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All Journal Meditory : The Journal of Medical Laboratory Jurnal Analis Medika Biosains (JAMBS) Media Informasi Jurnal Teknologi Laboratorium Medik Borneo Journal of Indonesia Laboratory Students (JILTS)
Thomas Tandi Manu
Poltekkes Kemenkes Mataram
Biochemistry, Genetics & Molecular Biology Dentistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Differences In Creatinine Levels And Reticulocyte Values In CKD Patients Undergoing Epo And Non-Epo Therapy Thomas Tandi Manu; Hikmatul Lailli; I Wayan Getas
Jurnal Analis Medika Biosains (JAMBS) Vol. 13 No. 01 (2026): JURNAL ANALIS MEDIKA BIOSAINS (JAMBS)
Publisher : Poltekkes Kemenkes Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Chronic kidney disease (CKD) is a condition of progressive and irreversible decline in kidney function. One of the main complications of CKD is anemia, caused by decreased erythropoietin (Epo) production by the kidneys. Epodi therapy is used to stimulate red blood cell production. Reticulocyte counts are used as an indicator of erythropoietic activity, while creatinine levels reflect the degree of kidney damage To determine the differences in creatinine levels and reticulocyte values between CKD patients undergoing Epo and non-Epo therapy.This study was a quantitative cross-sectional study. The sample consisted of 60 CKD patients, divided into two groups: 30 patients with Epo therapy and 30 patients without Epo therapy. Data were collected through medical records and analyzed using the independent T-test. The average creatinine level in the Epo group was 3.96 mg/dL, while in the Non Epo group it was 1.83 mg/dL. The average reticulocyte value in the Epo group was 0.64%, while in the Non Epo group it was 1.49%. The results of the independent T test statistical test obtained a P value of creatinine levels of 0.000_
Test Screening Hepatitis A dan Hepatitis B pada Masyarakat Di Wilayah Kerja Puskesmas Alas Barat Febriyanti Rizki Diana Lestari Diana; Rohmi; Thomas Tandi Manu; Siti Zaetun
Journal of Indonesia Laboratory Students (JILTS) Vol. 5 No. 1 (2026): Journal of Indonesia Laboratory Students
Publisher : Poltekkes Kemenkes Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32807/jilts.v5i1.91

Abstract

Latar Belakang: Test screening HAVAg dan HbsAg merupakan pemeriksaan untuk mendeteksi dini infeksi virus hepatitis A dan hepatitis B pada seseorang. Hepatitis sendiri merupakan penyakit peradangan pada hati yang dapat sembuh dengan sendirinya atau berkembang menjadi fibrosis (jaringan parut), sirosis, atau kanker hati. Wilayah Alas Barat masih menjadi wilayah yang memiliki angka infeksi hepatitis yang tinggi serta rendahnya informasi tentang hepatitis dan akses pelayanan laboratorium penanganan kasus hepatitis pada masyarakat sebagai latar belakang masalah. Tujuan Penelitian: Untuk menganalisis dan mengetahui hasil test screening Hepatitis A dan Hepatitis B pada Masyarakat yang terkena infeksi Hepatitis A dan Hepatitis B. Metode Penelitian: Metode yang digunakan dalam penelitian ini adalah secara deskriptif kualitatif dengan menggunakan pengumpulan data yaitu data primer dan sekunder. Hasil: Test screening pada Hepatitis A menunjukkan bahwa 20 sampel yang telah dilakukan test screening di dapatkan hasil Non-Reaktif/Negatif Hepatitis A (HAVag), sedangkan pada Hepatitis B di dapatkan hasil dari 80 sampel yang telah dilakukan test screening 20 sampel di antaranya menunjukkan hasil Reaktif/Positif Hepatitis B (HbsAg). Kesimpulan: Di wilayah Alas Barat tidak ditemukan virus Hepatitis A dan pada Hepatitis B ditemukan sekitar 25% penduduk Alas Barat terkena infeksi virus Hepatitis B.
THE EFFECT OF CHEMOTHERAPY ON BLOOD CELL COUNTS IN POST-MASTECTOMY BREAST CANCER PATIENTS Muhammad Haerunnizam; Pancawati Ariami; Thomas Tandi Manu; Lale Budi Kusuma Dewi
Meditory : The Journal of Medical Laboratory Vol. 13 No. 2 (2025): Meditory, Volume 13 No. 2 Tahun 2025
Publisher : Jurusan Teknologi Laboratorium Medis, Poltekkes Kemenkes Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33992/meditory.v13i2.4096

Abstract

Background: Post-mastectomy chemotherapy often causes myelosuppression, as do the numbers of erythrocytes, leukocytes, and platelets.Objective: To determine the effect of chemotherapy on the number of blood cells in post-mastectomy breast cancer patients.Methods: This study was a retrospective observational study. The population in the study was breast cancer patients who underwent chemotherapy  0 (Pre-chemotherapy) to 4 times after mastectomy at the NTB Provincial Hospital from January to December 2024. Sampling was done using non-probability sampling with a purposive sampling method, resulting in 68 samples.Results: In the study, the average number of erythrocytes from session 0 (Pre-chemotherapy) to session 4 was 4,23; 3,80; 3,67; 3,59, and 3,6 million cells/µL. Then, the average number of leukocytes from session 0 (Pre-chemotherapy) to session 4 was 7,208; 5,024; 4,739; 3,690, and 3,281 thousand cells/µL. Meanwhile, the average number of platelets from session 0 (Pre-chemotherapy) to session 4 was 386,251; 302,792; 275,760; 228,014, and 206,035 thousand cells/µL. Based on the Friedman test data analysis, the results showed a significance value of 0.001 < 0.05.Conclusions: There is an effect of chemotherapy on the number of blood cells in post-mastectomy breast cancer patients.
Pengaruh Pemberian Teh Hijau (Camellia Sinensis) Terhadap Kadar Asam Urat Pada Penderita Hiperurisemia Lisda Ramadhania; Lalu Srigede; Thomas Tandi Manu; I Wayan Getas
Jurnal Teknologi Laboratorium Medik Borneo Vol. 5 No. 2 (2025): Jurnal Teknologi Laboratorium Medik Borneo
Publisher : Institut Teknologi Kesehatan dan Sains Wiyata Husada Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35728/jutelmo.v5i2.2005

Abstract

Latar Belakang : Hiperurisemia adalah keadaan meningkatnya kadar asam urat dalam darah yang berpotensi menimbulkan komplikasi berupa gout artritis maupun gangguan kardiovaskular. Teh hijau (Camellia sinensis) mengandung senyawa bioaktif seperti epigallocatechin gallate (EGCG) dan flavonoid yang berpotensi mengurangi kadar asam urat dengan cara menghambat aktivitas enzim xanthine oxidase. Tujuan Penelitian : Menganalisis efek konsumsi teh hijau terhadap kadar asam urat pada individu dengan hiperurisemia. Metode Penelitian : Penelitian pre-exsperimental dengan cara one group pre-test post-test pada 30 responden hiperurisemia di Wilayah Kerja Puskesmas Gunungsari. Intervensi teh hijau dilakukan selama 14 hari, data dianalisis menggunakan uji statistik paired sample t-test. Hasil Penelitian: Rerata kadar asam urat sebelum pemberian teh hijau sebesar 8,00 mg/dL dan sesudah pemberian teh hijau sebesar 6,88 mg/dL. Berdasarkan uji statistik paired sample t-test didapatkan nilai signifikan 0,000 (p<0,05). Kesimpulan : Terdapat pengaruh yang signifikan pada pemberian teh hijau terhadap kadar asam urat pada penderita hiperurisemia.  
Comparison of Serum Creatinine Levels in Cervical Cancer Patients Receiving Cisplatin-Based and Non-Cisplatin-Based Chemotherapy at NTB Provincial General Hospital Kadek Vera Ardiani; Ari Khusuma; Thomas Tandi Manu; Lalu Srigede
Media Informasi Vol. 22 No. 2 (2026): June
Publisher : Poltekkes Kemenkes Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37160/mijournal.v22i2.1449

Abstract

Background: Cervical cancer is one of the leading causes of morbidity and mortality among women worldwide. Cisplatin-based chemotherapy is widely used because of its effectiveness in inhibiting tumor cell growth. However, its clinical use is limited by nephrotoxicity, which can lead to impaired renal function. Serum creatinine is a key laboratory parameter routinely used to assess kidney function during chemotherapy. Objectives: This study aimed to compare serum creatinine levels between cervical cancer patients receiving cisplatin-based chemotherapy and those treated with non-cisplatin regimens at the Regional General Hospital of West Nusa Tenggara Province. Methods: This analytical observational study employed a cross-sectional design using retrospective medical record and laboratory data. Subjects meeting the inclusion criteria were selected through total sampling. Data were analyzed descriptively and compared using the Mann–Whitney U test because the data were not normally distributed. Statistical significance was set at p<0.05. Results: Serum creatinine levels in the cisplatin group ranged from 0.20 to 4.10 mg/dL, with a mean of 1.60 mg/dL. In the non-cisplatin group, levels ranged from 0.50 to 3.10 mg/dL, with a mean of 0.91 mg/dL. The Mann–Whitney U test showed a statistically significant difference between the two groups (p=0.030). Conclusion: Cervical cancer patients receiving cisplatin-based chemotherapy had significantly higher serum creatinine levels than those receiving non-cisplatin regimens. These findings emphasize the importance of regular renal function monitoring to detect nephrotoxicity and support safe chemotherapy management
Co-Authors Ari Khusuma Dewi, Lale Budi Kusuma Febriyanti Rizki Diana Lestari Diana Hikmatul Lailli I Wayan Getas Kadek Vera Ardiani Lalu Srigede Lisda Ramadhania Muhammad Haerunnizam Pancawati Ariami Rohmi Siti zaetun