Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for pain and inflammation, yet their potential impact on sleep quality remains uncertain. This study aimed to examine the relationship between NSAID use and insomnia symptoms among adults in a hospital setting. A descriptive cross-sectional study was conducted at RSI Jemursari Hospital, Surabaya, using medical records and structured questionnaires to assess sleep quality among NSAID users. Participants were grouped based on drug type, duration, and frequency of use. Statistical analyses employed Pearson’s correlation and Chi-square tests. Results showed that long-term or frequent NSAID use was significantly associated with a higher prevalence of sleep disturbances, particularly difficulty initiating and maintaining sleep (r = 0.46, p = 0.02). Psychological stress and chronic pain also aggravated insomnia severity. These findings suggest a complex interaction between analgesic therapy and sleep regulation, emphasizing the need for clinicians to assess sleep health during prolonged NSAID administration. Integrating sleep evaluation into pain management protocols may help improve both therapeutic outcomes and patient well-being.
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