Aktivitas Penghambatan Ekstrak Etanol Daun Cassia Spectabilis Terhadap Pertumbuhan Plasmodium falciparum dan Plasmodium berghei

Wiwied Ekasari (Departemen Farmakognosi dan Fitokimia, Fakultas Farmasi, Universitas Airlangga, Surabaya)
Nindya Tresiana (Departemen Farmakognosi dan Fitokimia, Fakultas Farmasi, Universitas Airlangga, Surabaya)
Suciati Iryani (Departemen Farmakognosi dan Fitokimia, Fakultas Farmasi, Universitas Airlangga, Surabaya)
Tutik Sri Wahyuni (Departemen Farmakognosi dan Fitokimia, Fakultas Farmasi, Universitas Airlangga, Surabaya)
Heny Arwaty (Departemen Parasitology, Fakultas Kedokteran, Universitas Airlangga, Surabaya)

JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Vol. 3 No. 1 (2016): Jurnal Farmasi dan Ilmu Kefarmasian Indonesia

Background: Antimalarial screening against nine species of the genus Cassia showed that the methanol extract of leaves Cassia spectabilis have the highest activity. Since it will be used as a traditional medicine, hence it is needed further studies of antimalarial activity of these plants by choosing a safer solvent, namely ethanol. Objective: In vitro anti-malarial activity against Plasmodium falciparum was conducted using the method of Trager and Jensen. Methods: The serial solution tested were: 100, 10, 1,  0.1 and 0.01 µg/ mL, while the in vivo test was performed based on Peter's test (The days suppressive test) that using P. berghei (strain ANKA) infected mice. Results: The results showed that ethanolic extract of C. spectabilis leaves has inhibitory activity against P. falciparum with IC50 value of 12.52 µg/ mL and against P. berghei with ED50 value of 131.5 mg/kg body weight. Conclusions: A further study to see the potential of ethanol extract from C. Spectabilis leaves as anti-malaria is warranted.