<![CDATA[This study aims to determine the effect of red seaweed ( Eucheuma cottonii ) extract and chitosan concentration on the quality of natural mouthwash. Seaweed extract was obtained through a maceration method using 70% ethanol and formulated with variations in seaweed weight of 40–60 grams and chitosan concentration of 0.6–1.4%. The parameters tested included pH, specific gravity, organoleptic, and antioxidant activity. The results showed a pH value ranging from 6.0–6.9, a specific gravity of 1.0716–1.0884 g/mL, and antioxidant activity indicating the potential of red seaweed bioactive compounds. The organoleptic test results showed that the best formulation was obtained with 40 grams of seaweed extract and 0.6% chitosan with the highest level of panelist preference. Based on the results of the study, red seaweed extract and chitosan have the potential to be used as active ingredients in natural mouthwash formulations. Keywords: mouthwash, Eucheuma cottonii, chitosan, antioxidants.]]>
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