Biology, Medicine, & Natural Product Chemistry
Vol 15, No 1 (2026)

Regenerative Hematinic Properties of Mondia whitei Root Aqueous Extract in Phenylhydrazine Hydrochloride-Induced Anemia in Female Wistar Rats

MacDonald Idu (University of Benin)
Benjamin Ogunma Gabriel (University of Benin)
Aye-Mola Glory Dudun (University of Benin)
Rametu Momodu (NAFDAC House, plot I, Apapa-Oshodi Express way, Isolo Industrial Complex, Lagos State Nigeria)



Article Info

Publish Date
31 Aug 2026

Abstract

Anaemia, a medical condition worldwide, is of significant concern as it lowers hemoglobin or red blood cell levels, causing potential risk or death to patients. This study investigates the hematinic properties of Mondia whitei on phenylhydrazine hydrochloride-induced anaemic rats. Freshly prepared root of M. whitei was chopped into pieces, washed, shade-dried, and processed into aqueous extract. Phenylhydrazine hydrochloride (40 mg/kg) was administered across the groups for 3 days to induce anaemia in female Wistar rats. M. whitei extract (25, 50,100 mg/kg) and reference drug (folate 5 mg/kg) were orally administered for 7 days across the treatment groups, and hematological, peripheral blood smear, and histopathology parameters were analyzed. The results obtained from this study showed that the root extract exhibited a significant difference in the hematinic properties (red blood cells and their components, peripheral blood smear, and regeneration and rapid maturation of blood cells with normal blood morphology) across graded doses of the extract when compared with the untreated control p>0.05. The plant's traditional use in managing anaemia was scientifically validated, hence further studies are warranted to elucidate the implicated compound-to-compound isolation-guided bioassay.

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Journal Info

Abbrev

BIOMEDICH

Publisher

Subject

Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health

Description

BIOLOGY, MEDICINE, & NATURAL PRODUCT CHEMISTRY, this journal is published to attract and disseminate innovative and expert findings in the fields of plant, animal, and microorganism secondary metabolite, and also the effect of natural product on biological system as a reference source for ...