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All Journal Meditory : The Journal of Medical Laboratory Jurnal Analis Medika Biosains (JAMBS) Indonesian Health Issue Media Informasi Jurnal Teknologi Laboratorium Medik Borneo Journal of Indonesia Laboratory Students (JILTS)
Thomas Tandi Manu
Poltekkes Kemenkes Mataram
Biochemistry, Genetics & Molecular Biology Dentistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Differences In Creatinine Levels And Reticulocyte Values In CKD Patients Undergoing Epo And Non-Epo Therapy Thomas Tandi Manu; Hikmatul Lailli; I Wayan Getas
Jurnal Analis Medika Biosains (JAMBS) Vol. 13 No. 01 (2026): JURNAL ANALIS MEDIKA BIOSAINS (JAMBS)
Publisher : Poltekkes Kemenkes Mataram

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Abstract

Chronic kidney disease (CKD) is a condition of progressive and irreversible decline in kidney function. One of the main complications of CKD is anemia, caused by decreased erythropoietin (Epo) production by the kidneys. Epodi therapy is used to stimulate red blood cell production. Reticulocyte counts are used as an indicator of erythropoietic activity, while creatinine levels reflect the degree of kidney damage To determine the differences in creatinine levels and reticulocyte values between CKD patients undergoing Epo and non-Epo therapy.This study was a quantitative cross-sectional study. The sample consisted of 60 CKD patients, divided into two groups: 30 patients with Epo therapy and 30 patients without Epo therapy. Data were collected through medical records and analyzed using the independent T-test. The average creatinine level in the Epo group was 3.96 mg/dL, while in the Non Epo group it was 1.83 mg/dL. The average reticulocyte value in the Epo group was 0.64%, while in the Non Epo group it was 1.49%. The results of the independent T test statistical test obtained a P value of creatinine levels of 0.000_
Test Screening Hepatitis A dan Hepatitis B pada Masyarakat Di Wilayah Kerja Puskesmas Alas Barat Febriyanti Rizki Diana Lestari Diana; Rohmi; Thomas Tandi Manu; Siti Zaetun
Journal of Indonesia Laboratory Students (JILTS) Vol. 5 No. 1 (2026): Journal of Indonesia Laboratory Students
Publisher : Poltekkes Kemenkes Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32807/jilts.v5i1.91

Abstract

Latar Belakang: Test screening HAVAg dan HbsAg merupakan pemeriksaan untuk mendeteksi dini infeksi virus hepatitis A dan hepatitis B pada seseorang. Hepatitis sendiri merupakan penyakit peradangan pada hati yang dapat sembuh dengan sendirinya atau berkembang menjadi fibrosis (jaringan parut), sirosis, atau kanker hati. Wilayah Alas Barat masih menjadi wilayah yang memiliki angka infeksi hepatitis yang tinggi serta rendahnya informasi tentang hepatitis dan akses pelayanan laboratorium penanganan kasus hepatitis pada masyarakat sebagai latar belakang masalah. Tujuan Penelitian: Untuk menganalisis dan mengetahui hasil test screening Hepatitis A dan Hepatitis B pada Masyarakat yang terkena infeksi Hepatitis A dan Hepatitis B. Metode Penelitian: Metode yang digunakan dalam penelitian ini adalah secara deskriptif kualitatif dengan menggunakan pengumpulan data yaitu data primer dan sekunder. Hasil: Test screening pada Hepatitis A menunjukkan bahwa 20 sampel yang telah dilakukan test screening di dapatkan hasil Non-Reaktif/Negatif Hepatitis A (HAVag), sedangkan pada Hepatitis B di dapatkan hasil dari 80 sampel yang telah dilakukan test screening 20 sampel di antaranya menunjukkan hasil Reaktif/Positif Hepatitis B (HbsAg). Kesimpulan: Di wilayah Alas Barat tidak ditemukan virus Hepatitis A dan pada Hepatitis B ditemukan sekitar 25% penduduk Alas Barat terkena infeksi virus Hepatitis B.
THE EFFECT OF CHEMOTHERAPY ON BLOOD CELL COUNTS IN POST-MASTECTOMY BREAST CANCER PATIENTS Muhammad Haerunnizam; Pancawati Ariami; Thomas Tandi Manu; Lale Budi Kusuma Dewi
Meditory : The Journal of Medical Laboratory Vol. 13 No. 2 (2025): Meditory, Volume 13 No. 2 Tahun 2025
Publisher : Jurusan Teknologi Laboratorium Medis, Poltekkes Kemenkes Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33992/meditory.v13i2.4096

Abstract

Background: Post-mastectomy chemotherapy often causes myelosuppression, as do the numbers of erythrocytes, leukocytes, and platelets.Objective: To determine the effect of chemotherapy on the number of blood cells in post-mastectomy breast cancer patients.Methods: This study was a retrospective observational study. The population in the study was breast cancer patients who underwent chemotherapy  0 (Pre-chemotherapy) to 4 times after mastectomy at the NTB Provincial Hospital from January to December 2024. Sampling was done using non-probability sampling with a purposive sampling method, resulting in 68 samples.Results: In the study, the average number of erythrocytes from session 0 (Pre-chemotherapy) to session 4 was 4,23; 3,80; 3,67; 3,59, and 3,6 million cells/µL. Then, the average number of leukocytes from session 0 (Pre-chemotherapy) to session 4 was 7,208; 5,024; 4,739; 3,690, and 3,281 thousand cells/µL. Meanwhile, the average number of platelets from session 0 (Pre-chemotherapy) to session 4 was 386,251; 302,792; 275,760; 228,014, and 206,035 thousand cells/µL. Based on the Friedman test data analysis, the results showed a significance value of 0.001 < 0.05.Conclusions: There is an effect of chemotherapy on the number of blood cells in post-mastectomy breast cancer patients.
Pengaruh Pemberian Teh Hijau (Camellia Sinensis) Terhadap Kadar Asam Urat Pada Penderita Hiperurisemia Lisda Ramadhania; Lalu Srigede; Thomas Tandi Manu; I Wayan Getas
Jurnal Teknologi Laboratorium Medik Borneo Vol. 5 No. 2 (2025): Jurnal Teknologi Laboratorium Medik Borneo
Publisher : Institut Teknologi Kesehatan dan Sains Wiyata Husada Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35728/jutelmo.v5i2.2005

Abstract

Latar Belakang : Hiperurisemia adalah keadaan meningkatnya kadar asam urat dalam darah yang berpotensi menimbulkan komplikasi berupa gout artritis maupun gangguan kardiovaskular. Teh hijau (Camellia sinensis) mengandung senyawa bioaktif seperti epigallocatechin gallate (EGCG) dan flavonoid yang berpotensi mengurangi kadar asam urat dengan cara menghambat aktivitas enzim xanthine oxidase. Tujuan Penelitian : Menganalisis efek konsumsi teh hijau terhadap kadar asam urat pada individu dengan hiperurisemia. Metode Penelitian : Penelitian pre-exsperimental dengan cara one group pre-test post-test pada 30 responden hiperurisemia di Wilayah Kerja Puskesmas Gunungsari. Intervensi teh hijau dilakukan selama 14 hari, data dianalisis menggunakan uji statistik paired sample t-test. Hasil Penelitian: Rerata kadar asam urat sebelum pemberian teh hijau sebesar 8,00 mg/dL dan sesudah pemberian teh hijau sebesar 6,88 mg/dL. Berdasarkan uji statistik paired sample t-test didapatkan nilai signifikan 0,000 (p<0,05). Kesimpulan : Terdapat pengaruh yang signifikan pada pemberian teh hijau terhadap kadar asam urat pada penderita hiperurisemia.  
Comparison of Serum Creatinine Levels in Cervical Cancer Patients Receiving Cisplatin-Based and Non-Cisplatin-Based Chemotherapy at NTB Provincial General Hospital Kadek Vera Ardiani; Ari Khusuma; Thomas Tandi Manu; Lalu Srigede
Media Informasi Vol. 22 No. 2 (2026): June
Publisher : Poltekkes Kemenkes Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37160/mijournal.v22i2.1449

Abstract

Background: Cervical cancer is one of the leading causes of morbidity and mortality among women worldwide. Cisplatin-based chemotherapy is widely used because of its effectiveness in inhibiting tumor cell growth. However, its clinical use is limited by nephrotoxicity, which can lead to impaired renal function. Serum creatinine is a key laboratory parameter routinely used to assess kidney function during chemotherapy. Objectives: This study aimed to compare serum creatinine levels between cervical cancer patients receiving cisplatin-based chemotherapy and those treated with non-cisplatin regimens at the Regional General Hospital of West Nusa Tenggara Province. Methods: This analytical observational study employed a cross-sectional design using retrospective medical record and laboratory data. Subjects meeting the inclusion criteria were selected through total sampling. Data were analyzed descriptively and compared using the Mann–Whitney U test because the data were not normally distributed. Statistical significance was set at p<0.05. Results: Serum creatinine levels in the cisplatin group ranged from 0.20 to 4.10 mg/dL, with a mean of 1.60 mg/dL. In the non-cisplatin group, levels ranged from 0.50 to 3.10 mg/dL, with a mean of 0.91 mg/dL. The Mann–Whitney U test showed a statistically significant difference between the two groups (p=0.030). Conclusion: Cervical cancer patients receiving cisplatin-based chemotherapy had significantly higher serum creatinine levels than those receiving non-cisplatin regimens. These findings emphasize the importance of regular renal function monitoring to detect nephrotoxicity and support safe chemotherapy management
Association Between Blood Glucose Levels and Platelet Indices in Patients with Type 2 Diabetes Mellitus Thomas Tandi Manu; Ida Bagus Rai Wiadnya; I wayan Getas
Indonesian Health Issue Vol. 5 No. 2 (2026): AUGUST
Publisher : Indonesian Journal Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47134/inhis.v5i2.214

Abstract

Background: Platelet activity in diabetes mellitus is a concern because platelets play a role in thrombus formation and atherothrombosis. Platelet activity can be assessed through platelet indices, which include the Mean Platelet Volume (MPV), Platelet Distribution Width (PDW), Plateletcrit (PCT), and Platelet Large Cell Ratio (P-LCR), providing an indirect reflection of platelet characteristics. Changes in these parameters may be associated with an increased risk of cardiovascular complications in patients with diabetes mellitus. Objective: This study aims to evaluate platelet activity and analyze its relationship with blood glucose levels in patients with diabetes mellitus. Methods: This study employed an analytical observational design with a cross-sectional approach. The sample consisted of 50 patients with type 2 diabetes mellitus participating in the Chronic Disease Management Program (Prolanis) at the Praya Community Health Center, selected through purposive sampling. Data on blood glucose levels and platelet indices were analyzed using Pearson’s correlation test. Results: The examination results showed a mean blood glucose level of 148.42 mg/dL. Meanwhile, the mean platelet indices were as follows: PDW 16.1%; MPV 9.59 fL; P-LCR 24.43%; and PCT 2.6 mL/L. The results of the Pearson correlation test showed that blood glucose levels were correlated with PDW (r = 0.131; p = 0.364), PCT (r = 0.148; p= 0.305), P-LCR (r = 0.213; p=0.138), and MPV (r=0.182; p=0.206). Conclusion: Platelet indices in patients with diabetes mellitus were generally within the normal range. Blood glucose levels showed a tendency toward a positive correlation with platelet indices, but no  statistically significant relationship was found
Relationship Between Serum Albumin Levels an Troponin I Levels as Markers Of Myocardial Infarction in Heart Patients at RSUD Patut Patuh Patju Para Fauzana Antika; Siti Zaetun; Thomas Tandi Manu; Rohmi
Jurnal Analis Medika Biosains (JAMBS) Vol. 13 No. 02 (2026): JURNAL ANALIS MEDIKA BIOSAINS (JAMBS)
Publisher : Poltekkes Kemenkes Mataram

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Abstract

Troponin I serves as a highly specific biomarker for assessing myocardial damage, whereas serum albumin levels reflect the nutritional, inflammatory, and systemic condition of patients. A decline in serum albumin concentrations is known to correlate with increased severity of cardiovascular disease. This study aimed to investigate the relationship between serum albumin levels and Troponin I levels as markers of myocardial infarction in cardiac patients at RSUD Patut Patuh Patju. An analytical observational study with a cross-sectional design was conducted. Sampling was executed using a purposive sampling technique, analyzing 75 medical records of heart disease patients who underwent serum albumin and Troponin I testing at RSUD Patut Patuh Patju between 2022 and 2025. Data analysis was performed using the Spearman Rank correlation test at a significance level of . The mean serum albumin level was with a minimum value of and a maximum of . The mean Troponin I level was with a range from to . The Spearman Rank correlation test yielded a probability value of (). There is a statistically significant relationship between serum albumin levels and Troponin I levels as a marker of myocardial infarction in heart disease patients at RSUD Patut Patuh Patju.
Optimization Of Brown Rice Flour (Oryza Sativa L.) As An Alternative Medium For The Growth Of Staphylococcus Aureus Bacteria Adhela Gladis Adisti; Siti Zaetun; Thomas Tandi Manu; Rohmi
Journal of Indonesia Laboratory Students (JILTS) Vol. 5 No. 2 (2026): Journal of Indonesia Laboratory Students
Publisher : Poltekkes Kemenkes Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32807/jilts.v5i2.465

Abstract

Background: The high dependence of microbiology laboratories on commercial media like Nutrient Agar (NA), which uses imported components (peptone and meat extract), highlights the need to explore local, cost-effective substrates. Red rice (Oryza sativa L.) is rich in complex carbohydrates, proteins, B-complex vitamins, and micronutrients that could potentially support microbial nutritional needs. Research Methods: An in vitro experimental approach with a post-treatment control scheme was employed in this study. The growth media derived from red rice flour was formulated across four gradient levels: 2.5%, 5.0%, 7.5%, and 10.0% (w/v), supplemented with 1.5% agar matrix, then compared with a positive control NA. S. aureus cultures were inoculated and incubated at 37°C for 24–48 hours. Growth parameters were evaluated descriptively based on colony density and thickness. Research Results: S. aureus can grow under all treatment variations. A 2.5% concentration results in limited growth, 5% and 7.5% concentrations show moderate growth, while a 10% concentration shows very dense and abundant colonies, comparable on a macroscopic level to standard NA media (fertility score 3). Conclusion: Red rice flour has proven to be potentially used as a base material for bacterial inoculum, with a 10% concentration being the most optimal for producing S. aureus growth equivalent to standard media.
Inhibition Test of Honey Mango Leaf Extract (Mangivera Indica L.) against the Growth of Aspergillus flavus Lestari Febriani; I Wayan Getas; Thomas Tandi Manu; Erna Kristinawati
Journal of Indonesia Laboratory Students (JILTS) Vol. 5 No. 2 (2026): Journal of Indonesia Laboratory Students
Publisher : Poltekkes Kemenkes Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32807/jilts.v5i2.466

Abstract

Background: Aspergillus flavus is a dangerous pathogenic contaminant in agricultural commodities capable of producing highly carcinogenic aflatoxins. The escalation of resistance against synthetic chemical antifungals necessitates the discovery of safer natural alternatives. Honey mango leaves (Mangifera indica L. var. madu) accumulate potent secondary metabolites including flavonoids, tannins, saponins, alkaloids, and phenolics that manifest high antimicrobial properties. Objective: To determine the inhibitory effect of honey mango leaf (Mangifera indica L.) extract at concentrations of 80%, 70%, 60%, 50%, 40%, 30%, and 20% on the growth of Aspergillus flavus. Research Methods: This laboratory experimental design employed the disc diffusion technique using seven concentration levels (80%, 70%, 60%, 50%, 40%, 30%, and 20%) with triplicated observations. The primary metric recorded was the diameter of the inhibition zone around the paper discs. Research Results: The organic extract significantly restricted the proliferation of Aspergillus flavus across all tested ranges. The mean diameter of inhibition zones for concentrations of 80%, 70%, 60%, 50%, 40%, 30%, and 20% were measured at 39.3 mm, 33.7 mm, 31.3 mm, 26.0 mm, 24.7 mm, 20.7 mm, and 17.0 mm, respectively. Statistical trends confirmed that the inhibition area expands proportionally with the increase of extract dose. Conclusion: Honey mango leaf extract exhibits robust antifungal activities. A concentration of 50% represents the optimum threshold, yielding an inhibitory zone of 26.0 mm which demonstrates clinical parity with the commercial positive control group.
Co-Authors Adhela Gladis Adisti Ari Khusuma Dewi, Lale Budi Kusuma Erna Kristinawati Febriyanti Rizki Diana Lestari Diana Hikmatul Lailli I Wayan Getas Kadek Vera Ardiani Lalu Srigede Lestari Febriani Lisda Ramadhania Muhammad Haerunnizam Pancawati Ariami Para Fauzana Antika RAI WIADNYA, IDA BAGUS Rohmi Siti zaetun