Drug-resistant tuberculosis is a public health threat because it contributes to the increasing incidence of tuberculosis. The purpose of this study is to determine the risk of the incidence of Drug-Resistant Tuberculosis (TB C RO) in Papua Province. Types of analytical observational research with a cross-sectional approach. The population is 272 people, and the sample is the total population. The secondary data were then analyzed univariately, bivariately with the Chi-Square test, and multivariately using binary logistics. The results of the study found that factors that were significantly related to the incidence of RO tuberculosis were ethnicity, HIV comorbidities, treatment history, contact examinations and HIV comorbidities were the dominant factors. Insignificant variables are Age, Gender, and occupation
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