PharmaCine: Journal of Pharmacy, Medical and Health Science
Vol. 6 No. 2 (2025): PharmaCine: Journal of Pharmacy, Medical and Health Science

Optimasi Formula Granul Effervescent Ekstrak Rimpang Temu Putih (Curcuma zedoaria) dengan Variasi Pemanis Alami sebagai Antioksidan: Optimization and Antioxidant Evaluation of Effervescent Granules Containing White Turmeric (Curcuma zedoaria) Rhizome Extract with Natural Sweeteners

Diki Zaelani (Kelompok Keilmuan Farmasetika dan Teknologi Farmasi, Fakultas Farmasi, Universitas Bhakti Kencana)
Ratu Siti Robiatul Awaliyah (Kelompok Keilmuan Farmasetika dan Teknologi Farmasi, Fakultas Farmasi, Universitas Bhakti Kencana)
Rahmat Santoso (Kelompok Keilmuan Farmasetika dan Teknologi Farmasi, Fakultas Farmasi, Universitas Bhakti Kencana)
Emma Emawati (Kelompok Keilmuan Analisis Farmasi, Fakultas Farmasi, Universitas Bhakti Kencana)
Reza Pratama (Kelompok Keilmuan Farmasetika dan Teknologi Farmasi, Fakultas Farmasi, Universitas Bhakti Kencana)



Article Info

Publish Date
30 Sep 2025

Abstract

White turmeric (Curcuma zedoaria), a member of the Zingiberaceae family, contains bioactive compounds with antioxidant potential, but its utilization remains limited due to its bitter taste and less practical traditional preparations. This study aimed to optimize the formulation of effervescent granules containing white turmeric rhizome extract using different natural sweeteners and to evaluate their physical properties and antioxidant activity. The effervescent granules were prepared by the wet granulation method using stevia (F1, 17.5%), palm sugar (F2, 10%), and corn sugar (F3, 14.5%) as sweeteners. The granules were evaluated for physical characteristics (organoleptic properties, moisture content, flow rate, angle of repose, dissolution time, pH, foam height, and hedonic test) and antioxidant activity using the DPPH method both qualitatively and quantitatively. The results showed that all formulas met the standard physical requirements of effervescent granules. The best formulation was obtained from F3 (corn sugar) with the highest acceptance score in the hedonic test. The antioxidant activity of white turmeric extract exhibited an IC₅₀ value of 53.53 ppm, while the effervescent granules showed strong antioxidant activity with IC₅₀ values of 62.53 ppm (F1), 62.62 ppm (F2), and 62.79 ppm (F3). These findings indicate that variations in natural sweeteners influence the sensory characteristics without significantly reducing the antioxidant potency of the formulation. Keywords: Effervescent granules; Curcuma zedoaria; Natural sweeteners; Antioxidant, Formulation optimization.

Copyrights © 2025






Journal Info

Abbrev

pharmac

Publisher

Subject

Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Veterinary

Description

PharmaCine: Journal of Pharmacy, Medical, and Health Sciences is a peer-reviewed journal dedicated to scientific publications in the fields of pharmacy, medicine, and health sciences. PharmaCine is published biannually, in March and September, by the Undergraduate Pharmacy Program, Faculty of Health ...