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All Journal Jurnal Inovasi Pendidikan IPA Jurnal Sains Materi Indonesia
Martanisa, Mutiah
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Agriculture, Biological Sciences & Forestry Education Engineering Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mathematics

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Quercetin Encapsulation on Chitosan-Pectin Membranes as a Drug Delivery and Its Release Kinetics Hastuti, Budi; Hadi, Saptono; Nisriyah, Safarin; Martanisa, Mutiah; Kamari, Azlan
Jurnal Sains Materi Indonesia Vol. 27 No. 1 (2025): Jurnal Sains dan Materi Indonesia
Publisher : BRIN Publishing (Penerbit BRIN)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jsmi.2025.9988

Abstract

Chitosan-pectin membranes are biodegradable polyelectrolyte complexes, derived from biomaterials, with good stability for drug delivery applications. This study investigates the potential of these membranes to encapsulate quercetin, a flavonoid known for its therapeutic properties but limited for its low solubility, poor bioavailability, and rapid elimination. The membranes were synthesized using a 1:1 (w/w) chitosan-to-pectin ratio and loaded with quercetin via solvent evaporation. Characterization using FTIR confirmed the presence of OH, C=O, and NH groups; XRD indicated semi-crystalline structure; and SEM revealed a uniform, porous morphology. The maximum quercetin loading efficiency reached 82.43%, with the highest release (90.39%) observed at pH 1.2, following first-order kinetics. The resulting membrane was thin, brown, homogeneous, and tear-resistant, demonstrating its potential as a controlled drug delivery matrix for quercetin
Effectiveness of Discovery Learning Assisted by Chemical Monopoly on Critical Thinking and Learning Outcomes Martanisa, Mutiah; Hastuti, Budi; Setyowati, Widiastuti Agustina Eko; Kamari, Azlan
Jurnal Inovasi Pendidikan IPA Vol. 11 No. 2: October 2025
Publisher : Faculty of Mathematics and Natural Sciences, Universitas Negeri Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21831/jipi.v11i2.84674

Abstract

The purpose of this research is to determine the effect of the discovery learning model using chemistry monopoly media on the critical thinking skills and learning outcomes of 11th-grade students. This research employs a quantitative descriptive approach with a quasi-experimental design and a pretest-posttest nonequivalent control group design, utilizing instruments in the form of tests and an observation guide. The sampling technique used is cluster random sampling. Both the experimental class and the control class have 35 students. This study collected data through tests (pretest and posttest). Data analysis was conducted using normality and homogeneity tests, followed by the Mann-Whitney U test (since the data are not normally distributed), and the N-Gain test for assessing learning effectiveness. The research results indicate that the experimental class achieved a 58.79% increase in learning outcomes, whereas the control class experienced a 36.51% increase. In terms of critical thinking ability, the experimental class showed an improvement of 56.00%, while the control class improved by 37.18%. The Mann-Whitney U hypothesis test revealed the significance of cognitive learning outcomes to be 0.041 and the significance of critical thinking ability to be 0.019. Thus, the implementation of discovery learning affects students' critical thinking skills and learning outcomes in the context of acid-base chemistry
Co-Authors Budi Hastuti Kamari, Azlan Nisriyah, Safarin Saptono Hadi, Saptono Setyowati, Widiastuti Agustina Eko