<![CDATA[Nephrolithiasis is a urinary tract disorder with increasing prevalence, driving the utilization of natural ingredients such as meniran herb (Phyllanthus niruri L.) as a complementary therapy. This study aims to examine and map the pharmacological potential and main secondary metabolite profile of meniran herb as a complementary therapy for nephrolithiasis based on pharmaceutical e-journals. The research method used was a retrospective descriptive study employing a secondary data approach on a sample of 60 articles from pharmaceutical e-journals publication period April 2021 and May 2026.The results showed that the pharmacological activity profile was dominated by antilithiatic activity reported in 37 articles (61.67%), followed by antioxidant activities in 31 articles (51.67%), and diuretic activity in 15 articles (25.00%). The primary secondary metabolites identified were flavonoids in 32 articles (53.33%), tannins and phenolics in 28 articles (46.67%), alkaloids in 24 articles (40.00%), and lignans (phyllanthin and hypophyllanthin) in 21 articles (35.00%). In conclusion, Meniran Herb exhibits promising pharmacological potential as a complementary therapy for nephrolithiasis through synergistic, multifaceted mechanisms (whole-herb approach) driven by its diverse secondary metabolite constituents.]]>
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