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Potensi Antimikroba Ekstrak Etanol Kulit Luar Buah Cempedak (Artocarpus integer (Thunb.) Merr.) Rina Saputri; Ali Rakhman Hakim; Dahlia Syahrina; Fatthiya Lisyanti
Jurnal Surya Medika (JSM) Vol 5 No 1 (2019): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (440.188 KB) | DOI: 10.33084/jsm.v5i1.945

Abstract

The background of this research is to develop the potential of biological resources in South Kalimantan. In particular, the biological source is cempedak fruit. The use of cempedak which has been scientifically studied is the use of cempedak bark as anti-malaria. Other studies related to other parts of cempedak are still not widely used. Based on the potential possessed by cempedak bark, it is likely that other parts of cempedak also have potential as traditional medicine. This study aims to identify the content of secondary metabolites from the outer skin of cempedak fruit, analyze the potential of the outer skin of cempedak fruit as an antimicrobial and analyze the effective dose as an antimicrobial. The method used to see MIC values with liquid dilution and KBM values with solid dilution. The results of phytochemical identification showed that the ethanol extract of the outer skin of cempedak fruit contained secondary metabolites in the form of saponins, tannins, flavonoids and alkaloids which have antimicrobial potential. The results of the antimicrobial activity test showed the MIC value of the ethanol extract of cempedak fruit outer skin against Escherichia coli bacteria at a concentration of 50% and against Staphylococcus aureus at a concentration of 25%. The KBM value also shows the same value as KHM. Based on the results of the study it can be concluded that the ethanol extract of cempedak fruit outer skin has broad-spectrum antimicrobial activity.
Narrative Review: Optimasi Etanol sebagai Pelarut Senyawa Flavonoid dan Fenolik Ali Rakhman Hakim; Rina Saputri
Jurnal Surya Medika (JSM) Vol 6 No 1 (2020): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v6i1.1641

Abstract

The use of ethanol as a solvent for secondary metabolite compounds is very widespread. Ethanol can dissolve flavonoid compounds and phenolic compounds from plants. To be able to utilize ethanol as a solvent is dependent on some factors of concentration, temperature, time, and selection of extraction methods. This study uses the method by searching scientific articles from the MDPI website database. The Ultrasound-Assisted Extraction (UAE) method is very suitable for the optimization of ethanol as a solvent. The optimal use of ethanol is in the concentration range of 50-80%, temperature conditions in the range of 40-70ºC, and the extraction time is in the range of 30 minutes - 24 hours.
Narrative Review: Implementasi Distribusi Obat yang Baik di Pedagang Besar Farmasi Mustaqimah Mustaqimah; Rina Saputri; Ali Rakhman Hakim
Jurnal Surya Medika (JSM) Vol 6 No 2 (2021): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v6i2.2128

Abstract

Distribution of pharmaceutical products from the pharmaceutical industry before reaching the pharmacy service point must be through wholesale. Good distribution practice methods are a set of standardized routine working methods, which ensure the quality, safety, and efficacy of pharmaceutical products remain intact from the very beginning to the end of the expiration period. Good distribution practice methods must be implemented by all wholesale in Indonesia so that wholesale operations can run effectively and efficiently. All pharmaceutical wholesalers must have standard operating procedures, personnel with integrity, and a good documentation system.
Analisis Faktor yang Berhubungan dengan Kepatuhan Pasien di Kabupaten Banjar Mustaqimah Mustaqimah; Rina Saputri; Ali Rakhman Hakim; Reny Indriyani
Jurnal Surya Medika (JSM) Vol 7 No 1 (2021): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v7i1.2659

Abstract

Hypertension is still the most common disease in the world. South Kalimantan Province in 2018 became the province with the highest number of hypertension sufferers in Indonesia. Hypertensive patients will undergo hypertension therapy for the rest of their lives so that blood pressure can still be well controlled. Lifelong therapy can reduce patient compliance in taking hypertension drugs; this can result in failed therapeutic goals and lead to the emergence of other diseases such as myocardial infarction and others. The purpose of this study was to analyze sociodemographic factors and clinical factors that may be related to patient compliance in taking hypertension drugs in Banjar Regency. The results showed that the majority of respondents had low compliance in consuming hypertension drugs. The analysis showed that sociodemographic factors such as gender, age, occupation, and place of getting the drug and clinical factors in the form of drugs used and blood pressure control did not show a significant relationship. The education factor shows a p-value < 0.05, which indicates the education factor has a significant relationship.
Analisis Toksisitas Akut Kombinasi Captopril dengan Rebusan Daun Sirsak pada Tikus Galur Wistar Rina Saputri; Mustaqimah Mustaqimah; Ali Rakhman Hakim
Jurnal Surya Medika (JSM) Vol 7 No 2 (2022): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v7i2.2849

Abstract

Hypertension is a degenerative disease that requires lifelong therapy. Along with the development of time, nowadays people are more interested in consuming traditional medicine, especially by using plants. In addition to consuming soursop leaf decoction, people also continue to use conventional medicine to help control hypertension. The combination of conventional medicine and traditional medicine can cause unwanted reactions if not used in the right dosage, one of which is the risk of acute toxicity. Until now there is no published data showing the acute toxicity analysis of the combination of captopril with soursop leaf decoction. The purpose of the study was to determine the maximum dose of the combination of captopril and soursop leaf decoction that could be used. The method used in this study is an advanced experimental study with a random block design using 30 test animals divided into 10 groups. The results of the acute toxicity test conducted did not show any death of the test animals within 24 hours and up to 7 days of observation in all experimental groups. The results of the physical observation test for 7 days showed that all rats were in normal condition in all experimental groups. The conclusion of this study is that the combination of captopril up to a dose of 150 mg/day (dose in humans before conversion to test animals) + soursop leaf decoction with an effective dose of 300 ml (dose in humans before conversion to test animals) did not show any death and symptoms toxicity in test animals.
Aktivitas Antioksidan Kulit Buah Cempedak (Artocarpus integer (Thunb.) Merr.) asal Kalimantan Selatan Ali Rakhman Hakim; Rina Saputri; Amanda Shelvia Savitri; Anisa Ujuldah; Fitri Sadlia
Jurnal Surya Medika (JSM) Vol 7 No 2 (2022): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v7i2.2858

Abstract

The increasing incidence of diseases related to oxidative stress among the human population has led to an increase in the consumption of natural antioxidants in the human diet. The purpose of this study was to determine the antioxidant activity of cempedak fruit skin extract with 50% ethanol and 70% ethanol as solvents. The method used was testing of radical inhibitory activity with the DPPH method (1,1-diphenyl-picrylhydrazil) and as a positive control was vitamin C. The results of phytochemical screening were known to contain phenolics, flavonoids, and tannins. The results of the antioxidant activity of E50% obtained IC50 values of 650.07 ppm and IC50 of E70 of 1219.69 ppm. From these results, it can be concluded that the skin of the cempedak fruit does not have antioxidant activity.
HUBUNGAN PENGETAHUAN DENGAN SIKAP IBU HAMIL TENTANG KELAS IBU HAMIL DI DESA KERTAK HANYAR II WILAYAH PUSKESMAS KERTAK HANYAR KABUPATEN BANJAR TAHUN 2016 Dede Mahdiyah; Ali Rakhman Hakim; Endang Susilawati
DINAMIKA KESEHATAN: JURNAL KEBIDANAN DAN KEPERAWATAN Vol 8, No 1 (2017): DINAMIKA KESEHATAN JURNAL KEBIDANAN DAN KEPERAWATAN
Publisher : Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (240.784 KB)

Abstract

Latar Belakang : Angka Kematian Bayi (AKB) dan Angka Kematian Ibu (AKI) di Indonesia masih cukup tinggi dibandingkan dengan negara ASEAN lainya. Untuk menurunkan Angka Kematian Ibu harus mensinergiskan beberapa program yang terkait mulai dari sejak saat Ibu hamil, melahirkan, bayi, balita, remaja, PUS sampai Usia lanjut. Salah satu upaya memperkenalkan dan meningkatkan pemahaman ibu hamil tentang buku KIA adalah dengan melaksanakan kelas ibu hamil. Kelas ibu hamil merupakan kegiatan yang sangat bermanfaat bagi ibu, karena dapat menigkatkan pengetahuannya mengenai masalah kehamilannya. Pengetahuan dan sikap terhadap apa yang dilakukan merupakan faktor- faktor yang dapat mempermudah atau mempredisposisi terjadinya prilaku pada diri sendiri seseorang namun suatu sikap belum otomatis terwujudnya dalam suatu tindakan.Tujuan : Untuk menganalisis hubungan antara pengetahuan dengan sikap ibu hamil tentang kelas ibu hamil di Desa Kertak Hanyar II wilayah puskesmas Kertak Hanyar Kabupaten Banjar.Metode : Metode penelitian ini menggunakan survei Analitik dengan jenis penelitian observasional serta menggunakan desain studi atau rancangan cross sectional. Populasi pada penelitian ini adalah semua Ibu hamil bulan Maret tahun 2016 di desa Kertak Hanyar II Puskesmas Kertak Hanyar Kabupaten Banjar yang berjumlah 101 orang. Jumlah sampel 50 responden. Teknik sampling menggunakan simple random sampling. Pengumpulan data menggunakan kuesioner. Analisis dengan uji chi square (α= 0,05)Hasil : Ibu dengan pengetahuan baik tentang kelas ibu hamil sebanyak 36 orang (72,0%) dan ibu dengan sikap positif (mendukung) tentang kelas ibu hamil sebanyak 37 orang (74,0%) didesa Kertak Hanyar II di puskesmas Kertak. Berdasarkan uji chi square didapat nilai p=0,804 α=0,05Simpulan : Tidak ada hubungan pengetahuan dengan sikap ibu hamil tentang kelas ibu hamil wilayah II Kertak Hanyar Kabupaten BanjarKata Kunci : Kelas Ibu Hamil, Pengetahuan, Sikap.
Analisis Kadar Tanin Ekstrak Etanol Kulit Batang Kemiri (Aleurites moluccana (L.) Willd) dengan Metode Titrimetri Sofiya Maulida; Ali Rakhman Hakim; M. Sobirin Mohtar
Jurnal Pelayanan Kefarmasian dan Sains Vol 1 No 1 (2020): Journal Of Pharmaceutical Care and Science
Publisher : LPPM Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (332.559 KB)

Abstract

Introduction: Plants have a great potential to be used as traditional medicine, so it is necessary to standardize realated compounds responsible for pharmacological activities or secondary metabolite compounds of a plant. One of medicinal plants is candlenut, this is plant has many uses in almost all parts of the plant. Candlenut stem bark has been used as traditional medicine by the community in Muara Langon village, Paser district, East Kalimantan to treat hypercholesterolemia. Objective: To know the candlenut stem bark ethanol extract containing flavonoid, saponin, tannin compounds and knowing the levels of tannin compounds contained in the sample. Methods: Extraction was carried out by maceration method. Qualitative analysis was carried out by phytochemical screening tests for flavonoid, saponin and tannin compounds by the tube method. Quantitative analysis was carried out by determining the levels of tannin compounds using the titrimetry method by permanganometric titration. Results: The extraction of 500 grams candlenut stem bark and 4 liters ethanol 70% sovent obtained was the extract rate od 4,022%. The results of the qualitative analysis by phytochemical sreening test showed that the candlenut stem bark ethanol extract is positively contained flavonoid, saponin and tanin compounds. The result of quantitative analysis with titrimetry method obtained levels of tannin compounds in the candlenut stem bark ethanol extract is 5,40598 %. Conclusion: The candlenut stem bark ethanol extract contained flavonoid, saponin and tanin compounds and tannin compound levels is 5,40598 %. Keywords: Candlenut stem bark, Tannin levels, Titrimetry.
Aktivitas Antioksidan Dari Infusa Kelakai (Stenochlaena palustris (Burm.F) Bedd) Ali Rakhman Hakim; Amanda Shelvia Savitri; Rina Saputri
Jurnal Pelayanan Kefarmasian dan Sains Vol 1 No 2 (2021): Journal Pharmaceutical Care and Sciences
Publisher : LPPM Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (311.806 KB) | DOI: 10.33859/jpcs.v2i1.69

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Background: Kelakai (Stenochlaena palustris (Burn. F) Bedd.) Is a plant originating from Kalimantan that grows on peat soil. Objective: to determine the antioxidant activity of the leaves of kelakai (Stenochlaena palustris (Burm. F) Bedd.) made by infusion. Method: This type of research is true experimental and research method with post test only control group design. Kelakai made an infusion and then tested for antioxidant activity using the DPPH method. Results: The kelakai infusion positive contains flavonoids. Kelakai infusion has a very strong antioxidant activity at a concentration of 20 ppm with an absorbance value of 0.072 and an antioxidant activity of 86.90%. Kelakai infusion has an IC50 value of 6.4035 ppm. Conclusion: kelakai infusion positive contains flavonoid compounds and has a very strong antioxidant ability with an IC50 value of 6.4035 ppm. Keywords: antioxidants, flavonoids, infusion, kelakai
Profil Penggunaan Antibiotika di Puskesmas Hantakan dan Profil DAGUSIBU Antibiotika di Desa Hantakan dan Desa Alat Rina Saputri; Ali Rakhman Hakim
Jurnal Pelayanan Kefarmasian dan Sains Vol 1 No 2 (2021): Journal Pharmaceutical Care and Sciences
Publisher : LPPM Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (286.132 KB) | DOI: 10.33859/jpcs.v2i1.71

Abstract

Background : The used of antibiotics in Indonesia continues to increase, but not accompanied by good knowledge regarding the used of these antibiotics so that they have a high risk of causing antibiotic resistance. Objective : Knowing the profile of the use of Antibiotics in Puskesmas Hantakan and knowing the profile of DAGUSIBU antibiotics in Hantakan and Alat Villages. Method : This type of research is descriptive research with survey methods for the last 5 months from October 2020 to February 2021. The survey was also carried out directly to the respondents of the Hantakan Village RT.01 - RT.06 and in Village Alat RT.01 - RT.04. Results : The used of antibiotics at Puskesmas Hantakan is one of the top 10 drugs that are often prescribed. The type of antibiotic that is most widely prescribed is Amoxicillin. DAGUSIBU's profile on respondents shows that the majority of respondents get antibiotics from stalls, use antibiotics to treat various diseases, take antibiotics not according to intervals, stop antibiotics if they feel that conditions have improved, and still keep antibiotics in stock and dispose of antibiotics in an inappropriate way. Conclusion : Amoxicillin is a type of antibiotic that is most widely prescribed in Puskesmas Hantakan. The use of antibiotics without a doctor's prescription in Hantakan and Alat Villages is still high. The proper management of antibiotics among respondents in the Village of Hantakan and Alat was still low.
Co-Authors AA Sudharmawan, AA Adriana Palimbo, Adriana Agenia Rahman Agustin, Nur Syafa Ahmad Hidayat Ahmad Syahlani Ahnafani, Miyada Nur Aima Pitriya amanah, nurul Amanda Shelvia Savitri Amanda Shelvia Savitri Amanda Shelvia Savitri Amanda Shelvia Savitri Amanda, Era Dea Anggia Puteri Anisa Ujuldah Anisa Ujuldah Annisa Fitria Ariani, Malisa Aryzki, Saftia Asi, Seva Bela N. Asi, Seva Bela Nata Asti Wulan Ariani Auli Damayanti Aulia Damayanti Aulia Rahmah Aulia, Nina AYU LESTARI Azhimia, Faida Bayu Hari Mukti Budi, Seria Carolin, Putri Dahlia Syahrina Dede Mahdiyah Dede Mahdiyah, Dede Defitamira, Olvi Deviani, Norma Dian Bardiansyah Donaretsi, Olga Nathania Dwi Salmarini, Desilestia Elieser, Michael Endang Susilawati Enzelia, Yoan Esti Susilowati Evana, Nur Qomara Fadhiyah Noor Anisa Fahriani, Fahriani Fatthiya Lisyanti Faulina, Siti Emi Az-Zahra Fitri Sadlia Fitri Yuliana Fitri Yuliana, Fitri Fitriani, Dyah Fitriyana, Rahma Furqan, Rizqi Nur Giopani, Dea Lailani Gresia, Sola Gumarus, Ellora Griselda Habibah, Nor Hariyanto, Ario Yudo Hastika, Febby Yulia Heny Novarita Hepriana, Yemima Holilah, Shafira Nor Husna, Hafizatul I Ketut Purnama Putra Ihyadin, Hafiz Ikeh, Tri Sulapmi D. Ilahiya, Salwa Nur Indriyani, Reni Irpiana, Irma Ismiadi, Rahmad Jannah, Ghina Raudhatul Jesika Claudia Johanda, Maulida Julianti, Army Karina, Diah Karinda, Niken Adkah Khaliza Natasya Dilla Khatimah, Indah Husnul Komaliya, Risyda Kornelia, Sindi Kunti Nastiti Kurniawati, Darini Kusuma D, Muhammad Chandra Hadi L. Lisnawati Laetare, Tresy Patricia Laurensia Yunita Lestari, Noor Laili Mega Lestari, Yayuk Puji Linda Kusumawati Lisaura, Inggrit Windy M. Sobirin Mohtar Maharani, Silvia Atwi Maharani, Tri Anita Mahdalena Mahdalena Martha, Dhea Yolanda Marwah, Jannatul Maskura, Nur Maulani, Eka Febrianti Maulina, Nor Ma’rifah, Nurul Melviani, Melviani Mia Audina Mia Audina, Mia Miftahul Jannah Mohammad Basit, Mohammad Muhammad Aldi, Muhammad Muhammad Naufal, Muhammad Mustaqimah Mustaqimah Muzdalifah, Nur Nabila, Putri Nasiroh Nasiroh, Nasiroh Nastiti, Kunti Natantri, Bamikha Priskila Nayaken, Putri Olivia Ngongo, Marselina Nisa, Karimatun Nisrina, Salwa Nita Hestiyana nofrizal, deni Noor, Fadhiyah Noor Noorhaliza Noval Noval Noval Noval Noval Novalia Widiya Ningrum, Novalia Widiya Novalis, Rima Nugraha, Dyan Fitri Nur Hidayah NURUL HIDAYAH Oktavia, Regina Pebriana, Olvia Putri Pratiwi, Sinta Puji Lestari, Yayuk Puspa Indah Puteri Putri Vidiasari Darsono Putri Vidiasari Darsono, Putri Vidiasari Putri, Jelita Annisa Putri, Lidia Risma Putri, Mela Julia Rabiatul Adawiyah Rahayu, Desi Dwi Rahmadani Rahmadani Rahmadani Rahmadani Rahmah, Mulia Rahman, Agenia Ramadhan, Ahmad Dian Ramadhan, Novalina Rossa Ramadhani, Alya Raudhatul Jannah, Ghina Reny Indriyani Ria Fitriani Rina Saputri Rizali, Muhammad Rohama , Rohama Rohama, Rohama Rohama, Rohma Romika, Romika Rubina, Miranda Rustiana Rustiana Sadlia, Fitri Sagita, Ririn Samara, Akhmad Fadhil Saniah, Husnus Sari, Nita Wulan Sari, Rani Normaya Satria, Romi Savitri, Amanda Shelvia Setia Budi Sihotang, Ina Yunita Siswahyudianto Siti Azizah Siti Fatimah Siti Jubaidah, Siti Siti Malahayati Siti Sarah, Siti Sitti Khadijah Sofiya Maulida Sudarya, Maharani Fitria Syari, Aulia Rahma Syifa Khairunnisa syifa, Nur Syifa, Umi Tambun, Madschen Sia Mei Ol Siska Selvija Tuti Alawiyah Tuti Alawiyah Tuti Alawiyah Ujuldah, Anisa Ulfah, Annisa Ulpah, Nor Sipa Aulia Utami, Putri Nadila Vania, Risma Ananda Weliyanto, Yupi Winda, Nadia Oktavia Wineiniati, Noni Wulandari, Suci Sri Yanti, Novita Yasnatasya Ys, Jian Yuditha Mutia Windy Yuli Yanti Sholehah Yulida, Yulida Yustian, Alifira Adhany Yuwindry, Iwan Zhafirah, Nurul Zulianur, Riska Ali Zulliati Zulliati