This study aims to examine the influence of safety knowledge and safety climate on safety performance with safety behavior as a mediating variable in nurses at Ananda General Hospital, Jatiwinangun General Hospital, and Wijayakusuma Hospital. This study reviews the increasing concern for occupational safety in the healthcare sector, where nurses have high levels of exposure to biological risks, procedural errors, and intense workloads that can impact both workforce safety and patient safety. A total of 203 nurses participated as respondents, and data were collected using a standardized survey instrument. The analysis was conducted using Structural Equation Modeling (SEM) to evaluate the direct and indirect relationships between variables. The results showed that safety knowledge had no effect on safety performance, safety climate had an effect on safety performance, safety knowledge had an effect on safety behavior, safety climate had an effect on safety behavior, safety behavior had an effect on safety performance, safety behavior mediated the effect of safety knowledge on safety performance, and safety behavior mediated safety climate on safety performance. This conclusion indicates that understanding safety procedures and working in an environment with a good safety climate tends to increase safety behavior. The influence of both is strengthened through safety behavior as a mediator, which reflects the effectiveness of implementing safety practices in hospitals.
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