Jurnal Sains Materi Indonesia
Vol. 27 No. 1 (2025): Jurnal Sains dan Materi Indonesia

Quercetin Encapsulation on Chitosan-Pectin Membranes as a Drug Delivery and Its Release Kinetics

Hastuti, Budi (Unknown)
Hadi, Saptono (Unknown)
Nisriyah, Safarin (Unknown)
Martanisa, Mutiah (Unknown)
Kamari, Azlan (Unknown)



Article Info

Publish Date
31 Aug 2025

Abstract

Chitosan-pectin membranes are biodegradable polyelectrolyte complexes, derived from biomaterials, with good stability for drug delivery applications. This study investigates the potential of these membranes to encapsulate quercetin, a flavonoid known for its therapeutic properties but limited for its low solubility, poor bioavailability, and rapid elimination. The membranes were synthesized using a 1:1 (w/w) chitosan-to-pectin ratio and loaded with quercetin via solvent evaporation. Characterization using FTIR confirmed the presence of OH, C=O, and NH groups; XRD indicated semi-crystalline structure; and SEM revealed a uniform, porous morphology. The maximum quercetin loading efficiency reached 82.43%, with the highest release (90.39%) observed at pH 1.2, following first-order kinetics. The resulting membrane was thin, brown, homogeneous, and tear-resistant, demonstrating its potential as a controlled drug delivery matrix for quercetin

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Journal Info

Abbrev

jsmi

Publisher

Subject

Engineering Industrial & Manufacturing Engineering Materials Science & Nanotechnology

Description

Jurnal Sains Materi Indonesia (Indonesian Journal of Materials Science, JUSAMI) is an international peer-reviewed journal that publishes significant and important research from all areas of materials science and engineering. The topics discussed in JUSAMI are research & development results in ...