<![CDATA[Science is the foundation of modern civilization that develops through rational and structured thinking processes. This paper examines the integrative relationship between science, philosophy of science, and scientific research methods in the context of contemporary scientific development. Using a literature study approach, this study analyzes the dimensions of ontology, epistemology, and axiology as the philosophical basis for scientific development, as well as explores the role of the scientific method as an instrument of scientific truth validation. The results of the study show that scientific research methods based on the philosophy of science produce systematic, objective, and accountable knowledge. Research ethics are an important dimension in maintaining the integrity and usefulness of science for society. In the modern era, the scientific method remains relevant as a systematic approach to dealing with the complexity of global problems, with a significant contribution to the advancement of science through the production of new verified and tested knowledge.]]>
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