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All Journal Duta Pharma Journal International Journal of Health, Engineering and Technology
Septian Maulid Wicahyo
Universitas Duta Bangsa Surakarta
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Mechanical Engineering Medicine & Pharmacology Nursing Public Health Veterinary

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Analysis of The Relationship Between Polypharmacy and Potentially Inappropriate Medications (PIMs) Based on The 2023 Beers Criteria in Geriatric Diabetes Mellitus Patients Oktavian Asyon Herlambang; Aprilia Puteri Santika; Septian Maulid Wicahyo
Duta Pharma Journal Vol. 6 No. 1 (2026): Duta Pharma Journal
Publisher : Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/pqjb4t96

Abstract

Background: Diabetes mellitus can cause various complications if it is not controlled, resulting in the risk of increasing the number drugs prescribed. The number of medications is one factor that can describe the incidence of Potentially Inappropriate Medications (PIMs). Objectives: This Research is to determine the percentage of PIMs based on the Beers Criteria 2023 and to determine the relationship between the number of drug prescriptions and the incidence of PIMs. Methods: used is descriptive observational. A sample of 120 recipes was carried out using purposive sampling which met the inclusion criteria. Data analysis using the chi square test and correlative contingency coefficient test. Results: the research showed that the demographic characteristics of geriatric diabetes mellitus patients at RSU Asy Syifa' Sambi Boyolali for the period January-March 2025 were dominated by female patients of 76 patients (63.33%), the majority aged 60-69 years, namely 83 patients (69.17%), the number of drugs ? 5 namely of  78 patients (65%), and 114 patients (95%) had comorbidities.There is a percentage of PIMs in the amount of 32.24% of the total drug items, the highest number of PIMs is category 2, namely 32.49%. Based on the results of statistical tests, it shows a p-value of 0.217 (p > 0.05), which means there is no statistically significant relationship between the amount of medication and the incidence of PIMs. Apart from that, the correlation coefficient value for the two variables is 0.112, indicating that the level of strength of the relationship is in the very weak category. Conclusion: An increasing the number of prescribed medications is not the only factor contributing to PIMs. The association between polypharmacy and PIM was not statistically significant (p=0.217) and showed a very weak value. These findings emphasize that in geriatric diabetes care, quality prescribing, appropriate management of complex comorbidities, and regular clinical monitoring effectively reduce the risk of polypharmacy. Therefore, evaluating the appropriateness of therapy is far more important than simply limiting the number of medications.
Design Of New Compounds Derived From Rosella Flavonoids As Diabetes Mellitus Enzyme Inhibitors Using Computer-Aided Drug Design Strategy Oktavia Nanda lestari; Tiara Ajeng Litsyani; Septian Maulid Wicahyo
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.603

Abstract

Type 2 diabetes mellitus is increasing rapidly in Indonesia with a projected prevalence of 16.09% in 2045, requiring local plant-based α-amylase and α-glucosidase enzyme inhibitors such as the flavonoid kaempferol-3-O-rutinoside from roselle flowers (Hibiscus sabdariffa L.), which shows potential in silico inhibition but suboptimal ADMETox profile. This in silico computational experimental study aims to design kaempferol-3-O-rutinoside derivative compounds as effective inhibitors through computer-aided drug design, with a population of parent compounds, target enzymes, and acarbose as controls; purposive samples in the form of substituent modifications; PyRx-AutoDock Vina, SwissADME, Toxtree instruments; and molecular docking analysis techniques (ΔG, RMSD) and ADMETox prediction. The results showed a new compound with ΔGbind -5.0 kcal/mol (α-amylase, RMSD 1.538), -5.2 kcal/mol (α-glucosidase, RMSD 2.08), similarity of residues Asn A 570, Asp A 243, Val A 867, high GI absorption (molecular weight 340.41 g/mol, LogP 0.06), and low class I toxicity. In conclusion, the new compound has the potential as a safe oral antidiabetic drug candidate, in vitro/in vivo validation is recommended for further development
Determination Of Sun Protection Factor (SPF) Values Of Water, Ethyl Acetate, And N-Hexane Fractions Of Kepok Banana Flowers (Musa acuminata x M. balbisiana) Using The UV-Vis Spectrophotometry Method Evi Eriani; Septian Maulid Wicahyo; Tatiana Siska Wardani
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.636

Abstract

Indonesia as a tropical country faces high UV exposure which causes premature skin aging and cancer risk, so it is necessary to have natural sunscreen from antioxidant-rich plants such as kepok banana flowers (Musa acuminata x M. balbisiana). This study aims to determine the Sun Protection Factor (SPF) value and protection category of water, ethyl acetate, and n-hexane fractions of kepok banana flowers. This type of research is descriptive experimental with ethanol maceration method, multilevel fractionation, phytochemical screening, TLC, and UV-Vis spectrophotometry (290-320 nm, Mansur formula).The results showed that the different types of solvents in each fraction influenced the resulting SPF value. The ethyl acetate fraction showed the highest protective activity compared to the other fractions. The SPF values ​​of the kepok banana flower water fraction with concentrations of 60 ppm, 80 ppm, 100 ppm, 120 ppm, and 140 ppm were 4.662; 7.757; 9.055; 11.944; 15.264, respectively, with moderate-ultra protection. The ethyl acetate fraction obtained SPF values ​​of 18.433; 18.968; 19.203; 19.672; 20.203 with ultra protection. The n-hexane fraction obtained SPF values ​​of 1.190; 1.762; 2.278; 3.575; 4.598 with the category of no-moderate protection.. Concludedthat kepok banana flowers have potential as a natural sunscreen agent, where the ethyl acetate and water fractions provide the most optimal sun protection effectiveness (SPF) compared to the n-hexane fraction.
Co-Authors Aprilia Puteri Santika Evi Eriani Oktavia Nanda lestari Oktavian Asyon Herlambang Tatiana Siska Wardani Tiara Ajeng Litsyani