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Potensi Antimikroba Ekstrak Etanol Kulit Luar Buah Cempedak (Artocarpus integer (Thunb.) Merr.) Rina Saputri; Ali Rakhman Hakim; Dahlia Syahrina; Fatthiya Lisyanti
Jurnal Surya Medika (JSM) Vol 5 No 1 (2019): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (440.188 KB) | DOI: 10.33084/jsm.v5i1.945

Abstract

The background of this research is to develop the potential of biological resources in South Kalimantan. In particular, the biological source is cempedak fruit. The use of cempedak which has been scientifically studied is the use of cempedak bark as anti-malaria. Other studies related to other parts of cempedak are still not widely used. Based on the potential possessed by cempedak bark, it is likely that other parts of cempedak also have potential as traditional medicine. This study aims to identify the content of secondary metabolites from the outer skin of cempedak fruit, analyze the potential of the outer skin of cempedak fruit as an antimicrobial and analyze the effective dose as an antimicrobial. The method used to see MIC values with liquid dilution and KBM values with solid dilution. The results of phytochemical identification showed that the ethanol extract of the outer skin of cempedak fruit contained secondary metabolites in the form of saponins, tannins, flavonoids and alkaloids which have antimicrobial potential. The results of the antimicrobial activity test showed the MIC value of the ethanol extract of cempedak fruit outer skin against Escherichia coli bacteria at a concentration of 50% and against Staphylococcus aureus at a concentration of 25%. The KBM value also shows the same value as KHM. Based on the results of the study it can be concluded that the ethanol extract of cempedak fruit outer skin has broad-spectrum antimicrobial activity.
Narrative Review: Optimasi Etanol sebagai Pelarut Senyawa Flavonoid dan Fenolik Ali Rakhman Hakim; Rina Saputri
Jurnal Surya Medika (JSM) Vol 6 No 1 (2020): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v6i1.1641

Abstract

The use of ethanol as a solvent for secondary metabolite compounds is very widespread. Ethanol can dissolve flavonoid compounds and phenolic compounds from plants. To be able to utilize ethanol as a solvent is dependent on some factors of concentration, temperature, time, and selection of extraction methods. This study uses the method by searching scientific articles from the MDPI website database. The Ultrasound-Assisted Extraction (UAE) method is very suitable for the optimization of ethanol as a solvent. The optimal use of ethanol is in the concentration range of 50-80%, temperature conditions in the range of 40-70ºC, and the extraction time is in the range of 30 minutes - 24 hours.
Narrative Review: Implementasi Distribusi Obat yang Baik di Pedagang Besar Farmasi Mustaqimah Mustaqimah; Rina Saputri; Ali Rakhman Hakim
Jurnal Surya Medika (JSM) Vol 6 No 2 (2021): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v6i2.2128

Abstract

Distribution of pharmaceutical products from the pharmaceutical industry before reaching the pharmacy service point must be through wholesale. Good distribution practice methods are a set of standardized routine working methods, which ensure the quality, safety, and efficacy of pharmaceutical products remain intact from the very beginning to the end of the expiration period. Good distribution practice methods must be implemented by all wholesale in Indonesia so that wholesale operations can run effectively and efficiently. All pharmaceutical wholesalers must have standard operating procedures, personnel with integrity, and a good documentation system.
Analisis Faktor yang Berhubungan dengan Kepatuhan Pasien di Kabupaten Banjar Mustaqimah Mustaqimah; Rina Saputri; Ali Rakhman Hakim; Reny Indriyani
Jurnal Surya Medika (JSM) Vol 7 No 1 (2021): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v7i1.2659

Abstract

Hypertension is still the most common disease in the world. South Kalimantan Province in 2018 became the province with the highest number of hypertension sufferers in Indonesia. Hypertensive patients will undergo hypertension therapy for the rest of their lives so that blood pressure can still be well controlled. Lifelong therapy can reduce patient compliance in taking hypertension drugs; this can result in failed therapeutic goals and lead to the emergence of other diseases such as myocardial infarction and others. The purpose of this study was to analyze sociodemographic factors and clinical factors that may be related to patient compliance in taking hypertension drugs in Banjar Regency. The results showed that the majority of respondents had low compliance in consuming hypertension drugs. The analysis showed that sociodemographic factors such as gender, age, occupation, and place of getting the drug and clinical factors in the form of drugs used and blood pressure control did not show a significant relationship. The education factor shows a p-value < 0.05, which indicates the education factor has a significant relationship.
Analisis Toksisitas Akut Kombinasi Captopril dengan Rebusan Daun Sirsak pada Tikus Galur Wistar Rina Saputri; Mustaqimah Mustaqimah; Ali Rakhman Hakim
Jurnal Surya Medika (JSM) Vol 7 No 2 (2022): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v7i2.2849

Abstract

Hypertension is a degenerative disease that requires lifelong therapy. Along with the development of time, nowadays people are more interested in consuming traditional medicine, especially by using plants. In addition to consuming soursop leaf decoction, people also continue to use conventional medicine to help control hypertension. The combination of conventional medicine and traditional medicine can cause unwanted reactions if not used in the right dosage, one of which is the risk of acute toxicity. Until now there is no published data showing the acute toxicity analysis of the combination of captopril with soursop leaf decoction. The purpose of the study was to determine the maximum dose of the combination of captopril and soursop leaf decoction that could be used. The method used in this study is an advanced experimental study with a random block design using 30 test animals divided into 10 groups. The results of the acute toxicity test conducted did not show any death of the test animals within 24 hours and up to 7 days of observation in all experimental groups. The results of the physical observation test for 7 days showed that all rats were in normal condition in all experimental groups. The conclusion of this study is that the combination of captopril up to a dose of 150 mg/day (dose in humans before conversion to test animals) + soursop leaf decoction with an effective dose of 300 ml (dose in humans before conversion to test animals) did not show any death and symptoms toxicity in test animals.
Aktivitas Antioksidan Kulit Buah Cempedak (Artocarpus integer (Thunb.) Merr.) asal Kalimantan Selatan Ali Rakhman Hakim; Rina Saputri; Amanda Shelvia Savitri; Anisa Ujuldah; Fitri Sadlia
Jurnal Surya Medika (JSM) Vol 7 No 2 (2022): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v7i2.2858

Abstract

The increasing incidence of diseases related to oxidative stress among the human population has led to an increase in the consumption of natural antioxidants in the human diet. The purpose of this study was to determine the antioxidant activity of cempedak fruit skin extract with 50% ethanol and 70% ethanol as solvents. The method used was testing of radical inhibitory activity with the DPPH method (1,1-diphenyl-picrylhydrazil) and as a positive control was vitamin C. The results of phytochemical screening were known to contain phenolics, flavonoids, and tannins. The results of the antioxidant activity of E50% obtained IC50 values of 650.07 ppm and IC50 of E70 of 1219.69 ppm. From these results, it can be concluded that the skin of the cempedak fruit does not have antioxidant activity.
Identifikasi Senyawa Kimia Ekstrak Etanol Mentimun (Cucumis sativus L.) dan Ekstrak Etanol Nanas (Ananas comosus (L) Merr.) Ali Rakhman Hakim; Rina Saputri
Jurnal Pharmascience Vol 4, No 1 (2017): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v4i1.5753

Abstract

ABSTRAK Bahan alam digunakan manusia sebagai obat untuk menyembuhkan, mencegah penyakit tertentu dan menjaga kondisi badan agar tetap sehat. Bahan alam yang digunakan dikenal dengan istilah obat herbal. Mentimun (Cucumis sativus L) dan Nanas (Ananas cosmosus (L) Merr) merupakan sebagian dari bahan alam yang dapat digunakan sebagai alternatif pengobatan. Penelitian ini bertujuan untuk mengidentifikasi kandungan senyawa kimia pada ekstrak etanol mentimun dan ekstrak etanol nanas yaitu senyawa saponin, steroid, terpenoid, tanin dan secara kualitatif. Ekstrak etanol mentimun dan ekstrak etanol nanas didapatkan dengan metode maserasi. Hasil identifikasi senyawa kimia menunjukan ekstrak etanol mentimun mengandung senyawa kimia terpenoid, saponin dan fenolik. Ekstrak etanol nanas mengandung terpenoid dan fenolik. Kata kunci: Identifikasi senyawa kimia, Mentimun (Cucumis sativus L), Nanas (Ananas cosmosus (L) Merr) ABSTRACT Natural materials has used by humans as a medicine to cure, prevent certain diseases and maintain body condition in order to stay healthy. Natural materials are used is known as herbal medicine. Cucumber (Cucumis sativus L) and Pineapple (Ananas cosmosus (L) Merr) is part of the natural materials that can be used as an alternative treatment. This study aims to identified the chemical compounds in extracts of cucumber ethanol and ethanol extract of pineapple there are saponins, steroids, terpenoids, tannins and qualitatively. The ethanol extract of cucumber and pineapple ethanol extracts obtained by maceration method. The results of the identification of chemical compounds showed the ethanol extract of cucumber contains chemical compounds terpenoids, saponins and phenolic. The ethanol extract of pineapple contains terpenoids and phenolic. Keywords: Identification of chemical compounds, cucumber (Cucumis sativus L), pineapple (Ananas comosus (L) Merr)
Analisis Toksisitas Akut Ekstrak Etanol Kulit Buah Cempedak pada Tikus Galur Wistar Ali Rakhman Hakim; Rina Saputri
Jurnal Pharmascience Vol 5, No 2 (2018): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v5i2.5799

Abstract

Kulit buah Cempedak yang digoreng (Manday) merupakan salah satu makanan yang umum dikonsumsi masyarakat di Kalimantan Selatan. Berdasarkan pengalaman dari beberapa masyarakat, keluhan yang sering terjadi adalah perut terasa perih dan kepala pusing. Evaluasi sifat toksik dari bagian tumbuhan yang dikonsumsi oleh masyarakat sangat penting untuk dilakukan dengan mempertimbangkan perlindungan kesehatan masyarakat karena paparan senyawa kimia dari bagian tumbuhan yang dapat menyebabkan efek yang tidak diinginkan pada masyarakat. Penelitian ini bertujuan untuk mengidentifikasi senyawa kimia dan efek toksisitas akut dari ekstrak etanol kulit buah cempedak. Kulit buah cempedak dikeringkan dengan menggunakan oven. Ekstraksi kulit buah cempedak menggunakan cara maserasi dengan cairan penyari etanol. Tikus uji diberi larutan kontrol Na CMC dan ekstrak dengan dosis 300 mg/kgBB, 1000 mg/kgBB, 2000 mg/kgBB, dan 5000 mg/kgBB. Hasil identifikasi senyawa kimia didapatkan positif mengandung triterpenoid, flavonoid, tanin, dan senyawa fenolik. Tikus uji yang menerima ekstrak dengan dosis 1000 mg/kgBB, 2000 mg/kgBB, dan 5000 mg/kgBB terjadi perubahan pada tikus uji berdasarkan pengamatan fisik yaitu mengalami peningkatan detak jantung atau takikardi, pernapasan cepat, tremor, dan agresif. Kata kunci: Kulit buah cempedak, senyawa kimia, toksisitas akut Rind of Cempedak fruit (Manday) is one of the foods commonly consumed by people in South Kalimantan. Based on the experience of several communities, complaints that often occur are sore stomach and headache. Evaluation of the toxic properties of plant parts consumed by the community is very important to be done by considering public health protection due to exposure to chemical compounds from parts of plants that can cause undesirable effects on the community. This study aims to identify chemical compounds and acute toxicity effects of ethanol extract rind of cempedak fruit. Rind of Cempedak fruit has dried using an oven. Extraction of cempedak fruit skin using maceration method with ethanol. Test rats were given Na CMC as a control and extract with dose 300 mg / kgBB, 1000 mg / kgBB, 2000 mg / kgBB, and 5000 mg / kgBB. The results of the identification of chemical compounds were obtained positively containing triterpenoids, flavonoids, tannins, and phenolic compounds. The test rats that received extracts at a dose of 1000 mg / kgBW, 2000 mg / kgBB, and 5000 mg / kgBW were changed in the test rats based on physical observations that experienced an increase in heart rate or tachycardia, rapid breathing, tremor, and aggressive. Keywords: acute toxicity, chemistry compounds, rind of cempedak fruit
HUBUNGAN PENGETAHUAN DENGAN SIKAP IBU HAMIL TENTANG KELAS IBU HAMIL DI DESA KERTAK HANYAR II WILAYAH PUSKESMAS KERTAK HANYAR KABUPATEN BANJAR TAHUN 2016 Dede Mahdiyah; Ali Rakhman Hakim; Endang Susilawati
DINAMIKA KESEHATAN: JURNAL KEBIDANAN DAN KEPERAWATAN Vol 8, No 1 (2017): DINAMIKA KESEHATAN JURNAL KEBIDANAN DAN KEPERAWATAN
Publisher : Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (240.784 KB)

Abstract

Latar Belakang : Angka Kematian Bayi (AKB) dan Angka Kematian Ibu (AKI) di Indonesia masih cukup tinggi dibandingkan dengan negara ASEAN lainya. Untuk menurunkan Angka Kematian Ibu harus mensinergiskan beberapa program yang terkait mulai dari sejak saat Ibu hamil, melahirkan, bayi, balita, remaja, PUS sampai Usia lanjut. Salah satu upaya memperkenalkan dan meningkatkan pemahaman ibu hamil tentang buku KIA adalah dengan melaksanakan kelas ibu hamil. Kelas ibu hamil merupakan kegiatan yang sangat bermanfaat bagi ibu, karena dapat menigkatkan pengetahuannya mengenai masalah kehamilannya. Pengetahuan dan sikap terhadap apa yang dilakukan merupakan faktor- faktor yang dapat mempermudah atau mempredisposisi terjadinya prilaku pada diri sendiri seseorang namun suatu sikap belum otomatis terwujudnya dalam suatu tindakan.Tujuan : Untuk menganalisis hubungan antara pengetahuan dengan sikap ibu hamil tentang kelas ibu hamil di Desa Kertak Hanyar II wilayah puskesmas Kertak Hanyar Kabupaten Banjar.Metode : Metode penelitian ini menggunakan survei Analitik dengan jenis penelitian observasional serta menggunakan desain studi atau rancangan cross sectional. Populasi pada penelitian ini adalah semua Ibu hamil bulan Maret tahun 2016 di desa Kertak Hanyar II Puskesmas Kertak Hanyar Kabupaten Banjar yang berjumlah 101 orang. Jumlah sampel 50 responden. Teknik sampling menggunakan simple random sampling. Pengumpulan data menggunakan kuesioner. Analisis dengan uji chi square (α= 0,05)Hasil : Ibu dengan pengetahuan baik tentang kelas ibu hamil sebanyak 36 orang (72,0%) dan ibu dengan sikap positif (mendukung) tentang kelas ibu hamil sebanyak 37 orang (74,0%) didesa Kertak Hanyar II di puskesmas Kertak. Berdasarkan uji chi square didapat nilai p=0,804 α=0,05Simpulan : Tidak ada hubungan pengetahuan dengan sikap ibu hamil tentang kelas ibu hamil wilayah II Kertak Hanyar Kabupaten BanjarKata Kunci : Kelas Ibu Hamil, Pengetahuan, Sikap.
Analisis Kadar Tanin Ekstrak Etanol Kulit Batang Kemiri (Aleurites moluccana (L.) Willd) dengan Metode Titrimetri Sofiya Maulida; Ali Rakhman Hakim; M. Sobirin Mohtar
Jurnal Pelayanan Kefarmasian dan Sains Vol 1 No 1 (2020): Journal Of Pharmaceutical Care and Science
Publisher : LPPM Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (332.559 KB)

Abstract

Introduction: Plants have a great potential to be used as traditional medicine, so it is necessary to standardize realated compounds responsible for pharmacological activities or secondary metabolite compounds of a plant. One of medicinal plants is candlenut, this is plant has many uses in almost all parts of the plant. Candlenut stem bark has been used as traditional medicine by the community in Muara Langon village, Paser district, East Kalimantan to treat hypercholesterolemia. Objective: To know the candlenut stem bark ethanol extract containing flavonoid, saponin, tannin compounds and knowing the levels of tannin compounds contained in the sample. Methods: Extraction was carried out by maceration method. Qualitative analysis was carried out by phytochemical screening tests for flavonoid, saponin and tannin compounds by the tube method. Quantitative analysis was carried out by determining the levels of tannin compounds using the titrimetry method by permanganometric titration. Results: The extraction of 500 grams candlenut stem bark and 4 liters ethanol 70% sovent obtained was the extract rate od 4,022%. The results of the qualitative analysis by phytochemical sreening test showed that the candlenut stem bark ethanol extract is positively contained flavonoid, saponin and tanin compounds. The result of quantitative analysis with titrimetry method obtained levels of tannin compounds in the candlenut stem bark ethanol extract is 5,40598 %. Conclusion: The candlenut stem bark ethanol extract contained flavonoid, saponin and tanin compounds and tannin compound levels is 5,40598 %. Keywords: Candlenut stem bark, Tannin levels, Titrimetry.
Co-Authors AA Sudharmawan, AA Adriana Palimbo, Adriana Agenia Rahman Agustin, Nur Syafa Ahmad Hidayat Ahmad Hidayat Ahmad Syahlani Ahnafani, Miyada Nur Aima Pitriya Alya Ramadhani amanah, nurul Amanda Shelvia Savitri Amanda Shelvia Savitri Amanda Shelvia Savitri Amanda Shelvia Savitri Anggia Puteri Anisa Ujuldah Anisa Ujuldah Annisa Fitria Ariani, Malisa Aryzki, Saftia Asi, Seva Bela N. Asi, Seva Bela Nata Asti Wulan Ariani Auli Damayanti Aulia Damayanti Aulia Rahmah Aulia, Nina AYU LESTARI Azhimia, Faida Bamikha Priskila Natantri Carolin, Putri Dahlia Syahrina Darini Kurniawati Dede Mahdiyah Dede Mahdiyah, Dede Defitamira, Olvi Desi Dwi Rahayu Deviani, Norma Dian Bardiansyah Diana Diana Donaretsi, Olga Nathania Dwi Salmarini, Desilestia Dyah Fitriani Endang Susilawati Enzelia, Yoan Esti Susilowati Evana, Nur Qomara Fadhiyah Noor Anisa Fahriani, Fahriani Fatthiya Lisyanti Faulina, Siti Emi Az-Zahra Fitri Sadlia Fitri Sadlia Fitri Yuliana Fitri Yuliana, Fitri Fitriyana, Rahma Ghina Raudhatul Jannah Giopani, Dea Lailani Gresia, Sola Gumarus, Ellora Griselda Habibah, Nor Hariyanto, Ario Yudo Heny Novarita Holilah, Shafira Nor I Ketut Purnama Putra Ikeh, Tri Sulapmi D. Indriyani, Reni Inggrit Windy Lisaura Jannah, Ghina Raudhatul Jesika Claudia Karina, Diah Karinda, Niken Adkah Khaliza Natasya Dilla Kornelia, Sindi Kunti Nastiti Kurniawati, Darini Kusuma D, Muhammad Chandra Hadi L. Lisnawati Laetare, Tresy Patricia Laurensia Yunita Lestari, Noor Laili Mega Lestari, Yayuk Puji M. Sobirin Mohtar Madschen Sia Mei Ol Siska Selvija Tambun Maharani Fitria Sudarya Maharani, Silvia Atwi Maharani, Tri Anita Mahdalena Mahdalena Malisa Ariani Martha, Dhea Yolanda Maskura, Nur Maulani, Eka Febrianti Ma’rifah, Nurul Mela Julia Putri Melviani, Melviani Mia Audina Mia Audina, Mia Michael Elieser Miftahul Jannah Miranda Rubina Mohammad Basit, Mohammad Muhammad Aldi, Muhammad Mustaqimah Mustaqimah Mustaqimah Mustaqimah Nabila, Putri Nasiroh Nasiroh, Nasiroh Nastiti, Kunti Natantri, Bamikha Priskila Nayaken, Putri Olivia Ngongo, Marselina Nisa, Karimatun Nisrina, Salwa Nita Hestiyana nofrizal, deni Noorhaliza Nor Habibah Noval Noval Noval Novalia Widiya Ningrum, Novalia Widiya Novalina Rossa Ramadhan Novalis, Rima Nur Hidayah Nur Muzdalifah Nurul Amanah NURUL HIDAYAH Nurul Hidayah Oktavia, Regina Pebriana, Olvia Putri Pratiwi, Sinta Puji Lestari, Yayuk Puteri Putri Vidiasari Darsono Putri Vidiasari Darsono, Putri Vidiasari Putri, Mela Julia Rabiatul Adawiyah Rahmadani Rahmadani Rahman, Agenia Ramadhan, Ahmad Dian Raudhatul Jannah, Ghina Reny Indriyani Ria Fitriani Rina Saputri Rina Saputri Rizali, Muhammad Rohama Rohama Rohama, Rohama Rubina, Miranda Rustiana Rustiana Sadlia, Fitri Saftia Aryzki Sagita, Ririn Samara, Akhmad Fadhil Saniah, Husnus Sari, Nita Wulan Sari, Rani Normaya Satria, Romi Savitri, Amanda Shelvia Setia Budi Shafira Nor Holilah Siti Azizah Siti Fatimah Siti Jubaidah, Siti Siti Malahayati Siti Sarah, Siti Sitti Khadijah Sofiya Maulida Syifa Khairunnisa syifa, Nur Syifa, Umi Tuti Alawiyah Tuti Alawiyah Ujuldah, Anisa Ulfah, Annisa Utami, Putri Nadila Vania, Risma Ananda Weliyanto, Yupi Wineiniati, Noni Wulandari, Suci Sri Yasnatasya Ys, Jian Yayuk Puji Lestari Yemima Hepriana Yuditha Mutia Windy Yuli Yanti Sholehah Yustian, Alifira Adhany Yuwindry, Iwan Zahratunnisa, Zahratunnisa Zhafirah, Nurul Zulianur, Riska Ali Zulliati Zulliati