This study aims to analyze the determinants of compliance with OAT in pulmonary tuberculosis patients at the Central Market Health Center. This study used a cross-sectional design involving 158 pulmonary TB patients at the Pasar Sentral Health Center, Mimika Regency, whose samples were taken by a saturated sampling technique. Data analysis was carried out univariate, bivariate (Chi-square and Fisher Exact tests), and multivariate with logistic regression. Bivariate analysis found that age (p = 0.978), gender (p = 0.136), OAT side effects (p = 0.301), and distance to health facilities (p = 0.635) were not significant with adherence to OAT taking. Comorbidity variables were significantly related (p = 0.016; RP = 2,808; 95% CI: 1,445–5,457). Multivariate analysis confirmed comorbidity as a significant factor (p = 0.008; Exp(B) = 5.487), while gender showed a significant tendency (p = 0.058; Exp(B) = 2.428)
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