract conferred cytoprotective effects by reducing oxidative stress–induced damage and attenuating senescence-associated β-galactosidase. Collectively, these findings suggest that MEP exhibits potent antioxidant, cytoprotective, and anti-senescence activity in vitro, warranting further in vivo studies to validate its potential effects on kidney health and age-related cellular damage.
Antibiofilm Activity of Ethanolic Extract of Zingiber officinale against Aggregatibacter actinomycetemcomitans ATCC 43718 (serotype B) Putri Cahaya Situmorang; Dian Eka Ermawati; Nindita Clourisa Amaris Susanto; Diyah Tri Utami; Heru Sasongko; Sholichah Rohmani; M Fiqri Zulpadly; Anif Nur Artanti; Ulfa Afrinurfadhilah Darojati; Annisa Diyan Meitasari; Meta Kartika Untari
Jurnal Ilmu Pertanian Indonesia Vol. 31 No. 3 (2026): Jurnal Ilmu Pertanian Indonesia
Publisher : Institut Pertanian Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18343/jipi.31.3.435

Abstract

Red ginger plays a role in bacterial infection, diarrhea, and cough. Therefore, this study aims to evaluate the ethanolic extract of Zingiber officinale for its antibiofilm activity against Aggregatibacter actinomycetemcomitans ATCC 43718 (serotype B). The extraction process of Zingiber officinale is carried out by maceration.  An antibiofilm activity assay was used with the dilution method with the various formulas of 20;10;5;2,5;1,25 % w/v. The biofilm inhibition concentration (MBIC50) was calculated. The SEM analysis was conducted to evaluate biofilm bacterial growth after the treatment. The data was then analyzed with IBM SPSS Statistics version 21.0 using one-way ANOVA (Analysis of Variance). The results showed that the ethanolic extract of Zingiber officinale had an inhibitory effect on A. actinomycetemcomitans ATCC 43718 (serotype B). This proved that the biofilm bacterial growth was effectively inhibited by the chemical compound of red ginger. The extracellular polymeric substance (EPS) matrix degraded after treating the cell biofilm. It can be concluded that the ethanolic extract of Zingiber officinale has potential against A. actinomycetemcomitans. Further research is needed to determine the safety and efficacy of A. actinomycetemcomitans ATCC 43718 (serotype B) can be developed as an alternative antibiofilm  
The Effect of Co-Processed Excipient and Mannitol on Physical Properties and Release Test of Flavonoid Total of Bajakah Root (Spatholobus littoralis Hassk.) Water Extract in Effervescent Granule Dian Eka Ermawati; Nur Cahyo Fajar Trihantono; Ulfa Afrinurfadhilah Darojati; Nindita Claurisa Amaris Susanto; Sholichah Rohmani; M. Fiqri Zulpadly; Annisa Diyan Meitasari; Diyah Tri Utami; Anif Nur Artanti; Heru Sasongko; Meta Kartika Untari
ALCHEMY Jurnal Penelitian Kimia Vol 22, No 1 (2026): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.22.1.94157.148-156

Abstract

Bajakah root is traditionally used in herbal medicine and exhibits notable antioxidant activity (IC₅₀ = 0.155 mg/mL) with a total flavonoid content of 32.49 ppm. However, conventional consumption by boiling is limited by poor taste, odor, and low stability. To overcome these limitations, this study developed effervescent granules to enhance acceptability and absorption. The effect of combining co-processed excipients (lactose–manihot starch in a ratio of 64.32:35.68) with mannitol on granule characteristics and flavonoid release was investigated. Bajakah root extract was prepared by hot water infusion (90 °C, 15 min; ratios 1:10 and 1:20) followed by freeze-drying. Phytochemical contents were analyzed using UV–Vis spectrophotometry. Co-processed excipients were prepared via wet granulation and characterized by SEM. Formulations with co-processed excipient–mannitol ratios of 3:1, 2:2, and 1:3 were evaluated for physicochemical properties and flavonoid release. Results showed total flavonoid and tannin contents in the extract of 2.19% and 9.04%, respectively. Excipient ratios significantly affected flow rate, angle of repose, moisture content, and disintegration time (p &lt; 0.05), but not pH. All formulations met pharmacopoeial requirements for ≥80% flavonoid release within 60 min. The optimal formulation (1:3) demonstrated excellent properties, supporting its potential as an effective herbal delivery system.
Hematology Toxicities in Paclitaxel-Carboplatin Cancer Regiment Annisa Diyan Meitasari; Dian Eka Ermawati; Sholichah Rohmani; Heru Sasongko; Muhammad Fiqri Zulpadly; Diyah Tri Utami; Nindita Clourisa Amaris Susanto; Meta Kartika Untari; Ulfa Afrinurfadhilah Darojati
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 1 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.007064

Abstract

Chemotherapy is one of therapy for patients with cancer. Treatment carboplatin paclitaxel regimen is usually use for cervix, breast, and ovarium cancer. But the data of ADRs in hematology toxicity caused paclitaxel-carboplatin regiment is minimal, so it is required to do research. The aim of this research is can give information about the hematology toxicity, incident, severity, relationship between risk factor due incident of myelosuppression, and relationship between pre post chemotherapy due the myelosuppression. The severity ADRs use CTCAE 5.0. The ADRs were evaluated by severity, descriptive statistics, and some bivariate analysis. Anemia (66.46%) has a highest incident and followed by leukopenia (18.18%), neutropenia (13.22%), and thrombocytopenia (9.09%). Type of cancer associate with incident of anemia, leukopenia, and thrombocytopenia. The number of cycle chemotherapy use carboplatin paclitaxel regiments affects significant with the incidence of anemia. Patients who use paclitaxel-carboplatin as a regimen chemotherapy confirmed decrease in hematologic data such as hemoglobin, leukocyte, and thrombocyte.
The Effect of Variation Concentration of Simplex Syrup on the Physicochemical Stability of Nanosilver Syrup Dian Eka Ermawati; Yavi Hanuriansyah; Nindita Clourisa Amaris Susanto; Sholichah Rochmani; Diyah Tri Utami; M. Fiqri Zulpadly; Heru Sasongko; Ulfa Afrinurfadhilah Darojati; Annisa Diyan Meitasari; Meta Kartika Untari
JKPK (Jurnal Kimia dan Pendidikan Kimia) Vol 9, No 2 (2024): JKPK (Jurnal Kimia dan Pendidikan Kimia)
Publisher : Program Studi Pendidikan Kimia FKIP Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jkpk.v9i2.84012

Abstract

Inulin from Gembili has been identified as an effective bioreductor for forming nanosilver with a size of 481.4 nm, stable for 30 days when stored at 4°C. Inulin nanosilver exhibits immunomodulatory properties and has been proven safe through acute toxicity evaluation at a dose of 4 mg/kgBB. A drug delivery system needs to be developed for its use as a supplement. Syrup was chosen due to its alcohol-free nature, better taste, and ease of measuring the active substance compared to elixirs, solutions, and suspensions. Simplex syrupus, used as a syrup base, influences stability by potentially forming crystals during storage. This research aims to determine how varying concentrations of simplex syrupus affect the physicochemical properties of inulin nanosilver syrup. The study involved the biosynthesis process using Gembili's inulin, nanosilver characterization, formulation, and stability testing. Inulin nanosilver syrup was prepared with simplex syrupus concentrations of 20%, 40%, and 60%. The physicochemical stability of the syrup, including organoleptic properties, pH, and viscosity, was tested before and after storage at 4°C and 40°C over six cycles. The selected formula was evaluated for sugar reduction content and FT-IR profile. Data analysis was performed using SPSS 21.0 for Windows with One-way ANOVA and Paired T-Test. Results indicated that higher concentrations of simplex syrupus led to increased consistency, pH, and viscosity. A 60% concentration of simplex syrupus met the physicochemical stability requirements, with a medium-thick consistency, pH of 5.25±0.03, and viscosity of 92±2.6 cps. The reducing sugar content was 20.59% ±0.002, and the FT-IR profile confirmed the presence of inulin nanosilver, indicated by Ag-N groups compared to silver nitrate solution. This product has the potential to be developed as a health supplement.
Co-Authors Anif Nur Artanti Anif Nur Artanti Anif Nur Artanti Dian Eka Ermawati Dian Eka Ermawati Dian Eka Ermawati Dian Eka Ermawati Diyah Tri Utami Diyah Tri Utami Diyah Tri Utami Diyah Tri Utami Feri Setyawan Heru Sasongko Heru Sasongko Heru Sasongko Heru Sasongko M Fiqri Zulpadly M. Fiqri Zulpadly M. Fiqri Zulpadly M. Fiqri Zulpadly Meta Kartika Untari Meta Kartika Untari Meta Kartika Untari Meta Kartika Untari Muhammad Fiqri Zulpadly Nindita Claurisa Amaris Susanto Nindita Clourisa Amaris Susanto Nindita Clourisa Amaris Susanto Nindita Clourisa Amaris Susanto Nindita Clourisa Amaris Susanto Nur Cahyo Fajar Trihantono Putri Cahaya Situmorang Sholichah Rochmani Sholichah Rohmani Sholichah Rohmani Sholichah Rohmani Ulfa Afrinurfadhilah Darojati Yavi Hanuriansyah