This study aims to determine the relationship between critical thinking skills and creative thinking skills with the biology learning outcomes of grade XI students at UPT SMAN 1 Wajo. This study is based on the demands of 21st century learning, which emphasizes the development of higher-order thinking skills, such as critical and creative thinking, in biology lessons. This study used a descriptive-quantitative method. The research population consisted of 11th grade students at UPT SMAN 1 Wajo, and the sample was taken using purposive sampling of 31 students. The results showed a positive and significant relationship between critical thinking skills and creative thinking skills with students' biology learning outcomes, with a significance value of 0.000 < 0.05 and a correlation coefficient value of 0.972, which is classified as a very strong correlation. This study concluded that simultaneously, higher critical thinking skills and creative thinking skills play an important role in improving students' biology learning outcomes.
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