<![CDATA[Background: Indonesia has natural wealth in the form of plants that can provide benefits to humans in terms of medicine and health, one of which is papaya leaves. This plant has many health benefits, such as being a source of nutrients, antioxidants, helping maintain a healthy digestive tract, managing diabetes, helping reduce inflammation, and helping skin health. Papaya leaves have been identified to contain alkaloids, flavonoids, tannins, saponins and steroids/triterpenoids. Pharmacognostic studies are a systematic process of investigating, studying, and analyzing a topic, problem, or phenomenon using scientific methods or a structured approach.Objective: This research aims to understand the physical, chemical and pharmacological properties of papaya leaf simplicia.Methods: This type of research is experimental research, in testing papaya leaves extracts were made using the maceration method.Results: The analysis results showed that the drying loss of papaya leaf samples was -63.04%, in accordance with herbal pharmacopoeia standards which require drying loss ≤ 10%. Meanwhile, the water soluble extract content test produced a value of 21.976%, while the ethanol soluble extract content test showed a value of 21.872%. The results of the non-specific parameter test showed that the total ash content of papaya leaves was 11.025%, while the acid insoluble ash content was 0.82%. Conclusion: The maceration extraction method with 96% ethanol solvent was proven to be effective in extracting these compounds from papaya leaves.]]>
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