Jurnal Insan Farmasi Indonesia
Vol 8 No 2 (2025): Jurnal Insan Farmasi Indonesia

FORMULASI SEDIAAN SIRUP SENGKUANG Dracontomelon dao (Blanco) Merr & Rofle DAN UJI EFEKTIVITASNYA SEBAGAI ANTELMINTIK

inderiyani, Inderiyani (Unknown)
Puspasari, Heny (Unknown)
Puspita, Weni (Unknown)
Febrianti, Ririn (Unknown)



Article Info

Publish Date
31 Dec 2025

Abstract

The bark of the sengkuang Dracontomelon dao (Blanco) Merr & Rofle stem contains secondary metabolites alkaloids, saponins, tannins, flavonoids and triterpenoids which are efficacious as anthelmintics. This study aims to formulate, physically evaluate and test the effectiveness of sengkuang stem bark ethanol extract syrup as anthelmintic against chicken roundworms (Ascaridia galli). The syrup preparation was formulated in 3 variations of extract concentrations i.e 0.2%; 0.4% and 0.6%. The syrup was physically evaluated in the form of organoleptic tests, pH, displaced volume and specific gravity.  Inserting 5 chicken roundworms into each test solution i.e 0.9% NaCl (negative control), 0.5% mebendazole (positive control), sengkuang stem bark syrup 0.2%, 0.4%, and 0.6%. It was incubated at 37°C and the time and number of worm deaths were observed every 1 hour for 24 hours. The results showed the sengkuang bark ethanol extract syrup (0.2%; 0.4% and 0.6%) met the requirements in syrup preparations with brownish yellow, brownish orange and brown colors, distinctive aroma and sweet taste; pH ± 6; displaced volume ± 97-98% and specific gravity ± 1.2. All sengkuang bark ethanol extract syrup formulations had the ability to kill 100% of worms with LT50 values ​​of 11.40 hours; 10.33 hours and 6.87 hours.

Copyrights © 2025






Journal Info

Abbrev

JIFI

Publisher

Subject

Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Physics

Description

Focus and Scope Jurnal Insan Farmasi Indonesia (JIFI) is a broad-based primary journal covering all branches of pharmacy and its sub-disciplines that contains complete research articles, short communication and review articles. JIFI is a forum for the publication of quality and original works that ...