Condensation of Indole with Isatin over AlCl3/Mesoporous Aluminosilicate

Tri Esti Purbaningtias (Diploma of Analytical Chemistry, Islamic University of Indonesia, Jl. Kaliurang Km. 14.4, Besi Sleman Yogyakarta 55584)
Didik Prasetyoko (Department of Chemistry, Institut Teknologi Sepuluh Nopember, Keputih Sukolilo Surabaya 60111)
Hasliza Bahruji (Cardiff Catalysis Institute, Cardiff University, CF10 3AT Cardiff)
Yusuf Muhammad Zein (Department of Chemistry, Institut Teknologi Sepuluh Nopember, Keputih Sukolilo Surabaya 60111)
Sugeng Triwahyono (Ibnu Sina Institute for Fundamental Science Studies, Universiti Teknologi Malaysia, Skudai Johor Bahru 81310)
Arief Fadlan (Department of Chemistry, Institut Teknologi Sepuluh Nopember, Keputih Sukolilo Surabaya 60111)
Imroatul Qoniah (Department of Chemistry, Institut Teknologi Sepuluh Nopember, Keputih Sukolilo Surabaya 60111)

Indonesian Journal of Chemistry
Vol 15, No 1 (2015)

Aluminium chloride immobilized on mesoporous aluminosilicate was investigated as catalysts in the condensation of isatin with indole. AlCl3/mesoporous aluminosilicate (AlCl3/AM) catalysts were prepared by impregnation of 1, 5, 10 and 15 wt% AlCl3 on the surface of mesoporous aluminosilicate. A maximum conversion of isatin was achieved using 15% AlCl3/AM catalyst whereas the highest selectivity of 68.97% towards trisindoline was obtained using pure AM. The activity of the catalysts was depended on their acid site number and surface area. The number of Brønsted acid and the surface area affected to the conversion of isatin while the total acidity and the number of Lewis acid influenced the selectivity.