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All Journal Pharmaciana: Jurnal Kefarmasian Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan Berkala Kedokteran JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Penelitian Kesehatan Suara Forikes Indonesian Journal of Chemistry SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Biosaintifika: Journal of Biology & Biology Education Jurnal Pemberdayaan: Publikasi Hasil Pengabdian Kepada Masyarakat PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat J-Dinamika: Jurnal Pengabdian Kepada Masyarakat Jurnal Pengabdian Masyarakat Asia Jurnal Kreativitas dan Inovasi (Jurnal Kreanova) Jurnal Masyarakat Madani Indonesia Borneo Journal of Pharmacy
Wiwied Ekasari
Fakultas Farmasi Universitas Airlangga
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Other

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The Effectiveness of Local Plants from Lom and Sawang Ethnics as Antimalarial Medicine Helmi, Henny; Afriyansyah, Budi; Ekasari, Wiwied
Biosaintifika: Journal of Biology & Biology Education Vol 8, No 2 (2016): September 2016
Publisher : Department of Biology, Faculty of Mathematics and Sciences, Semarang State University . Ro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/biosaintifika.v8i2.5437

Abstract

Native people or ethnic societies that live in endemic malaria islands such as in Bangka Island and Belitung Island have used many medicinal plants to cure malaria. Leaves of kesembung (Scaevola taccada (Gaertn Roxb), roots of kebentak (Wikstroemia androsaemofolia Decne), and roots of medang mencena (Dapniphyllum laurinum (Benth) are the examples. This research was aimed to investigate the present of some biochemical compound and evaluate the antimalarial activity of ethanol extract of the plants against Plasmodium falciparum 3D7 in vitro. The IC50 level was determined through visual observation under microscope over 5000 of giemsa-stained erythrocytes then analyzed by probit analysis. Results showed that kebentak root ethanol extract was effective to inhibit P. falciparum 3D7 with level 0.485 g/mL. Furthermore, the IC50 level of kesembung leaves and medang root were 44.352 g/mL and 1486.678 g/mL respectively. Phytochemical test result showed that kebentak leaf ethanol crude extract contained triterpenoid, kesembung root contained phenol and tannins; moreover, medang root contained alkaloid, saponin, and triterpenoid.How to CiteHelmi, H., Afriyansyah, B. & Ekasari, W. (2016). The Effectiveness of Local Plants from Lom and Sawang Ethnics as Antimalarial Medicine. Biosaintifika: Journal of Biology & Biology Education, 8(2), 193-200.
Profil Fitokimia Ekstrak Etanol Bunga Kasumba Turate (Carthamus tinctorius L.) yang Berpotensi Sebagai Antimalaria Hamsidi, Rini; Widyawaruyanti, Aty; Hafid, Achmad Fuad; Ekasari, Wiwied; Malaka, Muhammad Hajrul; Kasmawati, Henny; Akib, Nur Illiyyin; Wahyuni, W; Sabarudin, S
Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan Vol 4, No 2 (2018): Pharmauho
Publisher : Fakultas Farmasi Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (119.085 KB) | DOI: 10.33772/pharmauho.v4i2.6267

Abstract

Bunga Kasumba turate (Carthamus tinctorius Linn) dari suku Asteraceae merupakan tumbuhan obat tradisional etnis Sulawesi Selatan yang secara empiris digunakan dalam pengobatan campak. Ekstrak etanol dari kasumba turate memberikan peningkatan aktivitas imunoglobulin G (IgG) dan  aktivitas imunoglobulin A (IgA) yang sangat signifikan. Penelitian menunjukkan ekstrak etanol bunga C. Tinctorius L memiliki potensi sebagai antimalaria secara in vitro dengan nilai IC50 sebesar 1,06 µg/ml. Sampel bunga C. tinctorius L. kering sebanyak 3 Kg dicacah hingga menjadi serbuk sebanyak 870 gram kemudian diekstraksi secara maserasi dengan menggunakan pelarut etanol 80%. Hasil maserasi dipekatkan dengan vacuum rotary evaporator pada suhu 50°C sehingga diperoleh ekstrak kental sebanyak 178,7gram. Profil fitokimia menunjukkan ekstrak etanol bunga C. tinctorius L. mengandung senyawa metabolit antara lain saponin, terpenoid, flavonoid, tanin dan antrakuinon.Kata kunci: Skrining, ekstrak, kasumba turate, obat tradisional, antimalaria
PELATIHAN PEMBUATAN ES KRIM HERBAL DAN INOVASI KEMASAN PRODUK JAMU DI DUSUN KIRINGAN-JETIS, BANTUL, YOGYAKARTA Widyowati, Retno; Ekasari, Wiwied; Purwitasari, Neny; Widyawaruyanti, Aty; Sukardiman, Sukardiman; Wahyuningsih, Iis
Jurnal Pemberdayaan: Publikasi Hasil Pengabdian Kepada Masyarakat Vol 4, No 1 (2020)
Publisher : Universitas Ahmad Dahlan, Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (196.661 KB) | DOI: 10.12928/jp.v4i1.1200

Abstract

Dusun Kiringan-Jetis, Bantul, merupakan desa wisata jamu gendong dengan penduduk mayoritas berprofesi sebagai pengrajin jamu. Jamu yang mereka jual secara turun-temurun terbatas dalam bentuk jadi dan setengah jadi. Perlu adanya peningkatan diversifikasi produk jamu untuk meningkatkan nilai jualnya. Kegiatan pengabdian pada masyarakat ini bertujuan untuk meningkatkan ketrampilan usaha dalam meningkatkan kualitas dan mengembangkan produk jamu yang akan dijual. Untuk dapat mencapai tujuan yang diinginkan dari kegiatan ini maka dilakukan upaya: (1) Edukasi dan pelatihan ketrampilan membuat es krim herbal dan (2) edukasi dan pelatihan ketrampilan membuat inovasi kemasan produk jamu yang aman dan menarik.Tim pelaksana kegiatan ini terdiri dari dosen dan mahasiswa S1 Fakultas Farmasi Universitas Airlangga dan Universitas Ahmad Dahlan. Dari kegiatan tersebut terlihat antusias para peserta pelatihan, peningkatan pengetahuan dan ketrampilan dalam pembuatan es krim herbal dan inovasi kemasan produk. Hal ini terlihat dari peningkatan skor post-testsetelah dilakukan pelatihan.Besar harapan para peserta kegiatan untuk dapat mengaplikasikan pengetahuan yang didapat sehingga dapat meningkatan perekonomian Dusun Kiringan-Jetis, Yogyakarta
PENGGUNAAN OBAT TRADISIONAL UNTUK PENANGANAN PENYAKIT DIABETES DI KECAMATAN KENJERAN SURABAYA Wiwied Ekasari
Dharmakarya Vol 8, No 4 (2019): Desember 2019
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/dharmakarya.v8i4.20944

Abstract

Wilayah Kenjeran yang menjadi lokasi pengabdian masyarakat ini merupakan wilayah binaan Universitas Airlangga sampai saat ini. Berdasar data pengabdian masyarakat di tahun sebelumnya, ditemukan banyak penyakit degeneratif utamanya penyakit diabetes yang menjangkit pada penduduk wilayah Kenjeran dengan penanganan yang belum maksimal karena kurangnya pengetahuan bagaimana mencegah dan mengobati baik menggunakan obat tradisional maupun obat modern. Untuk itu dilakukan pengabdian masyarakat dengan menggunakan metode penyuluhan/ edukasi tentang cara memanfaatkan tanaman obat yang telah terbukti secara ilmiah mempunyai aktivitas dapat menurunkan kadar gula dalam darah. Juga diberikan informasi mengenai penyakit diabetes, cara menyiapkan dan mengolah obat tradisional sehingga siap dikonsumsi oleh diri sendiri maupun keluarganya dalam mencegah dan mengobati penyakit Diabetes mellitus. Berdasarkan hasil kegiatan pengabdian masyarakat yang telah dilakukan dapat disimpulkan bahwa pengetahuan para peserta kader PKK kecamatan Kejeran Surabaya tentang obat tradisonal untuk penyakit diabetes menunjukkan adanya peningkatan yang bermakna setelah diberikan penyuluhan. 
The Knowledge of Lombok Praya-Indonesia Regional Community on the Safety Use of Medicinal Plants Wiwied Ekasari; Suko Hardjono; Sugijanto Sugijanto; Juni Ekowati; I Nyoman Wijaya; Tri Widiandani
Berkala Kedokteran Vol 17, No 2 (2021)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (215.127 KB) | DOI: 10.20527/jbk.v17i2.11671

Abstract

Abstract: The use of medicinal plants to maintain or overcome health problems has long been carried out by worldwide community. Along with the development of knowledge, data about the existence of undesirable effects or side effects associated with the use of medicinal plants that are not appropriate are obtained. This research is conducted to determine public knowledge about the safety several medicinal plants use. The study was conducted with a questionnaire technique in Lombok Praya, Indonesia. The results show that knowledge about the safety of the use of medicinal plants in breastfeeding mothers obtains the correct answer by 48%, knowledge about the parts of medicinal plants that are dangerous for consumption by 39% and knowledge about medicinal plants that can increase health risks by 21%. Whereas, the knowledges for the use of medicinal plants in pregnant women and the use of medicinal plants that are not right obtains very good results with correct answers of 79% and 81%. Based on further interviews, these good results are obtained because they are supported more by traditional use of the plant that has already existed in the area. Public understanding of the safety of some medicinal plants in Lombok Praya is still lacking. It is necessary to add knowledge about the use of medicinal plants that requires special attention, especially on plants that are often used by people in the area. Local health agencies need to disseminate information on the safety of medicinal plants that is wider and more sustainable. Keywords: Community, medicinal plant, safety, public understanding.
Aktivitas Penghambatan Ekstrak Etanol Daun Cassia Spectabilis Terhadap Pertumbuhan Plasmodium falciparum dan Plasmodium berghei Wiwied Ekasari; Nindya Tresiana; Suciati Iryani; Tutik Sri Wahyuni; Heny Arwaty
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 3 No. 1 (2016): Jurnal Farmasi dan Ilmu Kefarmasian Indonesia
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (53.699 KB) | DOI: 10.20473/jfiki.v3i12016.17-21

Abstract

Background: Antimalarial screening against nine species of the genus Cassia showed that the methanol extract of leaves Cassia spectabilis have the highest activity. Since it will be used as a traditional medicine, hence it is needed further studies of antimalarial activity of these plants by choosing a safer solvent, namely ethanol. Objective: In vitro anti-malarial activity against Plasmodium falciparum was conducted using the method of Trager and Jensen. Methods: The serial solution tested were: 100, 10, 1,  0.1 and 0.01 µg/ mL, while the in vivo test was performed based on Peter's test (The days suppressive test) that using P. berghei (strain ANKA) infected mice. Results: The results showed that ethanolic extract of C. spectabilis leaves has inhibitory activity against P. falciparum with IC50 value of 12.52 µg/ mL and against P. berghei with ED50 value of 131.5 mg/kg body weight. Conclusions: A further study to see the potential of ethanol extract from C. Spectabilis leaves as anti-malaria is warranted. 
In Vitro Antimalarial Activity and Toxicity of Helianthus annuus L. Leaf Extract against Plasmodium falciparum Nuriha Marangoh; Suciati Suciati; Wiwied Ekasari
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 8 No. 3 (2021): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v8i32021.259-263

Abstract

Background: Malaria is one of the public health problems in Indonesia. The morbidity rate is still quite high, especially in the eastern part of Indonesia. Objective: This study aimed to determine the inhibitory activity of the leaf extracts of Helianthus annuus L. against Plasmodium falciparum strain 3D7 as well as the cytotoxicity of the extracts. Methods: The leaves of H. annuus were extracted by the maceration method with n-hexane, chloroform, and ethanol 96% to increase polarity. The antimalarial assay was performed by using Trager and Jensen method, and the cytotoxicity test was carried out by the MTT method. Results: The results of antimalarial study showed that the chloroform extract had IC50 value of 0.002 µg/mL and CC50value of 138.03 µg/mL, 96% ethanol extract had an IC50 value of 0.02 µg/mL and CC50 value of 617.81 µg/mL, and n-hexane extract had an IC50 value of 1.29 µg/mL and CC50 value of 104.89 µg/mL. The selectivity index (SI) values of the chloroform, ethanolic, and n-hexane extracts were calculated and obtained 69,015.00, 30,890.50, and 81.31, respectively. Conclusion:  To conclude, the chloroform extract of H. annuus L. leaf gave strong antimalarial activity against P. falciparum strain 3D7 without any cytotoxicity; therefore, H. annuus L. leaf can be a good candidate for the development of an antimalarial drug.
PELATIHAN PEMBUATAN ES KRIM HERBAL DAN INOVASI KEMASAN PRODUK JAMU DI DUSUN KIRINGAN-JETIS, BANTUL, YOGYAKARTA Retno Widyowati; Wiwied Ekasari; Neny Purwitasari; Aty Widyawaruyanti; Sukardiman Sukardiman; Iis Wahyuningsih
Jurnal Pemberdayaan: Publikasi Hasil Pengabdian Kepada Masyarakat Vol. 4 No. 1 (2020)
Publisher : Universitas Ahmad Dahlan, Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/jp.v4i1.1200

Abstract

Dusun Kiringan-Jetis, Bantul, merupakan desa wisata jamu gendong dengan penduduk mayoritas berprofesi sebagai pengrajin jamu. Jamu yang mereka jual secara turun-temurun terbatas dalam bentuk jadi dan setengah jadi. Perlu adanya peningkatan diversifikasi produk jamu untuk meningkatkan nilai jualnya. Kegiatan pengabdian pada masyarakat ini bertujuan untuk meningkatkan ketrampilan usaha dalam meningkatkan kualitas dan mengembangkan produk jamu yang akan dijual. Untuk dapat mencapai tujuan yang diinginkan dari kegiatan ini maka dilakukan upaya: (1) Edukasi dan pelatihan ketrampilan membuat es krim herbal dan (2) edukasi dan pelatihan ketrampilan membuat inovasi kemasan produk jamu yang aman dan menarik.Tim pelaksana kegiatan ini terdiri dari dosen dan mahasiswa S1 Fakultas Farmasi Universitas Airlangga dan Universitas Ahmad Dahlan. Dari kegiatan tersebut terlihat antusias para peserta pelatihan, peningkatan pengetahuan dan ketrampilan dalam pembuatan es krim herbal dan inovasi kemasan produk. Hal ini terlihat dari peningkatan skor post-testsetelah dilakukan pelatihan.Besar harapan para peserta kegiatan untuk dapat mengaplikasikan pengetahuan yang didapat sehingga dapat meningkatan perekonomian Dusun Kiringan-Jetis, Yogyakarta
ISOLATION AND PRESENCE OF ANTIMALARIAL ACTIVITIES OF MARINE SPONGE Xestospongia sp. Murtihapsari Murtihapsari; Apriani Sulu Parubak; Bertha Mangallo; Wiwied Ekasari; Puji Budi Asih; Ayu Indah Lestari
Indonesian Journal of Chemistry Vol 13, No 3 (2013)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (675.305 KB) | DOI: 10.22146/ijc.21276

Abstract

Plasmodium falciparum, the agent of malignant malaria, is one of mankind's most severe scourges, mainly in the tropic world. Efforts to develop preventive vaccines or remedial drugs are handicapped by the parasite's rapid evolution of drug resistance. Here, we presented an advance work on examination of antimalarial component from marine life of Xestospongia sp., the study is based on hexane extraction method. The premier result, we obtained five fractions. Among these five fractions, the fourth has the most potent inhibitory against the growth of P. falciparum 3D7 with an IC50: 7.13 µg/mL. A compiled spectrum analysis, FTIR, 1H-NMR and GC-MS, revealed that the fourth fraction consisted abundantly of two secondary metabolites such as flavonoids and triterpenoids. Finally, our results suggest a plausible structure rooted to the base of ibuprofen.
Standardization of Cassia spectabilis DC leaves and antimalarial activities of ethyl acetate extract Wiwied Ekasari; Heny Arwati; Nindya Tresiana Putri; Dewi Hariyani; Rosalia Friska Ananda; Eko Suhartono
Pharmaciana Vol 12, No 2 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (108.761 KB) | DOI: 10.12928/pharmaciana.v12i2.23598

Abstract

Cassia spectabilis is one of the Indonesian medicinal plants traditionally used to treat different diseases, including malaria. Quality of a drug derived from plants is also influenced by the quality of its raw materials. Thus, in order to assure the quality of products made from plants, it is necessary to standardize the raw materials and following with the antimalarial activity test. The aim of this study was to standardize the quality of C. spectabilis leaves and to evaluate its antimalarial activities of ethyl acetate extract. The fresh material of C. spectabilis leaves were observed its specific and non-specific parameters. In vitro test was done by using Plasmodium falciparum 3D7. In vivo test was done using 4-day suppressive test method against mice infected with P. berghei for four consecutive days. Heme detoxification inhibitory activity test was carried out using the modified Basilico method. The leaves of C. spectabilis meet the quality requirement for raw material of traditional medicine. The ethyl acetate extract showed in vitro antiplasmodial activity against P. falciparum 3D7 and in vivo antimalarial activity against P. berghei infection with IC50 value of 27.28 μg/mL and ED50 value of 1.74 mg/kg, respectively. The extract also showed heme detoxification inhibitory activity with IC50 value of 0.33±0.01 mg/mL. The leaves of C. spectabilis leaves meet the quality requirement and the ethyl acetate extract from standardized C. spectabilis leaves possessed a potential an antimalarial activity which deserves to be further developed.
Co-Authors A. Mu’thi Andy Suryadi Abdul Rahman Achmad Fuad Hafid Achmad Toto Poernomo AGUS HARIANTO Agus Pratiwi Akbar, Jasmine Aulia Andang Miatmoko Anisa Tri Hutami Apriani Sulu Parubak Ario Imandiri, Ario Arum Widiyaningsih Aty Widyawaruyanti Ayu Indah Lestari Bertha Mangallo Budi Afriyansyah Budi Afriyansyah Dahri, Baso Devanus Lahardo Dewi Hariyani Dewi Melani Hariyadi Diyah, Nuzul Wahyuning Eko Suhartono Esti Hendradi Faisal Akhmal Muslikh Fatin Fadhilah Hasib Fatmawati, Annisa Firmansyah Ardian Ramadhani Gerriandi, Aqila Aqhnia Hadi Poerwono Handayani, Rosita Hanifa Rahma Putri Haula, Hamizah Henny Helmi Heny Arwati Heny Arwaty Herra Studiawan Hilkatul Ilmi I NYOMAN WIJAYA Idayati, Dihan Isro Idha Kusumawati Iis Wahyuningsih Ilmi, Hilkatul Imelda, Viola Puspa Irawati Sholikhah Isnaeni Isnaeni Iswahjuni, Iswahjuni Iswajuni, Iswajuni Juni Ekowati Kasmawati, Henny Kholis Amalia Nofianti Lahardo, Devanus Lidya Tumewu Malaka, Muhammad Hajrul Marcellino Rudyanto Maria Lucia Ardhani Dwi Lestari Melanny Ika Sulistyowaty Miatmoko, Andang Minnah, Fakhrina Fauzul Munandar, Tristiana Erawati Murtihapsari Murtihapsari Nindya Tresiana Nindya Tresiana Putri Nirmala, Afrida Yunda Nugroho, Novreza Avistha Nur Illiyyin Akib Nuriha Marangoh Paramita, Diajeng Putri Prayogo, Ega Widya Puja Adi Priatna Puji Budi Asih Purbiastuti, Putri Ayu Purwitasari, Neny Putri, Lailatul Pratama Putri, Nindya Tresiana Rahmadani, Andini Putri Ram Kumar Sahu Ramadhani, Firmansyah Ardian Retno Sari Retno Widyowati Rice Disi Oktarina Rini Hamsidi Rosalia Friska Ananda Sabarudin Sabarudin Sri Wahyuni, Tutik Suciati Suciati Suciati Suciati Sudjarwo Sudjarwo Sudjarwo Sudjarwo Sugijanto Sugijanto Sukardiman Suko Hardjono Suryanto, Suryanto Syahrani, Achmad Tjandra, Edbert Rafael Tri Widiandani Tutiek Purwanti Tutik Sri Wahyuni W Wahyuni, W Wahjo Djatmiko Wicaksana, Firman Widyowati, Rr. Retno Wijayanti, Galuh Candra Yanu Andhiarto Yuliana, Khalifah Yusuf Alif Pratama