The Role of Curcumin in Reducing Antituberculosis Drug-Induced Hepatotoxicity: A Literature Review

Muhammad Parsha Arvaraby (Universitas Bengkulu)
Maytri Purnama Sari (Universitas Bengkulu)
Namira Qesya Ramadhani Rendra (Universitas Bengkulu)
Rahmah Putri Ayu Lestari (Universitas Bengkulu)
Rosevelt Lethare Sipatuhar (Universitas Bengkulu)
Oktoviani Oktoviani (Universitas Bengkulu)

Locus Journal of Academic Literature Review
Vol 5 No 10 (2026): October

Antituberculosis drug-associated liver injury may interrupt tuberculosis treatment. This structured narrative review examines curcumin as a potential hepatoprotective adjunct while distinguishing mechanistic findings from evidence of clinical benefit. Four focal publications were identified in the documented literature review: one retrospective observational study of Curcuma-tablet use and three secondary reviews. Two underlying experimental reports were additionally traced to clarify the mechanisms discussed in those reviews; they were not counted as independently screened publications. Preclinical findings suggest modulation of oxidative stress and apoptosis, protoporphyrin IX and ferrochelatase, and SIRT1/PGC-1α/NRF1 signaling. A retrospective study involving 60 patients reported lower mean AST, ALT, and bilirubin values associated with a Curcuma preparation, but its design and incompletely characterized formulation do not establish a curcumin-specific treatment effect. Interpretation is limited by overlapping reviews, preclinical evidence, and sparse human data. Curcumin remains a research candidate rather than an established intervention for antituberculosis drug-induced hepatotoxicity. Controlled clinical studies are needed to determine efficacy, dosage, formulation, safety, and potential drug interactions.