Evaluation of the Effectiveness of Dragon Tail Leaf Extract (Rhaphidophora pinnata (Lf) Schott) on Incisional Wound Healing in White Rats (Rattus norvegicus)

Joke L. Tombuku (Department of Biology, Faculty of Mathematics and Natural Sciences, Christian University of Indonesia in Tomohon)
Kristin Mosso (Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Christian University of Indonesia in Tomohon)
Jeane Mongi (Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Christian University of Indonesia in Tomohon)
Nerni O. Potalangi (Department of Biology, Faculty of Mathematics and Natural Sciences, Christian University of Indonesia in Tomohon)
Hanna M. Rumagit (Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Christian University of Indonesia in Tomohon)
Rahmat Santoso (Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Christian University of Indonesia in Tomohon)
Amal R. Ginting (Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Christian University of Indonesia in Tomohon)

Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical)
Vol. 8 No. 2 (2025): OKTOBER 2025

Rhaphidophora pinnata (dragon tail leaf) has traditionally been used as a medicinal plant for treating wounds. This research aimed to evaluate the effectiveness of Rhaphidophora pinnata leaf extract on incision wound healing in male white rats (Rattus norvegicus). The study employed a laboratory experimental design using 15 rats divided into five treatment groups: negative control (aquades), positive control (povidone iodine), and topical extract concentrations of 15%, 20%, and 25%. Wound length was measured daily for 14 days. Statistical analysis using paired sample t-test showed a significant difference between pre-treatment and post-treatment wound conditions (p = 0.000 < 0.05; t = 5.391). The results demonstrated that all extract concentrations accelerated wound closure, with the 25% concentration showing the greatest healing effect and complete wound closure by day 14. These findings indicate that Rhaphidophora pinnata leaf extract is effective in promoting incision wound healing, particularly at a concentration of 25%.