Background: Hyperthyroidism is an endocrine disorder caused by the excessive production of thyroid hormones, which can lead to complications if not properly managed. Treatment success in patients with hyperthyroidism is influenced by medication adherence. Purpose: To determine the relationship between medication adherence and treatment success in patients of productive age with hyperthyroidism. Method: This was an analytic observational study with a cross-sectional design. The study sample consisted of 54 respondents selected using purposive sampling. Adherence levels were measured using the Morisky Medication Adherence Scale-8 (MMAS-8) questionnaire, while treatment success was assessed based on thyroid hormone test results and clinical symptom improvement recorded in patient medical records. Data analysis was conducted using univariate and bivariate methods, employing the chi-square test. Results: The results show that the respondents' mean TSH levels decreased from 6.87 mIU/L to 3.21 mIU/L following therapy. The majority of respondents demonstrated adherence levels ranging from low to high and achieved successful therapeutic outcomes. There is an association between medication adherence and therapeutic success in patients with hyperthyroidism. Conclusion: Medication adherence is associated with therapeutic success in hyperthyroid patients of working age. The higher the level of patient adherence to treatment, the greater the therapeutic success achieved. Suggestion: Ongoing education, monitoring, and support from healthcare professionals are required to improve patient adherence. Keywords: Health Belief Model; Hyperthyroidism; Medication Adherence; MMAS-8; Treatment Success.
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