This study aimed to develop a Student Worksheet (LKPD) based on the Thinking Empowerment by Questioning (TEQ) learning model on the cell biology topic for grade XI of SMA 2 Sinjai, and to determine its validity, practicality, and effectiveness. The method used was Research and Development (R&D) with the ADDIE model (Analysis, Design, Development, Implementation, Evaluation). The subjects were 30 grade XI students of SMA 2 Sinjai. Data were collected through expert validation sheets, response questionnaires, and learning achievement tests. The results showed that: (1) the LKPD was highly valid with an average score of 3.77; (2) highly practical based on student responses (average 3.32) and teacher responses (average 3.80); and (3) it resulted in 90% class-wide mastery (27 of 30 students achieved the minimum mastery criterion). Therefore, this LKPD is suitable for use in Biology learning as an alternative interactive teaching material.
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