<![CDATA[Plant Physiology is a compulsory course in the biology and biology education study program. The material has a high conceptual complexity, presenting physiological processes, including biochemistry, cellular biology, molecular, genetics, and environmental interactions which constitute the complexity of science. Interdisciplinary, requiring students to integrate knowledge from various disciplines. Interviews revealed that the material is complex, encompassing the study of cells, anatomy, biochemistry, and their relationship to the environment. The available teaching materials are primarily PowerPoint presentations. Lecturers lack teaching materials that adequately explain the mechanisms that occur within the plant body. One effective approach is to utilize interactive digital textbooks equipped with Augmented Reality (AR) and Virtual Reality (VR). This research aims to develop an interactive digital with AR and VR for the Plant Physiology. This research is a developmental study using the 4D model. This study was limited to the development stage, which aimed to determine the validity of the digital book. The instrument used was a digital book validity analysis questionnaire. Data analysis used the percentage formula. The results of the study show that the interactive digital book equipped with AR and VR in the plant physiology course is valid with a validation value of 91.82%.]]>
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