<![CDATA[Background: Platelet activity in diabetes mellitus is a concern because platelets play a role in thrombus formation and atherothrombosis. Platelet activity can be assessed through platelet indices, which include the Mean Platelet Volume (MPV), Platelet Distribution Width (PDW), Plateletcrit (PCT), and Platelet Large Cell Ratio (P-LCR), providing an indirect reflection of platelet characteristics. Changes in these parameters may be associated with an increased risk of cardiovascular complications in patients with diabetes mellitus. Objective: This study aims to evaluate platelet activity and analyze its relationship with blood glucose levels in patients with diabetes mellitus. Methods: This study employed an analytical observational design with a cross-sectional approach. The sample consisted of 50 patients with type 2 diabetes mellitus participating in the Chronic Disease Management Program (Prolanis) at the Praya Community Health Center, selected through purposive sampling. Data on blood glucose levels and platelet indices were analyzed using Pearson’s correlation test. Results: The examination results showed a mean blood glucose level of 148.42 mg/dL. Meanwhile, the mean platelet indices were as follows: PDW 16.1%; MPV 9.59 fL; P-LCR 24.43%; and PCT 2.6 mL/L. The results of the Pearson correlation test showed that blood glucose levels were correlated with PDW (r = 0.131; p = 0.364), PCT (r = 0.148; p= 0.305), P-LCR (r = 0.213; p=0.138), and MPV (r=0.182; p=0.206). Conclusion: Platelet indices in patients with diabetes mellitus were generally within the normal range. Blood glucose levels showed a tendency toward a positive correlation with platelet indices, but no  statistically significant relationship was found]]>
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