<![CDATA[Diabetes mellitus remains a major global health problem, driving the search for safe and effective natural antidiabetic agents. This quasi-experimental study evaluates the antidiabetic activity of the ethyl acetate fraction of bengkal leaves (Nauclea orientalis L.) and determines the optimal dose in alloxan-induced male mice. Using a completely randomized design, 30 mice were divided into six groups: negative control, positive control (glibenclamide 0.65 mg/kgBW), and treatment groups receiving 150, 300, 450, and 600 mg/kgBW of the ethyl acetate fraction. Blood glucose levels were measured on days 1, 3, and 7 and analyzed using ANOVA and Duncan’s post hoc test. The results show a significant reduction in blood glucose levels (p < 0.001), with the 450 mg/kgBW dose being the most effective, producing a 49.53% decrease on day 7, comparable to the positive control. Higher doses showed lower effectiveness. The study concludes that the ethyl acetate fraction of bengkal leaves has strong antidiabetic activity and potential for development as a phytopharmaceutical candidate for diabetes management.]]>
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