<![CDATA[This study aims to determine the effect of Roselle flower extract (Hibiscus sabdariffa L.) on cholesterol levels in White Rats (Rattus norvegicus) induced by LDL. The research method used is a Laboratory experimental method with a Completely Randomized Design (CRD) pattern. The number of samples used was 24 White Rats consisting of 6 treatment groups and 4 replications. The normal control group (KN) is a group that is only given food and drink, the negative control group (K-) is given LDL induction for 30 days, the positive control group (K+) is given LDL induction for 30 days and simvastatin, groups PI, PII and PIII are given LDL induction for 30 days and Roselle flower extract doses of 50 mg/kg BW, 100 mg/kg BW and 150 mg/kg BW for 21 days. The data obtained were tabulated and analyzed by the one-way ANOVA statistical test using SPSS version-30. The results showed that Roselle flower extract positively contains bioactive compounds such as flavonoids and tannins and has a significant effect (p<0.05) on reducing cholesterol levels in White Rats induced by LDL. The effective dose to reduce cholesterol levels is a dose of 100 mg/kg BW and 150 mg/kg BW.]]>
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