Adolescents are vulnerable to the long-term effects of anemia, ranging from impaired physical growth and reduced cognitive capacity for learning to risks regarding reproductive health. Therefore, interventions aimed at meeting iron requirements through the consumption of Iron-Folic Acid (IFA) tablets must be prioritized as a preventive strategy. However, successful implementation requires adequate knowledge regarding the benefits and proper usage of these tablets. This study aimed to assess changes in adolescent knowledge regarding anemia prevention following an educational intervention using leaflets in Karangreja Village, Maos District, Cilacap Regency. The study involved 50 adolescents selected via purposive sampling and employed a one-group pretest-posttest design. Knowledge levels were measured using a questionnaire administered both before and after the educational session. The collected data were analyzed using the Wilcoxon Signed-Rank test at a significance level of 0.05. The findings revealed an increase in the average knowledge score from 61.4 to 84.7 following the intervention. Prior to the intervention, the majority of respondents (56%) possessed a "sufficient" level of knowledge, while 30% fell into the "poor" category. This situation changed significantly after the intervention, with the proportion of respondents demonstrating "good" knowledge rising to 82%. The p-value of 0.000 (p < 0.05) obtained from the Wilcoxon test provides strong evidence that the educational intervention significantly improved the respondents' knowledge. These results confirm the effectiveness of leaflets as a health education medium for fostering adolescent understanding of anemia prevention and the importance of consuming IFA tablets.
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