Effect of Probiotic Milk containing L. casei Shirota on Immunoglobulin G Levels among Anemic Adolescent Girls

Elya Sugianti
Annis Catur Adi (Faculty of Public Health, Airlangga University)
Ikeu Ekayanti (Faculty of Public Health, Airlangga University)
Trias Mahmudiono (Faculty of Public Health, Airlangga University)
Widati Fatmaningrum (Departement of Public Health-Preventive Medicine, Faculty of Medicine, Airlangga University)
Siti Nur Husnul Yusmiati (Faculty of Health Sains, Ma’arif Hasyim Latif University)

Health Notions
Vol 2, No 2 (2018): February

Probiotic play important role on immune systems. This study was to investigate effect of probiotic milk containing L. casei Shirota on immunoglobulin G levels among anemic adolescent girls. A total of 22 adolescent girls aged 13-18 years with anemia were included on this study. The subjects were separated into 2 groups i.e. a probiotic group and a control group by simple random sampling. During 4 weeks, a probiotic group received 1 tablet of 60 Fe elemental + 250 µg folate acid once a week and probiotic milk once daily. While a control group received 1 tablet of 60 Fe elemental + 250 µg folate acid once a week. Blood samples were collected at 0 and 4 weeks and assayed for immunoglobulin G levels by ELISA. Immunoglobulin G levels were not significantly increase after intervention. Compared with control group, probiotic milk administration in probiotic group did not significantly increased immunoglobulin G levels (p>0.05). The probiotic milk containing L. casei Shirota did not improve immunoglobulin G levels on anemic adolescent girls. Keywords: Probiotic, Immunoglobulin G levels, Anemia, Adolescent girls