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All Journal Journal of Educational Innovation and Public Health Journal of Innovative and Creativity Galen: Jurnal Ilmu Farmasi dan Kesehatan Borneo Nursing Journal
Siwi Hastuti
Universitas Duta Bangsa Surakarta
Dentistry Education Health Professions Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Aktivitas Tonikum Infusa Bunga Telang (Clitoria ternatea L.) terhadap Mencit dengan Metode Natatory Exhaustion dan Induksi Tidur Eli Yuliana. H; Siwi Hastuti; Rahmat Hidayat
Journal of Innovative and Creativity Vol. 6 No. 1 (2026)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/joecy.v6i1.8214

Abstract

ABSTRACT Tonics are agents that can stimulate body activity, thereby delaying feelings of fatigue, lethargy, and exhaustion. This study aimed to determine the ability of butterfly pea flower infusion to increase swimming time and its potential effect on the sleep duration of mice, as well as to evaluate the relationship between dose variation and tonic effects. Butterfly pea flower contains secondary metabolites such as alkaloids and flavonoids, which are known to produce tonic effects. This experimental study used 25 mice as test animals, divided into five groups. The test groups consisted of a negative control (distilled water), a positive control (caffeine 100 mg), and butterfly pea flower infusion at doses of 10%, 20%, and 40%. The results showed that butterfly pea flower infusion exhibited tonic effects in both the natatory exhaustion and sleep induction methods. The 10% dose produced tonic effects of 38.99% ± 10.34% in the natatory exhaustion method and 17.72% ± 6.13% in the sleep induction method. The 20% dose resulted in tonic effects of 52.82% ± 7.39% and 39.38% ± 6.22%, respectively. The 40% dose produced the greatest tonic effect, with values of 79.53% ± 3.82% in the natatory exhaustion method and 59.55% ± 1.72% in the sleep induction method. Keywords: Butterfly Pea Flower, Infusion, Natatory Exhaustion, Sleep Induction, Tonic
Formulasi dan Uji Aktivitas Antioksidan Face Toner Ekstrak Etanol Daun Yakon (Smallanthus sonchifolius) Menggunakan Metode DPPH Fika Riyanti; Bagas Ardiyantoro; Siwi Hastuti
Journal of Innovative and Creativity Vol. 6 No. 1 (2026)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

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Abstract

Excessive exposure to sunlight can cause the formation of free radicals that can damage skin tissue, thus requiring natural antioxidants. The use of natural ingredients as a source of antioxidants in the form of topical preparations is a potential alternative. This study aims to formulate ethanol extract of yakon leaves (Smallanthus sonchifolius) into a face toner formulation and evaluate its physical quality, antioxidant activity, and to determine the optimal concentration of the face toner formulation that can inhibit free radicals. Extraction was carried out using the maceration method with 70% ethanol, then formulated into face toner with different concentrations, namely 1%, 2%, and 3%. After that, physical quality evaluation was carried out in the form of organoleptic tests, pH tests, homogeneity tests, and viscosity tests. Antioxidant activity was tested using the DPPH method and measured using UV-Vis spectroscopy at a wavelength of 520 nm. The results showed that all formulas met the physical quality test standards and had antioxidant activity at concentrations of 1%, 2%, and 3% with IC50 values of 95.91, 93.58, and 91.70, respectively, all of which were classified as strong. while the negative control formula without extract had a value of 167 (weak category), and the positive control quercetin had a value of 9.95 (very strong category).
Uji Efektivitas Sediaan Krim Ekstrak Etanol Daun Bidara (Ziziphus Mauritiana L.) terhadap Penyembuhan Luka Bakar pada Kelinci New Zealand Romio Carlos Lopo Dos Reis; Siwi Hastuti; Septian Maulid Wicahyo
Borneo Nursing Journal (BNJ) Vol. 8 No. 2b (2026)
Publisher : Akademi Keperawatan Yarsi Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61878/bnj.v8i2b.1461

Abstract

Luka bakar merupakan cedera pada jaringan kulit akibat paparan panas, bahan kimia, listrik, maupun radiasi yang memerlukan penanganan yang tepat untuk mempercepat proses penyembuhan dan mencegah terjadinya infeksi. Daun bidara (Ziziphus Mauritiana L.) mengadung senyawa metabolit, sekunder, seperti flavonoid, alkaloid, tanin, dan saponin, yang memiliki aktivitas antioksidan, antiinflamasi, serta antibakteri sehingga berpotensi mempercepat penyembuhan luka. Penelitian ini bertujuan untuk mengetahui efektivitas sediaan krim ekstrak etanol daun bidara terhadap penyembuhan luka bakar pada kelinci New Zealand serta menentukan konsentrasi ekstrak yang paling efektif. Penelitian ini merupakan penelitian eksperimental menggunakan empat ekor kelinci New Zealand sebagai hewan uji. Ekstrak daun bidara diperoleh melalui metode maserasi menggunakan etanol 70% dan diformulasikan dalam sediaan krim tipe air dalam minyak (A/M) dengan konsentrasi ekstrak 5% (F1), 10% (F2), dan 15% (F3). Betadine Antiseptic Ointment digunakan sebagai kontrol positif, sedangkan basis krim digunakan sebagai kontrol negatif. Pengobatan dilakukan selama 14 Hari dengan frekuensi dua kali sehari. Efektivitas penyembuhan luka dievaluasi berdasarkan nilai Area Under Curve (AUC) dan persentase daya penyembuhan luka (%DPL). Data dianalisis menggunakan uji One-Way ANOVA dan Least Significant Difference (LSD). Penelitian menunjukkan bahwa seluruh formula memenuhi persyaratan mutu fisik sediaan krim. Formula F3 (15%) memberikan efektivitas terbaik dengan nilai AUC 12,9950 ± 0,01 dan %DPL (25,78527)%, mendekati kontrol positif yang memiliki nilai AUC 12,5125 ± 0,01 dan %DPL (28,54083)%. Uji One-Way ANOVA menunjukkan adanya perbedaan yang signifikan antar kelompok perlakuan (p < 0,05), sedangkan uji LSD menunjukkan seluruh kelompok berbeda signifikan. Berdasarkan hasil dapat disimpulkan bahwa krim ekstrak etanol daun bidara efektivitas mempercepat penyembuhan luka bakar pada kelinci New Zealand, dengan konsentrasi ekstrak 15% sebagai formula yang paling efektif.
Formulasi dan Uji Aktivitas Antiskabies Krim Ekstrak Etanol Daun Kemangi (Ocimum sanctum L.) pada Kelinci Murni Widiati; Siwi Hastuti; Septian Maulid Wicahyo
Galen: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 2 (2026): Galen: Jurnal Riset Ilmu Farmasi dan Kesehatan Bulan Oktober
Publisher : PT Pustaka Cendekia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71417/galen.v2i2.308

Abstract

Latar Belakang: Daun kemangi (Ocimum sanctum L.) mengandung eugenol yang berpotensi sebagai akarisida alami untuk mengatasi skabies. Tujuan: Memformulasi ekstrak etanol daun kemangi menjadi sediaan krim, mengevaluasi mutu fisiknya, serta menguji efektivitas antiskabiesnya pada kelinci dibandingkan dengan Permetrin 5%. Metode: Ekstrak dibuat secara maserasi dan diformulasikan ke dalam krim dengan variasi konsentrasi: F0 (0%), F1 (10%), F2 (15%), dan F3 (25%). Evaluasi sediaan meliputi uji organoleptis, pH, viskositas, daya sebar, dan daya lekat. Uji efektivitas dilakukan secara in vivo pada kelinci dengan parameter luas keropeng yang dianalisis menggunakan metode AUC dan uji Independent Sample T-Test. Hasil: Variasi konsentrasi ekstrak memengaruhi sifat fisik sediaan; peningkatan konsentrasi menurunkan pH dan viskositas. Formula F3 (25%) merupakan formula dengan mutu fisik terbaik karena memenuhi semua standar fisik dan memiliki daya sebar tertinggi (6,47 cm). Hasil uji in vivo menunjukkan krim F3 (25%) mampu menyembuhkan skabies total pada hari ke-7, di mana analisis statistik nilai AUC membuktikan efektivitasnya tidak berbeda signifikan (sig. = 0,721; p > 0,05) dengan Permetrin 5%. Kesimpulan: Krim ekstrak etanol daun kemangi 25% (F3) memiliki karakteristik mutu fisik terbaik dan memiliki efektivitas antiskabies yang setara dengan kontrol positif Permetrin 5%.
Formulasi dan Uji Stabilitas Sediaan Serum Ekstrak Buah Pare (Momordica Charantia L.) dengan Aktivitas Antioksidan Metode DPPH Serta Penentuan Nilai SPF Berlyana Artia Fatikah; Siwi Hastuti; Septian Maulid Wicahyo
Journal of Educational Innovation and Public Health Vol. 4 No. 4 (2026): Oktober : Journal of Educational Innovation and Public Health
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/innovation.v4i4.10543

Abstract

Exposure to free radicals and UV radiation can damage the skin, requiring a preparation with antioxidant activity and UV protection. Bitter melon (Momordica charantia L.) contains flavonoid and phenolic compounds with antioxidant potential. Objective: This study determined the physical stability, antioxidant activity, and SPF value of bitter melon extract serum in vitro. Methods: Bitter melon fruit was extracted by maceration with 70% ethanol and formulated into four formulas: F0 (base) and F1, F2, F3 (extract concentrations 2%, 4%, 6%). Physical quality (organoleptic properties, homogeneity, pH, viscosity, adhesion) was evaluated, followed by an accelerated cycling test for six cycles. Antioxidant activity was determined using DPPH with IC50 from linear regression, and SPF was determined using UV-Vis spectrophotometry (Mansur method, 290-320 nm). Results: All formulas met physical quality requirements and remained homogeneous after stability testing. IC50 values of F0-F3 were 112.64, 50.45, 43.37, and 41.38 ppm, compared with quercetin (26.84 ppm) and a commercial serum control (26.04 ppm). SPF values were 5.33, 7.552, 8.174, and 8.373, respectively. Conclusion: Bitter melon extract serum can be formulated as a physically stable preparation with antioxidant activity and UV protection, with F3 showing the highest antioxidant activity and SPF value.
Co-Authors Bagas Ardiyantoro Berlyana Artia Fatikah Eli Yuliana. H Fika Riyanti Murni Widiati Rahmat Hidayat Romio Carlos Lopo Dos Reis Septian Maulid Wicahyo