<![CDATA[Exposure to free radicals and UV radiation can damage the skin, requiring a preparation with antioxidant activity and UV protection. Bitter melon (Momordica charantia L.) contains flavonoid and phenolic compounds with antioxidant potential. Objective: This study determined the physical stability, antioxidant activity, and SPF value of bitter melon extract serum in vitro. Methods: Bitter melon fruit was extracted by maceration with 70% ethanol and formulated into four formulas: F0 (base) and F1, F2, F3 (extract concentrations 2%, 4%, 6%). Physical quality (organoleptic properties, homogeneity, pH, viscosity, adhesion) was evaluated, followed by an accelerated cycling test for six cycles. Antioxidant activity was determined using DPPH with IC50 from linear regression, and SPF was determined using UV-Vis spectrophotometry (Mansur method, 290-320 nm). Results: All formulas met physical quality requirements and remained homogeneous after stability testing. IC50 values of F0-F3 were 112.64, 50.45, 43.37, and 41.38 ppm, compared with quercetin (26.84 ppm) and a commercial serum control (26.04 ppm). SPF values were 5.33, 7.552, 8.174, and 8.373, respectively. Conclusion: Bitter melon extract serum can be formulated as a physically stable preparation with antioxidant activity and UV protection, with F3 showing the highest antioxidant activity and SPF value.]]>
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